WormBase Tree Display for Gene: WBGene00002019

WBGene00002019 SMap: S_parent: Sequence: T27E4
  Identity: Version: 1
    Name (5)
    DB_info: Database: AceView gene 5J569
        WormQTL gene WBGene00002019
        WormFlux gene WBGene00002019
        NDB locus_tag CELE_T27E4.3
        Panther gene CAEEL|WormBase=WBGene00002019|UniProtKB=P02513
          family PTHR45640
        NCBI gene 179287
        RefSeq protein NM_072954.5
        SwissProt UniProtAcc P02513
        UniProt_GCRP UniProtAcc P02513
        OMIM gene 123580
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hsp
    Allele: WBVar01499903
      WBVar01500129
      WBVar00091863
      WBVar01499419
      WBVar01499420
      WBVar01499056
      WBVar01499249
      WBVar01499316
    Strain: WBStrain00030548
      WBStrain00030720
      WBStrain00030838
      WBStrain00031504
      WBStrain00034987
    In_cluster: HSP16A
    RNASeq_FPKM (74)
    GO_annotation: 00038768
      00038769
      00038770
      00038771
      00038772
      00105672
      00105748
      00106138
      00106139
    Ortholog (91)
    Paralog (17)
    Structured_description: Concise_description: hsp-16.48 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; an hsp-16.48 reporter fusion, expressed broadly but most strongly in body muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.48 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. Paper_evidence: WBPaper00001187
            WBPaper00001497
            WBPaper00004424
            WBPaper00013029
            WBPaper00013239
            WBPaper00013280
          Curator_confirmed: WBPerson1843
          Date_last_updated: 05 Nov 2004 00:00:00
      Automated_description: Predicted to enable unfolded protein binding activity. Involved in determination of adult lifespan and response to heat. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including coelomocyte; enteric muscle; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Is an ortholog of human CRYAA (crystallin alpha A). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110266 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2388)
  Molecular_info: Corresponding_CDS: T27E4.3
    Corresponding_transcript: T27E4.3.1
    Other_sequence (31)
    Associated_feature: WBsf977960
      WBsf977961
      WBsf977963
      WBsf232205
  Experimental_info: RNAi_result: WBRNAi00093732 Inferred_automatically: RNAi_primary
      WBRNAi00063167 Inferred_automatically: RNAi_primary
      WBRNAi00106385 Inferred_automatically: RNAi_primary
      WBRNAi00106384 Inferred_automatically: RNAi_primary
      WBRNAi00027602 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1381
      Expr15006
      Expr15519
      Expr1028019
      Expr1157857
      Expr1200271
      Expr2012620
      Expr2030856
    Drives_construct (24)
    Construct_product (6)
    Antibody: WBAntibody00001859
    Microarray_results (21)
    Expression_cluster: WBPaper00034755:ALG-1_interacting
      WBPaper00036231:long-telomeres_upregulated
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037624:ets-4(ok165)_downregulated
      WBPaper00038118:stress_upregulated_N2
      WBPaper00038289:oocyte_protein
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040135:heat-shock_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040285:H2S_12hr_upregulated
      WBPaper00040731:Static_Magnetic_Field_upregulated
      WBPaper00042034:NO_upregulated_N2
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044316:CH3HgCl_2.0uM_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044316:HgCl2_20uM_upregulated
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045390:tunicamycin_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_downregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046795:starvation_upregulated
      WBPaper00048644:germline_enriched
      WBPaper00048785:heat-shock_upregulated
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_downregulated
      WBPaper00049098:heat-induced_hrde-1(tm1200)
      WBPaper00049098:heat-induced_N2
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049498:npr-1(ur89)_regulated_4
      WBPaper00049635:dop-1(vs100)_upregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050636:aging_regulated_insoluble_protein
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053092:procyanidins_upregulated
      WBPaper00053254:hsp-90(RNAi)_upregulated_protein
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053402:his-3(RNAi)_upregulated
      WBPaper00053664:ins-11(tm1053)_upregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055060:flr-1(RNAi)_downregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:male-vas-deferens_expressed
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055897:heat-shock_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:flcn-1(ok975)_upregulated
      WBPaper00056617:adr-1(tm668)_downregulated_L4_protein
      WBPaper00056731:human-amylin_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated
      WBPaper00057196:raga-1(ok386)_downregulated)
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00058725:sftb-1(cer39)_upregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00058969:RIS_enriched
      WBPaper00059334:sacy-1(depletion)_regulated
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059490:dcr-1(m9375)_downregulated
      WBPaper00059598:HeatShock_upregulated
      WBPaper00059605:simr-1(cmp36)_downregulated
      WBPaper00059735:glucose_downregulated_N2
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059739:hira-1(gk835598)_upregulated_L4
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060764:swsn-9(ok1354)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ADF
      WBPaper00061340:ADF_AWB
      WBPaper00061340:ASG_AWA
      WBPaper00061340:ASI_parent
      WBPaper00061340:AUA
      WBPaper00061340:AVE
      WBPaper00061340:AWC
      WBPaper00061340:BAG
      WBPaper00061340:CEP
      WBPaper00061340:IL1
      WBPaper00061340:MC
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:Neuroblast_URX_CEPDx
      WBPaper00061340:OLQ
      WBPaper00061340:Rectal_cell
      WBPaper00061340:RIC
      WBPaper00061340:URX
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061466:nath-10(icb102)_upregulated
      WBPaper00061478:pie-1(ne4433)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061527:hsp-16.2-F44E5.4_19238
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061590:CGP37157_upregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062193:daf-16(RNAi)_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062237:dnj-21(RNAi)_upregulated_protein
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062345:bortezomib_30min_upregulated_N2
      WBPaper00062345:bortezomib_30min_upregulated_zip-1(jy13)
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_protein
      WBPaper00064005:starvation_downregulated_N2_protein
      WBPaper00064080:miR-58_miRNA_interacting
      WBPaper00064122:vulva_transcriptome
      WBPaper00064130:Beta-Amyloid_8h_upregulated_mRNA
      WBPaper00064130:Beta-Amyloid_upregulated_protein
      WBPaper00064201:SNA-3_interacting
      WBPaper00064225:heat-shock_upregulated_protein
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mes-4(bn73)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064502:spe-44(fx110)_downregulated
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064789:Day3_vs_Day1_downregulated_neuron
      WBPaper00064789:Day6_vs_Day1_downregulated_neuron
      WBPaper00064789:Day9_vs_Day1_downregulated_neuron
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00064952:Day1_vs_L4_downregulated_20C
      WBPaper00064952:Day10_vs_Day1_upregulated_20C
      WBPaper00064952:Day10_vs_Day1_upregulated_25C
      WBPaper00064952:Day10_vs_Day5_upregulated_25C
      WBPaper00064952:Day10_vs_L4_upregulated_25C
      WBPaper00064992:heat-shock_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065225:nhr-42(tm1375)_downregulated_S.aureus-infected
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065746:tmc-1(rg1003)_downregulated
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
      WBPaper00066004:ceh-14(ch3)_downregulated
      WBPaper00066038:mip-1(how5)_downregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00024671:AFD_vs_AWB_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00027342:alpha-Synuclein(A53T)_upregulated
      WBPaper00027342:alpha-Synuclein(WT)_upregulated
      WBPaper00028474:dys-1_downregulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00032948:FedUp
      WBPaper00034661:AgNPs_upregulated
      WBPaper00034739:N2lessDR1350
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035227:heat_shock_regulated
      WBPaper00035479:daf-16(RNAi)_downregulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036383:ash-2_L3_regulated
      WBPaper00037695:LD_3-day
      WBPaper00037695:WC_5-day
      WBPaper00039792:TempShiftDecrease
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040876:mir-35_downregulated
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041174:environmental
      WBPaper00041174:genotype_environment_interaction
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_3h
      WBPaper00041960:daf-16_fasting_upregulated
      WBPaper00041960:jun-1_fasting_upregulated
      WBPaper00041960:kgb-1_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042067:Cu2+_upregulated_WT
      WBPaper00042128:gei-8(ok1671)_upregulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00042574:rde-1(ne219)_OrsayVirus_upregulated
      WBPaper00043980:arsenic_upregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045263:ProLongevity-mtROS_downregulated
      WBPaper00045401:N.parisii_34h_upregulated_N2
      WBPaper00048563:L1_DD_enriched
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00049311:AgNO3_regulated
      WBPaper00050407:hsp-6(RNAi)_upregulated
      WBPaper00051448:P.aeruginosa_Liquid-Killing_upregulated
      WBPaper00056391:HT115_upregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
    Interaction (40)
  Map_info: Map: V Position: 1.92471 Error: 0.000457
    Positive: Positive_clone: T27E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4419
    Pseudo_map_position
  Reference (72)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene