WormBase Tree Display for Gene: WBGene00002227

WBGene00002227 SMap: S_parent: Sequence: W02B12
  Identity: Version: 2
    Name: CGC_name: klp-17 Person_evidence: WBPerson589
      Sequence_name: W02B12.7
      Molecular_name: W02B12.7
        W02B12.7.1
        CE37934
      Other_name: CELE_W02B12.7 Accession_evidence: NDB BX284602
      Public_name: klp-17
    DB_info: Database: AceView gene 2L756
        WormQTL gene WBGene00002227
        WormFlux gene WBGene00002227
        NDB locus_tag CELE_W02B12.7
        Panther gene CAEEL|WormBase=WBGene00002227|UniProtKB=Q23124
          family PTHR47972
        NCBI gene 174750
        RefSeq protein NM_064045.6
        TREEFAM TREEFAM_ID TF320932
        TrEMBL UniProtAcc Q23124
        UniProt_GCRP UniProtAcc Q23124
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 14 Dec 2004 16:41:25 WBPerson1846 Event: Split_into: WBGene00044026
      Split_into: WBGene00044026
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: klp
    Allele (33)
    Possibly_affected_by: WBVar02153214
    Strain (2)
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (24)
    Paralog (19)
    Structured_description: Concise_description: klp-17 encodes a C-terminal kinesin motor protein orthologous to Drosophila NCD and Saccharomyces cerevisiae KAR3; by homology, KLP-17 is predicted to function as a minus-end directed motor; loss of klp-17 activity via RNAi results in embryonic lethality generally at the one- or two-cell stage with disorganized mitotic spindles and polyploid nuclei, suggesting that KLP-17 plays a role in chromosome segregation and germline development; in situ hybridization studies reveal that klp-17 mRNA is localized specifically to cell nuclei during early development, from the one-cell stage of embryogenesis until early larval stages; a klp-17::gfp transgene did not yield detectable GFP expression, but did result in a small percentage of morphologically abnormal males and intersexual animals that grew slowly and died upon reaching maturity, consistent with a role for klp-17 in chromosome dynamics. Paper_evidence: WBPaper00003893
            WBPaper00003965
          Curator_confirmed: WBPerson1843
          Date_last_updated: 14 Nov 2005 00:00:00
      Automated_description: Predicted to enable microtubule binding activity. Involved in chromosome segregation. Predicted to be located in microtubule cytoskeleton. Expressed in germ line and sperm. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: W02B12.7
    Corresponding_CDS_history: W02B12.7:wp137
    Corresponding_transcript: W02B12.7.1
    Other_sequence: Tcir_isotig17190
      XI03693
      FD517427.1
      Tcir_isotig27917
      CSC02222_1
    Associated_feature: WBsf223939
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr982
      Expr1101
      Expr15130
      Expr1023203
      Expr1158108
      Expr2012960
      Expr2031192
    Drives_construct: WBCnstr00036372
    Construct_product: WBCnstr00036372
    Microarray_results (20)
    Expression_cluster: WBPaper00005700:transmembrane_protein
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044736:rising_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00044786:emr-1(gk119)_upregulated
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045521:Spermatogenic
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00046805:P-granule-RNAi_upregulated_Set1
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00050231:male_enriched
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053657:JU2519_M.humicola-infection_24hr
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00055013:hmg-3(bar24)_downregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:sperm_expressed
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_adult
      WBPaper00056169:rrf-3(pk1426)_upregulated_L4
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:flcn-1(ok975)_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061527:C34B2.3_17388-T01C3.5
      WBPaper00061753:csr-1(tor159)_downregulated_25C
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00066038:mip-1(how5)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066093:E.coli-purE_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066118:cyclobutrifluram_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4489_group_18
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036286:Pattern_E
      WBPaper00038172:aak-2overexpression_up_regulated
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040963:Q200_up
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045263:ProLongevity-mtROS_downregulated
      WBPaper00045673:colistin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_D
      [cgc6390]:Cluster_E
      [cgc6390]:spermatogenesis-enriched
    Interaction (43)
  Map_info: Map: II Position: 3.49314 Error: 0.002649
    Positive: Positive_clone: W02B12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4466
    Pseudo_map_position
  Reference: WBPaper00003893
    WBPaper00003965
    WBPaper00005076
    WBPaper00015680
    WBPaper00015683
    WBPaper00022947
    WBPaper00025098
    WBPaper00038491
    WBPaper00055090
    WBPaper00064797
  Remark: Sequence connection from [Siddiqui SS], [krb 020711]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene