| WBGene00003523 | Evidence | Author_evidence | Moehrlen F |
|---|
| SMap | S_parent | Sequence | C05D11 |
| Identity | Version | 1 |
| | Name | CGC_name | nas-4 | Person_evidence | WBPerson1103 |
| | | Sequence_name | C05D11.6 |
| | | Molecular_name | C05D11.6a |
| | | | C05D11.6a.1 |
| | | | CE37080 |
| | | | C05D11.6b |
| | | | CE44904 |
| | | | C05D11.6c |
| | | | CE44965 |
| | | | C05D11.6a.2 |
| | | | C05D11.6b.1 |
| | | | C05D11.6c.1 |
| | | Other_name | CELE_C05D11.6 | Accession_evidence | NDB | BX284603 |
| | | Public_name | nas-4 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | nas |
| | Allele (55) |
| | Strain | WBStrain00035277 |
| | RNASeq_FPKM (74) |
| | GO_annotation (15) |
| | Ortholog (28) |
| | Paralog (48) |
| | Structured_description | Concise_description | nas-4 encodes a predicted extracellular matrix metalloprotease of the M12A (astacin) family that contains an N-terminal signal sequence and a catalytic domain, but no recognizable regulatory domains in the C-terminus; as loss of nas-4 activity via RNAi results in no obvious abnormalities, the precise role of NAS-4 in C. elegans development and/or behavior is not yet known; however, an NAS-4 translational reporter is expressed in the pharynx and intestine in larvae and adults, suggesting a role for NAS-4 in digestion; NAS-4 is specifically detected within cells of the pharyngeal procorpus, metacorpus, isthmus, and terminal bulb, with extracellular expression detected in the lumen of the terminal bulb and in the gut. | Paper_evidence | WBPaper00004403 |
| | | | | | WBPaper00005654 |
| | | | | | WBPaper00006254 |
| | | | | | WBPaper00024497 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 15 Nov 2004 00:00:00 |
| | | Automated_description | Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Expressed in intestine; marginal cell; and pharynx. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C05D11.6a |
| | | C05D11.6b |
| | | C05D11.6c |
| | Corresponding_CDS_history | C05D11.6:wp112 |
| | | C05D11.6:wp127 |
| | Corresponding_transcript | C05D11.6a.1 |
| | | C05D11.6a.2 |
| | | C05D11.6b.1 |
| | | C05D11.6c.1 |
| | Other_sequence | FC547268.1 |
| | | JO469184.1 |
| | | ACC23389_1 |
| | | JI181768.1 |
| | | CJC16588_1 |
| | | Dviv_isotig26663 |
| | Associated_feature | WBsf992756 |
| | | WBsf226811 |
| | | WBsf226812 |
| Experimental_info | RNAi_result (7) |
| | Expr_pattern | Chronogram170 |
| | | Expr2803 |
| | | Expr7412 |
| | | Expr8907 |
| | | Expr1025181 |
| | | Expr1143830 |
| | | Expr2013887 |
| | | Expr2032127 |
| | Drives_construct | WBCnstr00001207 |
| | | WBCnstr00010956 |
| | | WBCnstr00012555 |
| | | WBCnstr00013601 |
| | | WBCnstr00036072 |
| | Construct_product | WBCnstr00010956 |
| | | WBCnstr00013601 |
| | | WBCnstr00036072 |
| | Microarray_results (26) |
| | Expression_cluster | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1678 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00038168:lin-15B(n744)_downregulated |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq |
| | | WBPaper00044037:eat-2_upregulated |
| | | WBPaper00044260:1-methylnicotinamide_upregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00045390:ubc-9(RNAi)_upregulated |
| | | WBPaper00045918:96h_infection_recovery_upregulated |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00046024:sleep_upregulated_oscillating |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049018:swsn-2.2(RNAi)_upregulated |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050801:DAF-12_dauer_regulome |
| | | WBPaper00050801:DAF-16_dauer_regulome |
| | | WBPaper00050801:DPY-21_dauer_regulome |
| | | WBPaper00051388:Glucose-diet_upregulated |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051404:alg-2(ok304)_downregulated |
| | | WBPaper00053020:sid-3(ok973)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00054410:set-9(rw5)_downregulated |
| | | WBPaper00054410:set-26(tm2467)_downregulated |
| | | WBPaper00055013:hmg-3(bar24)_downregulated |
| | | WBPaper00055013:spt-16(RNAi)_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055386:daf-2(e1370)_upregulated |
| | | WBPaper00055386:eat-2(ad465)_upregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055969:electromagnetic-field_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056167:ifo-1(kc2)_downregulated |
| | | WBPaper00056169:rrf-3(pk1426)_downregulated_L4 |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_L1 |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056330:glycine_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056586:kri-1(ok1251)_upregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium |
| | | WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated |
| | | WBPaper00057140:pptr-1(tm3103)_downregulated |
| | | WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00058948:npr-8(ok1439)_downregulated_PA14 |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059117:B.subtilis_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059728:5ug_cholesterol_upregulated |
| | | WBPaper00059728:20ug_cholesterol_upregulated |
| | | WBPaper00059739:hira-1(gk835598)_downregulated_L1 |
| | | WBPaper00060084:cco-1(RNAi)_downregulated_N2 |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060273:vrk-1(RNAi)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:hypoxia_downregulated |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(et18)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061340:ILso |
| | | WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3 |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb120_upregulated |
| | | WBPaper00061527:col-128-cdh-10_9234 |
| | | WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_downregulated |
| | | WBPaper00061653:alh-4(hj221)_downregulated |
| | | WBPaper00061753:csr-1(tor159)_upregulated_20C |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:daf-16(RNAi)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13) |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062456:doxycycline_upregulated_N2_transcript |
| | | WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064532:pals-25(icb98)_downregulated |
| | | WBPaper00064933:bcf-1(ylf1)_upregulated_transcript |
| | | WBPaper00064992:heat-shock_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065258:anchor-cell_depleted |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065746:eat-2(ad1113)_downregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:11_2 |
| | | WBPaper00065841:13_1 |
| | | WBPaper00065841:21_1 |
| | | WBPaper00065841:44_1 |
| | | WBPaper00066110:Doxorubicin_upregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066232:ash-2(RNAi)_downregulated_WT |
| | | cgc4489_group_8 |
| | | cgc4489_group_13 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026952:class_E |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00032948:FedUp |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00034739:RIL17lessRIL14 |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00038172:aak-2overexpression_down_regulated |
| | | WBPaper00038172:crh-1null_down_regulated |
| | | WBPaper00038172:tax-6null_down_regulated |
| | | WBPaper00040185:nhr-23(RNAi)_downregulated |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00044091:Bpseudomallei_repressed_12h |
| | | WBPaper00045015:nhr-25(RNAi)_upregulated |
| | | WBPaper00046548:dafachronic-acid_upregulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | [cgc6390]:Cluster_B |
| | | [cgc6390]:mixed_spermatogenesis-somatic |
| | Interaction (44) |
| Map_info | Map | III | Position | -1.28376 | Error | 0.000983 |
| | Positive | Positive_clone | C05D11 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00006254 |
| | WBPaper00025850 |
| | WBPaper00038491 |
| | WBPaper00055090 |
| | WBPaper00058138 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
