WormBase Tree Display for Gene: WBGene00001164

WBGene00001164 SMap: S_parent: Sequence: F15A2
  Identity: Version: 1
    Name: CGC_name: efn-3 Person_evidence: WBPerson893
      Sequence_name: F15A2.5
      Molecular_name: F15A2.5
        F15A2.5.1
        CE44529
      Other_name: CELE_F15A2.5 Accession_evidence: NDB BX284606
      Public_name: efn-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: efn
    Allele (35)
    Strain: WBStrain00029134
      WBStrain00005372
      WBStrain00005375
      WBStrain00005671
    RNASeq_FPKM (74)
    GO_annotation: 00064874
      00064875
      00064876
      00064877
      00064878
      00108359
    Ortholog (28)
    Paralog: WBGene00001163 Caenorhabditis elegans From_analysis (2)
      WBGene00006869 Caenorhabditis elegans From_analysis (2)
      WBGene00001165 Caenorhabditis elegans From_analysis (2)
    Structured_description: Concise_description: efn-3 encodes a potential GPI-modified ephrin that is, with EFN-2, is required for normal epidermal organization in the male tail; EFN-3, along with EFN-1 and EFN-2, activates the VAB-1 tyrosine kinase in vivo and binds it in vitro, and has a minor role in embryonic epiboly. Paper_evidence: WBPaper00003865
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable ephrin receptor binding activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in craniofrontonasal syndrome; dysostosis; and stomach cancer. Is an ortholog of human EFNB1 (ephrin B1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1934 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
      DOID:14737 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
  Molecular_info: Corresponding_CDS: F15A2.5
    Corresponding_CDS_history: F15A2.5:wp109
      F15A2.5:wp211
    Corresponding_transcript: F15A2.5.1
    Associated_feature: WBsf1007619
      WBsf1024237
  Experimental_info: RNAi_result: WBRNAi00044670 Inferred_automatically: RNAi_primary
      WBRNAi00068189 Inferred_automatically: RNAi_primary
      WBRNAi00068216 Inferred_automatically: RNAi_primary
      WBRNAi00067728 Inferred_automatically: RNAi_primary
      WBRNAi00064787 Inferred_automatically: RNAi_primary
      WBRNAi00013336 Inferred_automatically: RNAi_primary
      WBRNAi00030979 Inferred_automatically: RNAi_primary
      WBRNAi00067850 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1011959
      Expr1148644
    Drives_construct: WBCnstr00037054
    Construct_product: WBCnstr00009795
      WBCnstr00009796
      WBCnstr00037054
    Microarray_results (16)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00042477:rsr-2(RNAi)_downregulated_TilingArray
      WBPaper00044736:rising_dev_expression
      WBPaper00045390:tunicamycin_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00046805:P-granule-RNAi_upregulated_Set1
      WBPaper00047131:daf-2(e1370)_downregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050231:hermaphrodite_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050504:hrp-2(RNAi)_downregulated
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00051039:germline_enriched
      WBPaper00051558:aging_regulated
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053402:cco-1(RNAi)_downregulated
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00055013:hmg-4(RNAi)_downregulated
      WBPaper00055013:spt-16(RNAi)_downregulated
      WBPaper00055060:flr-1(RNAi)_downregulated
      WBPaper00055354:Metformin_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055386:daf-2(e1370)_downregulated
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056731:human-amylin_downregulated
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057068:numr-1(RNAi)_upregulated
      WBPaper00057143:ztf-11(RNAi)_upregulated
      WBPaper00058886:anp-1(ok608)_downregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_PA14
      WBPaper00058948:PA14_upregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_lin-40(yth27)
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_downregulated_CoCl2_6hr
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061081:E.faecalis_downregulated_N2
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061527:C03B1.14-F46C3.2
      WBPaper00062184:PA14_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(syb385)_upregulated
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_downregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064156:lipl-4(overexpress)_downregulated
      WBPaper00064494:postdauer_downregulated_WholeAnimal
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064632:daf-2(e1370)_downregulated_intestine
      WBPaper00064716:paraquat_downregulated
      WBPaper00064871:hypoxia_upregulated_F2
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065158:AFD_depleted
      WBPaper00065272:dhgd-1(tm6671)_downregulated
      WBPaper00065759:dot-1.1(knu339)_upregulated
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:18_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066232:hsf-1(RNAi)_downregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      cgc4489_group_2
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00029437:dcr-1_downregulated
      WBPaper00030985:Erwinia_carotovora_downregulated
      WBPaper00036286:Pattern_I
      WBPaper00036375:depleted_in_PVD_OLL
      WBPaper00038427:lin-54_germline_changed
      WBPaper00040184:hcf-1down_sir-2.1down_daf-2down
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00045673:colistin_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00056330:mrps-5(RNAi)_downregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
    Interaction (72)
  Map_info: Map: X Position: 12.6185 Error: 0.012221
    Positive: Positive_clone: F15A2 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4276
    Pseudo_map_position
  Reference (21)
  Remark: Sequence connection from [Wang X, Culotti JG, Pawson T]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene