WormBase Tree Display for Gene: WBGene00001425

WBGene00001425 Evidence: Person_evidence: WBPerson117
  SMap: S_parent: Sequence: F13B9
  Identity: Version: 1
    Name: CGC_name: fis-2 Person_evidence: WBPerson117
      Sequence_name: F13B9.8
      Molecular_name: F13B9.8
        F13B9.8.1
        CE37102
      Other_name: CELE_F13B9.8 Accession_evidence: NDB BX284606
      Public_name: fis-2
    DB_info: Database: AceView gene XI900
        WormQTL gene WBGene00001425
        WormFlux gene WBGene00001425
        NDB locus_tag CELE_F13B9.8
        Panther gene CAEEL|WormBase=WBGene00001425|UniProtKB=Q6AHP8
          family PTHR13247
        NCBI gene 184409
        RefSeq protein NM_001029389.7
        SwissProt UniProtAcc Q6AHP8
        UniProt_GCRP UniProtAcc Q6AHP8
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: fis
    Allele (32)
    Strain: WBStrain00036081
      WBStrain00036105
      WBStrain00036310
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (34)
    Paralog: WBGene00001424 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: fis-2 encodes a protein similar to the yeast and human Fis1 proteins involved in mitochondrial fission; fis-2 functions downstream of, or in parallel to, the ced-3 caspase during apoptosis and does not seem to be required for mitochondrial fission but it is possible that it may function redundantly along with fis-1 and other genes; the fis-2 protein localizes to mitochondria. Paper_evidence: WBPaper00032123
          Curator_confirmed: WBPerson324
          Date_last_updated: 22 Oct 2010 00:00:00
      Automated_description: Involved in apoptotic process. Acts upstream of or within IRE1-mediated unfolded protein response. Located in mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human FIS1 (fission, mitochondrial 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:21689)
  Molecular_info: Corresponding_CDS: F13B9.8
    Corresponding_CDS_history: F13B9.8:wp128
      F13B9.8a:wp271
    Corresponding_transcript: F13B9.8.1
    Other_sequence (2)
    Associated_feature: WBsf670828
      WBsf1006101
      WBsf1006102
      WBsf237667
  Experimental_info: RNAi_result: WBRNAi00030875 Inferred_automatically: RNAi_primary
      WBRNAi00044489 Inferred_automatically: RNAi_primary
      WBRNAi00114732 Inferred_automatically: RNAi_primary
      WBRNAi00114731 Inferred_automatically: RNAi_primary
      WBRNAi00013201 Inferred_automatically: RNAi_primary
      WBRNAi00114730 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1016157
      Expr1030850
      Expr1148438
      Expr2011793
      Expr2030031
    Drives_construct: WBCnstr00036959
    Construct_product: WBCnstr00009308
      WBCnstr00009309
      WBCnstr00036959
    Microarray_results (23)
    Expression_cluster: WBPaper00032976:non_compensated_genes
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00040209:B.thuringiensis_downregulated_MY18
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Oogenic
      WBPaper00045729:gld-2(RNAi)_upregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046858:elt-2(RNAi)_upregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050094:mes-6(bn66)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050514:CEBP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051265:F1_hrde-1(tm1200)_upregulated
      WBPaper00051265:F1_morc-1(tm6048)_upregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054192:cold-shock_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00056039:efa-6(tm3124)_downregulated
      WBPaper00056039:hda-6(ok3203)_downregulated
      WBPaper00056039:ptrn-1(tm5597)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056501:P.aeruginosa_downregulated_mitochondria-protein
      WBPaper00056826:hmc_biased
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058948:PA14_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059373:stt-3(RNAi)_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059987:Wounding_upregulated
      WBPaper00060006:nfyb-1(cu13)_upregulated_protein
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061340:Rectal_cell
      WBPaper00061340:URA_parent
      WBPaper00061527:nrde-3-tra-4_10484
      WBPaper00061651:VB01_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062293:isp-1(qm150)_upregulated
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00066085:sin-3(syb2172)_upregulated
      cgc4386_cluster_5_3
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028483:Up_mes-4_vs_WT
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Photorhabdus_luminescens_downregulated
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00032948:FedUp
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00036286:Pattern_F
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00038231:Cry5B_2-fold_upregulated
      WBPaper00038427:lin-54_germline_changed
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00049538:atfs-1(et18)_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(41_min)
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
    Interaction: WBInteraction000135884
      WBInteraction000232353
      WBInteraction000285065
      WBInteraction000323665
      WBInteraction000391317
      WBInteraction000416344
      WBInteraction000432886
      WBInteraction000463041
  Map_info: Map: X Position: -0.194898 Error: 0.00328
    Positive: Positive_clone: F13B9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5153
        4200
    Pseudo_map_position
  Reference: WBPaper00032123
    WBPaper00038491
    WBPaper00044205
    WBPaper00045775
    WBPaper00055090
    WBPaper00055144
    WBPaper00059545
    WBPaper00059627
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene