WormBase Tree Display for Gene: WBGene00002248

WBGene00002248 Evidence: Paper_evidence: WBPaper00006014
  SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: lam-3 Person_evidence: WBPerson1052
      Sequence_name: T22A3.8
      Molecular_name: T22A3.8
        T22A3.8.1
        CE31067
      Other_name: lama1/2 Accession_evidence: EMBL AF074902
        CELE_T22A3.8 Accession_evidence: NDB BX284601
      Public_name: lam-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lam
    Allele (147)
    Possibly_affected_by: WBVar02154115
      WBVar02154116
    Strain: WBStrain00027269
      WBStrain00037801
      WBStrain00050776
    RNASeq_FPKM (74)
    GO_annotation: 00011601
      00011602
      00011603
      00011604
      00011605
      00011606
      00011607
      00011608
      00011609
    Ortholog (46)
    Paralog: WBGene00001328 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002247 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006787 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006746 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00016913 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018304 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006432 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020581 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: lam-3 encodes one of two C. elegans a laminin A subunits and is orthologous to human laminin alpha2; LAM-3 is a basement membrane component required for normal tissue development, including pharyngeal development; lam-3 is expressed in the pharynx and hypodermis, and also weakly in the intestine. Paper_evidence: WBPaper00006014
            WBPaper00040339
            WBPaper00037071
          Curator_confirmed (3)
          Date_last_updated: 26 Jan 2012 00:00:00
      Automated_description: Predicted to be involved in animal organ morphogenesis and tissue development. Located in basement membrane. Expressed in several structures, including excretory canal; pharyngeal-intestinal valve; pharynx; somatic nervous system; and spermatheca. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; and myopia. Is an ortholog of human LAMA1 (laminin subunit alpha 1) and LAMA2 (laminin subunit alpha 2). Paper_evidence: WBPaper00065943
          Curator_confirmed (2)
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9884 Homo sapiens Paper_evidence: WBPaper00006014
          Curator_confirmed: WBPerson324
          Date_last_updated: 08 Nov 2023 00:00:00
    Potential_model: DOID:0110636 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6482)
      DOID:11830 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6482)
      DOID:9884 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6482)
      DOID:0110274 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6482)
    Disease_relevance: lam-3 encodes a laminin A subunit orthologous to human laminin alpha2 (LAMA2), which when mutated leads to merosin-deficient congenital muscular dystrophy. Homo sapiens Paper_evidence: WBPaper00006014
          Accession_evidence: OMIM 156225
          Curator_confirmed: WBPerson324
          Date_last_updated: 16 Nov 2011 00:00:00
  Models_disease_in_annotation: WBDOannot00000023
  Molecular_info: Corresponding_CDS: T22A3.8
    Corresponding_CDS_history: T22A3.8:wp80
    Corresponding_transcript: T22A3.8.1
    Other_sequence (22)
    Associated_feature: WBsf656886
      WBsf656887
      WBsf656888
      WBsf656889
      WBsf656890
      WBsf985046
      WBsf985047
      WBsf218465
      WBsf218466
  Experimental_info: RNAi_result (24)
    Expr_pattern: Expr2621
      Expr2624
      Expr10827
      Expr1028119
      Expr1031322
      Expr1157327
      Expr2013009
      Expr2031241
    Drives_construct: WBCnstr00010875
      WBCnstr00036362
    Construct_product: WBCnstr00036362
    Antibody: WBAntibody00000660
      WBAntibody00000661
    Microarray_results (27)
    Expression_cluster: WBPaper00024505:pharyngeal_enriched
      WBPaper00030922:glycosylated_protein
      WBPaper00035197:fer-1_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched
      WBPaper00048690:hermaphrodite-Z1-Z4_enriched
      WBPaper00048690:male-Z1-Z4-daughter_enriched
      WBPaper00048690:male-Z1-Z4_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049018:ham-3(RNAi)_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_4
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049954:BPS_upregulated
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_enriched
      WBPaper00050990:body-muscle_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051305:vit-2(ac3)_upregulated
      WBPaper00051388:Glucose-diet_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056617:adr-1_upregulated_L4_transcript
      WBPaper00056826:SGP_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
      WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00059117:B.subtilis_downregulated
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_downregulated_L1
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-extract_12h_regulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:hypergravity_10xg_upregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:g2_parent
      WBPaper00061340:GLR
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:I1_parent
      WBPaper00061340:I2_grandparent
      WBPaper00061340:M1_parent
      WBPaper00061340:M4_parent
      WBPaper00061340:mc1
      WBPaper00061340:mc2
      WBPaper00061340:mc3
      WBPaper00061340:Neuroblast_AVG_RIR
      WBPaper00061340:Neuroblast_I6_M5
      WBPaper00061340:Neuroblast_M2_M3
      WBPaper00061340:Parent_of_g1P_I3
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061340:Pharyngeal_marginal_cell
      WBPaper00061340:Pharyngeal_neuron
      WBPaper00061340:pm3_pm4_pm5
      WBPaper00061340:pm7
      WBPaper00061340:P_cell
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061479:hrde-1(tm1200)_upregulated
      WBPaper00061527:uggt-1_21889-tag-320_20312
      WBPaper00061753:csr-1(tor159)_upregulated_20C
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062456:doxycycline_upregulated_N2_protein
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064735:bet-1(uth41)_vs_N2_upregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065074:glna(-)_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065841:9_0
      WBPaper00065841:9_2
      WBPaper00065841:24_0
      WBPaper00065841:26_0
      WBPaper00065841:26_1
      WBPaper00065841:31_0
      WBPaper00065841:78_0
      WBPaper00065995:M.humicola-extract_downregulated_old-1(ok1273)
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066093:E.coli-purE_downregulated
      cgc4386_cluster_6_4
      cgc4489_group_2
      cgc4489_group_21
      WBPaper00025032:cluster_37
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00036286:Pattern_F
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040963:Q50_down
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040963:TA300_down
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00046548:dafachronic-acid_upregulated
      WBPaper00046639:tyrosol_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_5
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(53_min)
    Interaction (53)
  Map_info: Map: I Position: 5.05872 Error: 0.000103
    Positive: Positive_clone: T22A3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (18)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene