| WBGene00002101 | Evidence | Paper_evidence | WBPaper00003189 |
|---|
| | | WBPaper00004209 |
| | | WBPaper00004623 |
| SMap | S_parent | Sequence | T28B8 |
| Identity | Version | 1 |
| | Name | CGC_name | ins-18 | Person_evidence | WBPerson339 |
| | | Sequence_name | T28B8.2 |
| | | Molecular_name | T28B8.2 |
| | | | T28B8.2.1 |
| | | | CE27217 |
| | | Other_name | ins-1 | Accession_evidence | EMBL | AB008096 |
| | | | Ceinsulin-1 |
| | | | igf-1 |
| | | | CELE_T28B8.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | ins-18 |
| | DB_info | Database | AceView | gene | 1I725 |
| | | | WormQTL | gene | WBGene00002101 |
| | | | SignaLink | protein | WBGene00002101 |
| | | | WormFlux | gene | WBGene00002101 |
| | | | NDB | locus_tag | CELE_T28B8.2 |
| | | | NCBI | gene | 172600 |
| | | | RefSeq | protein | NM_001392642.1 |
| | | | TREEFAM | TREEFAM_ID | TF320519 |
| | | | TrEMBL | UniProtAcc | G5ECC6 |
| | | | UniProt_GCRP | UniProtAcc | G5ECC6 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ins |
| | Allele (30) |
| | Legacy_information | [Ferguson K] ins for INSulin related. No mutants known. |
| | Strain | WBStrain00036424 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00011503 |
| | | 00011504 |
| | | 00011505 |
| | | 00011506 |
| | | 00011507 |
| | Ortholog (24) |
| | Paralog | WBGene00002100 | Caenorhabditis elegans | From_analysis | TreeFam |
| | Structured_description | Concise_description | ins-18 encodes one of 40 C. elegans insulin/IGF-like peptides; INS-18, along with INS-1, are the only two C. elegans insulins that contain a C peptide, characteristic of mammalian insulins, connecting the B and A chains; overexpression of ins-18 induces dauer arrest at 26 degrees C and enhances the dauer arrest seen in a daf-2 mutant at 20 degrees C, suggesting that INS-18 functions to antagonize DAF-2 receptor signaling; in addition, daf-7; ins-18 doubly mutant animals show dauer maintenance defects, suggesting that INS-18 activity is required to properly maintain the dauer developmental state; ins-18::gfp reporters are expressed in neurons and the intestine. | Paper_evidence | WBPaper00004209 |
| | | | | | WBPaper00004623 |
| | | | | | WBPaper00029214 |
| | | | | | WBPaper00031997 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 15 Aug 2008 00:00:00 |
| | | Automated_description | Involved in maintenance of dauer; negative regulation of insulin receptor signaling pathway; and regulation of dauer entry. Expressed in several structures, including coelomocyte; gonad; head muscle; nerve ring; and neurons. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | T28B8.2 |
| | Corresponding_CDS_history | T28B8.2:wp47 |
| | Corresponding_transcript | T28B8.2.1 |
| | Other_sequence (13) |
| | Associated_feature | WBsf643515 |
| | | WBsf984356 |
| | | WBsf984357 |
| | | WBsf1010193 |
| | | WBsf218127 |
| Experimental_info | RNAi_result | WBRNAi00028245 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00063197 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00092917 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00063196 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00069854 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00004334 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00107963 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00054383 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00063818 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (12) |
| | Drives_construct | WBCnstr00013488 |
| | | WBCnstr00015093 |
| | | WBCnstr00017682 |
| | | WBCnstr00017800 |
| | | WBCnstr00021719 |
| | | WBCnstr00036453 |
| | Construct_product | WBCnstr00015093 |
| | | WBCnstr00019165 |
| | | WBCnstr00019275 |
| | | WBCnstr00036453 |
| | Antibody | WBAntibody00000292 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:glr-1(+)-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045934:wrn-1(gk99)_downregulated |
| | | WBPaper00046805:P-granule-RNAi_upregulated_Set1 |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031) |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00055648:nerve-ring_expressed |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059117:B.subtilis_upregulated |
| | | WBPaper00059421:daf-1(m40)_upregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060445:nfki-1(cer1)_downregulated_L4 |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:ADF |
| | | WBPaper00061340:AIA |
| | | WBPaper00061340:AWA |
| | | WBPaper00061340:GLR |
| | | WBPaper00061340:M_cell |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061527:flp-5-F17C11.2 |
| | | WBPaper00061651:ADF_enriched |
| | | WBPaper00061651:AIA_enriched |
| | | WBPaper00061651:AQR_enriched |
| | | WBPaper00061651:ASEL_enriched |
| | | WBPaper00061651:ASER_enriched |
| | | WBPaper00061651:ASJ_enriched |
| | | WBPaper00061651:AWA_enriched |
| | | WBPaper00061651:AWB_enriched |
| | | WBPaper00061651:AWC_OFF_enriched |
| | | WBPaper00061651:AWC_ON_enriched |
| | | WBPaper00061651:IL2_DV_enriched |
| | | WBPaper00061651:IL2_LR_enriched |
| | | WBPaper00061651:LUA_enriched |
| | | WBPaper00061651:M1_enriched |
| | | WBPaper00061651:M2_enriched |
| | | WBPaper00061651:PHA_enriched |
| | | WBPaper00061651:PHB_enriched |
| | | WBPaper00061651:PLM_enriched |
| | | WBPaper00061651:PQR_enriched |
| | | WBPaper00061651:PVR_enriched |
| | | WBPaper00061651:RIR_enriched |
| | | WBPaper00061651:RMH_enriched |
| | | WBPaper00061651:URB_enriched |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062520:qui-1(db104)_upregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_uninfected |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065623:89 |
| | | WBPaper00065623:133 |
| | | WBPaper00065623:157 |
| | | WBPaper00065841:20_2 |
| | | WBPaper00065841:35_1 |
| | | WBPaper00065841:35_2 |
| | | WBPaper00065841:35_4 |
| | | WBPaper00065841:39_2 |
| | | WBPaper00065841:39_3 |
| | | WBPaper00065841:47_0 |
| | | WBPaper00065841:56_0 |
| | | WBPaper00065841:94_0 |
| | | WBPaper00065841:95_0 |
| | | WBPaper00065841:104_0 |
| | | WBPaper00065841:108_0 |
| | | WBPaper00065841:137_0 |
| | | WBPaper00065841:142_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066110:Cisplatin_upregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_13 |
| | | WBPaper00005124:progesterone_10-7M_regulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00038172:tax-6null_up_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042274:tbx-2(bx59)_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | [cgc5976]:class_1 |
| | | [cgc6390]:male_soma-enriched |
| | Interaction (94) |
| Map_info | Map | I | Position | 2.60082 | Error | 0.007891 |
| | Positive | Positive_clone | T28B8 | Author_evidence | Ferguson KC |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (99) |
| Remark (2) |
| Method | Gene |
