WormBase Tree Display for Gene: WBGene00003435

WBGene00003435 SMap: S_parent: Sequence: C33F10
  Identity: Version: 1
    Name: CGC_name: msp-40 Person_evidence: WBPerson680
      Sequence_name: C33F10.9
      Molecular_name: C33F10.9
        C33F10.9.1
        CE02806
      Other_name: CELE_C33F10.9 Accession_evidence: NDB BX284602
      Public_name: msp-40
    DB_info: Database: AceView gene 2F115
        WormQTL gene WBGene00003435
        WormFlux gene WBGene00003435
        NDB locus_tag CELE_C33F10.9
        NCBI gene 173830
        RefSeq protein NM_062464.8
        SwissProt UniProtAcc P53017
        UniProt_GCRP UniProtAcc P53017
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: msp
    Allele (11)
    Legacy_information: [C.elegansII] NMK. Encodes MSP (16kD); msp-3 cluster. [Ward et al. (1988); BA]
    Strain: WBStrain00051002
    RNASeq_FPKM (74)
    Ortholog (13)
    Paralog (52)
    Structured_description: Concise_description: msp-40 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Paper_evidence: WBPaper00001023
            WBPaper00002143
            WBPaper00004591
            WBPaper00005670
          Curator_confirmed: WBPerson324
          Date_last_updated: 31 Mar 2005 00:00:00
      Automated_description: Expressed in gonad; oocyte; and sperm. Is predicted to encode a protein with the following domains: Major sperm protein (MSP) domain; MSP (Major sperm protein) domain; PapD-like superfamily; and Immunoglobulin-like fold. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info (4)
  Experimental_info: RNAi_result (17)
    Expr_pattern: Expr3417
      Expr1010325
      Expr1145800
      Expr2013776
      Expr2032015
    Drives_construct: WBCnstr00036118
    Construct_product: WBCnstr00036118
    Antibody: WBAntibody00000037
      WBAntibody00000038
      WBAntibody00000854
      WBAntibody00000855
      WBAntibody00000856
      WBAntibody00000857
      WBAntibody00000858
    Microarray_results (14)
    Expression_cluster: WBPaper00029047:atx-3_upregulated
      WBPaper00038118:aak-2(gt33)_downregulated
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038289:oocyte_protein
      WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00041071:spe-44_downregulated
      WBPaper00041954:ethanol_upregulated
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042477:prp-8(RNAi)_downregulated_RNAseq
      WBPaper00043945:MeHg_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044616:alg-3-4_downregulated_gene
      WBPaper00044736:rising_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00045316:prg-1_upregulated_L1
      WBPaper00045521:Spermatogenic
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045729:gld-2(RNAi)_upregulated
      WBPaper00045809:rsd-2(yp10)_downregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00046805:csr-1(RNAi)_upregulated_Set2
      WBPaper00046805:P-granule-RNAi_upregulated_Set1
      WBPaper00046805:P-granule-RNAi_upregulated_Set2
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00047132:glp-1(ts)-25C_upregulated_skn-1-dependent
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049489:AMsh-glia_enriched
      WBPaper00049498:npr-1(ur89)_regulated_2
      WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049954:BPA_downregulated
      WBPaper00049954:BPS_downregulated
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050231:male_enriched
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051265:F1_hrde-1(tm1200)_upregulated
      WBPaper00051265:F1_morc-1(tm6048)_upregulated
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053664:ins-11(tm1053)_upregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00054410:set-9(rw5)_downregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055648:sperm_expressed
      WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00055981:fog-2(q71)_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056039:ptl-1(ok621)_downregulated
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:flcn-1(ok975)_downregulated
      WBPaper00056586:kri-1(ok1251)_upregulated
      WBPaper00056731:human-amylin_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00057347:nhr-14(tm1473)_upreglated
      WBPaper00058598:spn-4(tm291)_downregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_PA14
      WBPaper00058948:PA14_upregulated
      WBPaper00059175:hlh-17p-XBP-1_upregulated
      WBPaper00059253:stearic-acid_downregulated
      WBPaper00059253:sucrose_downregulated
      WBPaper00059334:sacy-1(depletion)_regulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059426:Ag-nanoparticles_upregulated
      WBPaper00059426:SiO2-nanoparticles_upregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060526:plp-1(ok2155)_upregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060744:Radiation_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00060911:prx-5(RNAi)_downregulated_mRNA
      WBPaper00060921:cat-2(e1112)_downregulated
      WBPaper00060921:tbh-1(ok1196)_downregulated
      WBPaper00061040:eat-2(ad1116)_downregulated
      WBPaper00061045:Y56A3A.22(cck200)_upregulated
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061478:pie-1(ne4433)_upregulated
      WBPaper00061479:hda-1(ne4747)_upregulated
      WBPaper00061479:hda-1(ne4748)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:msp-63-msp-33
      WBPaper00061572:oleic-acid-specific_mating_upregulated
      WBPaper00061651:Sperm_enriched
      WBPaper00061853:osm-3(dh441)_downregulated
      WBPaper00061853:osm-3(dh441)_downregulated_tunicamycin
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064473:ets-4(rrr16)_upregulated
      WBPaper00064502:nhr-23(kry61);spe-44(fx110)_downregulated
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064721:fasn-1(g14)_upregulated_starved
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064788:ketamine_downregulated
      WBPaper00064999:miR-229-64-65-66_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C
      WBPaper00065158:AFD_depleted
      WBPaper00065578:gcn-1(nc40)_upregulated
      WBPaper00065623:24
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065841:3_3
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00066038:mip-1(how5)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      cgc4386_cluster_1_1
      cgc4489_group_11
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026629:L3_male_enriched
      WBPaper00031184:acrylamide_upregulated
      WBPaper00034661:AgNPs_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00036375:depleted_in_PVD_OLL
      WBPaper00040876:mir-35_upregulated
      WBPaper00040963:Q50_up
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00040963:TA100_up
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041002:HQ_3d_0.2mM_Up
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045374:Benzene_upregulated
      WBPaper00045673:colistin_downregulated
      WBPaper00046639:tyrosol_upregulated
      WBPaper00051387:Triclosan_downregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_D
      [cgc6390]:spermatogenesis-enriched
    Interaction (226)
  Map_info: Map: II Position: -3.01029 Error: 0.003527
    Positive: Positive_clone: C33F10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00001023
    WBPaper00015440
    WBPaper00024312
    WBPaper00025088
    WBPaper00041549
    WBPaper00057218
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene