| WBGene00003670 | Evidence | Paper_evidence | WBPaper00003754 |
|---|
| SMap | S_parent | Sequence | H10E21 |
| Identity | Version | 1 |
| | Name (5) |
| | DB_info | Database (10) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | nhr |
| | Allele (234) |
| | Strain | WBStrain00008405 |
| | | WBStrain00034506 |
| | | WBStrain00034508 |
| | | WBStrain00034509 |
| | | WBStrain00004023 |
| | | WBStrain00030244 |
| | RNASeq_FPKM (74) |
| | GO_annotation (17) |
| | Ortholog (30) |
| | Paralog (225) |
| | Structured_description | Concise_description | nhr-80 encodes a nuclear hormone receptor, expressed in the intestine,that regulates expression of the delta-9 desaturases FAT-5/-6/-7, andthus regulates fatty acid metabolism; NHR-80 is fully required for anyexpression of FAT-7, full expression of FAT-5/-6, viability in theabsence of FAT-6, and transcriptional hyperactivation of fat-7 in theabsence of FAT-6, and for a fully normal adult lifespan; nhr-80 isexpressed robustly in the intestine during larval and adult stages ofdevelopment, with some expression also seen in head muscles; nhr-80 isspecific to nematodes, being a divergent ortholog of HNF4 with manyparalogs in C. elegans; nhr-80(tm1011) mutants, like nhr-49 mutants,have an increased ration of saturated 18:0 fatty acids tomonounsaturated 18:1 ones (4.6 instead of 2.2); nhr-80(tm1011) mutantsare viable and fertile and have no increase in fat storage, but doublefat-6(tm331);nhr-80(tm1011) mutants, (or fat-6(tm331) mutants subjectedto nhr-80(RNAi), are synthetically lethal unless cultured on mediasupplemented with desaturated fatty acids. | Paper_evidence | WBPaper00003754 |
| | | | | | WBPaper00027749 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 12 Mar 2007 00:00:00 |
| | | Automated_description | Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in determination of adult lifespan; positive regulation of metabolic process; and post-embryonic development. Located in nucleus. Expressed in head; intestine; muscle cell; somatic nervous system; and tail neurons. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | H10E21.3a |
| | | H10E21.3b |
| | Corresponding_transcript | H10E21.3a.1 |
| | | H10E21.3b.1 |
| | Other_sequence (23) |
| | Associated_feature | WBsf650778 |
| | | WBsf226071 |
| | Transcription_factor | WBTranscriptionFactor000724 |
| Experimental_info | RNAi_result (24) |
| | Expr_pattern | Expr1184 |
| | | Expr9203 |
| | | Expr1028389 |
| | | Expr1153088 |
| | | Expr2014232 |
| | | Expr2032473 |
| | Drives_construct | WBCnstr00008319 |
| | | WBCnstr00010136 |
| | | WBCnstr00013793 |
| | | WBCnstr00018585 |
| | | WBCnstr00035958 |
| | Construct_product | WBCnstr00008319 |
| | | WBCnstr00010136 |
| | | WBCnstr00013793 |
| | | WBCnstr00016839 |
| | | WBCnstr00018585 |
| | | WBCnstr00035958 |
| | Regulate_expr_cluster | WBPaper00040998:nhr-80_regulated |
| | Microarray_results (24) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032425:down_in_zfp-1 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_larva_enriched |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00042561:smg-2(RNAi)_upregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00046338:intestine_unique |
| | | WBPaper00047132:glp-1(ts)-25C_upregulated |
| | | WBPaper00048926:miaserin_upregulated_adult-day5 |
| | | WBPaper00049732:blmp-1(tm548)_vs_N2_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059191:hsp-16.2p-LIN-29_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059987:Wounding_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_mRNA |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Intestine |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:gtl-1-hum-8_16432 |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:2_0 |
| | | WBPaper00065841:57_0 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4386_cluster_3_3 |
| | | cgc4489_group_16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00027342:alpha-Synuclein(A53T)_downregulated |
| | | WBPaper00027342:alpha-Synuclein(WT)_downregulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00034757:up_by_oxidative_stress |
| | | WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | [cgc6390]:Cluster_C |
| | Interaction (27) |
| | WBProcess | WBbiopr:00000121 |
| Map_info | Map | III | Position | -27.2207 | Error | 0.030731 |
| | Positive | Positive_clone | H10E12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | H10E21 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (37) |
| Picture | WBPicture0000013097 |
| | WBPicture0000013098 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
