gly-2 encodes a functional homolog of mammalian UDP-N-acetylglucosamine alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V (GlcNAc-TV) which regulates polylactosamine-containing N-glycans; gly-2 is functionally interchangeable with the mammalian gene; GLY-2 is expressed in late embryos and in a subset of neurons in larvae, spermathecal and pharyngeal-intestinal valves and in specific vulval cells of adults; GLY-2 binds bovine calmodulin in vitro in a calcium-dependent manner.
Enables calmodulin binding activity and hexosyltransferase activity. Involved in protein N-linked glycosylation. Located in nucleus. Expressed in hermaphrodite gonad; neurons; pharyngeal-intestinal valve; pm8; and somatic nervous system. Is an ortholog of human MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) and MGAT5B (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.