WormBase Tree Display for Gene: WBGene00001796

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WBGene00001796	SMap	S_parent	Sequence	F54D1
	Identity	Version	1
		Name	CGC_name	gtl-2	Person_evidence	WBPerson51
			Sequence_name	F54D1.5
			Molecular_name	F54D1.5
				F54D1.5.1
				CE40563
			Other_name	CELE_F54D1.5	Accession_evidence	NDB	BX284604
			Public_name	gtl-2
		DB_info	Database	AceView	gene	4M45
				WormQTL	gene	WBGene00001796
				WormFlux	gene	WBGene00001796
				NDB	locus_tag	CELE_F54D1.5
				Panther	gene	CAEEL\|WormBase=WBGene00001796\|UniProtKB=Q20766
					family	PTHR13800
				NCBI	gene	178036
				RefSeq	protein	NM_069717.7
				TrEMBL	UniProtAcc	Q20766
				UniProt_GCRP	UniProtAcc	Q20766
				OMIM	gene	603576
						605692
						608961
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:25	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	gtl
		Allele (94)
		Strain	WBStrain00024196
			WBStrain00005419
			WBStrain00049842
			WBStrain00049843
		RNASeq_FPKM (74)
		GO_annotation	00069079
			00069080
			00069081
			00069082
			00069083
			00109391
			00109392
			00109393
			00109394
		Ortholog (48)
		Paralog	WBGene00001651	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00001795	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00000425	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00004149	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00008731	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00020972	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00021404	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00021408	Caenorhabditis elegans	From_analysis	WormBase-Compara
		Structured_description	Concise_description	gtl-2 encodes a predicted receptor-activated calcium channel and represents a family of calcium channels, the other two family members being gtl-1 and gon-2.	Paper_evidence	WBPaper00011683
						WBPaper00023556
					Curator_confirmed	WBPerson324
					Date_last_updated	17 Jun 2004 00:00:00
			Automated_description	Predicted to enable monoatomic cation channel activity. Predicted to be involved in monoatomic cation transmembrane transport. Located in basal plasma membrane. Expressed in excretory canal; excretory cell; hypodermis; pharyngeal muscle cell; and pharynx. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; cataract; and congenital stationary night blindness 1C. Is an ortholog of human TRPM1 (transient receptor potential cation channel subfamily M member 1); TRPM3 (transient receptor potential cation channel subfamily M member 3); and TRPM7 (transient receptor potential cation channel subfamily M member 7).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Experimental_model	DOID:0060246
		Potential_model	DOID:0110867	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:7146)
			DOID:0050534	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:7146)
			DOID:0111246	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:17994)
			DOID:83	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:17992)
	Models_disease_asserted	WBDOannot00000053
	Molecular_info	Corresponding_CDS	F54D1.5
		Corresponding_CDS_history	F54D1.5:wp57
			F54D1.5:wp167
		Corresponding_transcript	F54D1.5.1
		Other_sequence (12)
		Associated_feature	WBsf718194
			WBsf997800
			WBsf997801
			WBsf1018191
			WBsf021262
			WBsf229125
	Experimental_info	RNAi_result	WBRNAi00109632	Inferred_automatically	RNAi_primary
			WBRNAi00015597	Inferred_automatically	RNAi_primary
			WBRNAi00109535	Inferred_automatically	RNAi_primary
			WBRNAi00109341	Inferred_automatically	RNAi_primary
			WBRNAi00048282	Inferred_automatically	RNAi_primary
			WBRNAi00109244	Inferred_automatically	RNAi_primary
			WBRNAi00109438	Inferred_automatically	RNAi_primary
			WBRNAi00001304	Inferred_automatically	RNAi_primary
		Expr_pattern (8)
		Drives_construct	WBCnstr00007205
			WBCnstr00011623
			WBCnstr00013198
			WBCnstr00013672
			WBCnstr00013883
			WBCnstr00036677
			WBCnstr00042689
		Construct_product	WBCnstr00011623
			WBCnstr00013198
			WBCnstr00013672
			WBCnstr00013883
			WBCnstr00036677
			WBCnstr00042689
			WBCnstr00042690
		Microarray_results (19)
		Expression_cluster	WBPaper00031040:TGF-beta_adult_upregulated
			WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
			WBPaper00037950:all-neurons_L1-larva_expressed
			WBPaper00037950:all-neurons_L2-larva_expressed
			WBPaper00037950:AVE-neuron_L1-larva_expressed
			WBPaper00037950:bodywall-muscle_L1-larva_expressed
			WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
			WBPaper00037950:dopaminergic-neurons_larva_enriched
			WBPaper00037950:excretory-cell_L2-larva_expressed
			WBPaper00037950:excretory-cell_larva_enriched
			WBPaper00037950:excretory-cell_larva_SelectivelyEnriched
			WBPaper00037950:GABAergic-motor-neurons_larva_SelectivelyEnriched
			WBPaper00037950:germline-precursors_blastula-embryo_expressed
			WBPaper00037950:hypodermis_L3-L4-larva_expressed
			WBPaper00037950:intestine_L2-larva_expressed
			WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
			WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
			WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
			WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
			WBPaper00042561:smgl-1(RNAi)_upregulated
			WBPaper00044656:tatn-1(qd182)_upregulated
			WBPaper00044736:flat_dev_expression
			WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
			WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
			WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
			WBPaper00046805:csr-1(RNAi)_upregulated_Set1
			WBPaper00046805:csr-1(RNAi)_upregulated_Set2
			WBPaper00048923:Aging_regulated
			WBPaper00049018:ham-3(RNAi)_downregulated
			WBPaper00049635:dop-1(vs100)_downregulated
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
			WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
			WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
			WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
			WBPaper00051265:F4_hrde-1(tm1200)_upregulated
			WBPaper00053184:sma-2(rax5)_upregulated
			WBPaper00053184:sma-4(rax3)_upregulated
			WBPaper00053295:lin-22(icb38)_upregulated
			WBPaper00053302:zidovudine_24h_regulated
			WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
			WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq
			WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
			WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
			WBPaper00053368:F.oxysporum_regulated
			WBPaper00053810:nuo-6(qm200)_upregulated
			WBPaper00054493:hpl-2(tm1489)_downregulated
			WBPaper00055354:eat-2(ad1116)_downregulated
			WBPaper00055354:Rapamycin-Allantoin_downregulated
			WBPaper00055354:Rapamycin-Psora_downregulated
			WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
			WBPaper00055354:Rapamycin_downregulated
			WBPaper00055354:Rifampicin-Allantoin_downregulated
			WBPaper00055354:Rifampicin-Psora_downregulated
			WBPaper00055827:daf-2(e1370)_upregulated
			WBPaper00055862:antimycin_damt-1(gk961032)_regulated
			WBPaper00055941:nuo-6(qm200)_upregulated
			WBPaper00055971:nhl-2(ok818)_25C_downregulated
			WBPaper00056284:ints-5(RNAi)_upregulated
			WBPaper00056290:hsp-6(mg585)_upregulated
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
			WBPaper00057041:unc-70(cas983)_downregulated
			WBPaper00057143:ztf-11(RNAi)_upregulated
			WBPaper00057196:raga-1(ok386)_upregulated)
			WBPaper00058598:mex-1(or286)_upregulated
			WBPaper00058598:mex-3(eu149)_upregulated
			WBPaper00058598:spn-4(tm291)_upregulated
			WBPaper00058948:npr-8(ok1439)_downregulated_OP50
			WBPaper00058969:RIS_depleted
			WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
			WBPaper00059605:mut-16(pk710)_upregulated
			WBPaper00059664:srbc-48(ac23)_upregulated
			WBPaper00059728:5ug_cholesterol_upregulated
			WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
			WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
			WBPaper00060526:plp-1(ok2155)_upregulated
			WBPaper00060921:cat-2(e1112)_downregulated
			WBPaper00060921:tdc-1(n3419)_downregulated
			WBPaper00061340:Rectal_cell
			WBPaper00061340:rect_D
			WBPaper00061340:Y
			WBPaper00061405:S.aureus_downregulated_starvation
			WBPaper00061439:unc-30(ok613)_downregulated
			WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
			WBPaper00061527:xbx-3-DH11.5_20397
			WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_downregulated
			WBPaper00061651:ALN_enriched
			WBPaper00062159:hda-2(ok1479)_upregulated
			WBPaper00062193:daf-16(RNAi)_upregulated
			WBPaper00062193:hsf-1(RNAi)_downregulated
			WBPaper00062193:skn-1(RNAi)_downregulated
			WBPaper00062325:muscle_depleted_coding-RNA
			WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
			WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
			WBPaper00064716:paraquat_downregulated
			WBPaper00064939:vit-5(RNAi)_upregulated
			WBPaper00065074:glna(-)_upregulated
			WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
			WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
			WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C
			WBPaper00065581:hpk-1(pk1393)_upregulated
			WBPaper00065841:15_0
			WBPaper00065841:79_1
			WBPaper00065975:P-body_vs_WholeAnimal_depleted
			WBPaper00065993:glp-1(e2141)_upregulated
			WBPaper00066062:xrep-4(lax137)_upregulated
			WBPaper00066232:ash-2(RNAi)_downregulated_WT
			WBPaper00026929:Resveratrol_regulated_daf-16
			WBPaper00036286:Pattern_D
			WBPaper00041939:control_vs_EtBr-exposed_48h
			WBPaper00041939:control_vs_EtBr-exposed_51h
			WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
			WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
			WBPaper00041939:control_vs_UVC-exposed_3h
			WBPaper00041939:control_vs_UVC-exposed_48h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
			WBPaper00042258:DA1877_upregulated_GravidAdult
			WBPaper00049311:Ag-MNP_regulated
			WBPaper00053236:Starvation_regulated_GR1307
		Interaction (21)
	Map_info	Map	IV	Position	4.94064	Error	0.001769
		Positive	Positive_clone	F54D1	Inferred_automatically	From CDS info
						From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	4386
		Pseudo_map_position
	Reference (24)
	Remark	Sequence connection from Kwan CSM, Ragnauth CD and Baylis HA [021008 ck1]
		Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene