WormBase Tree Display for Gene: WBGene00001161

WBGene00001161 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: Y102A5C
  Identity: Version: 1
    Name: CGC_name: efl-1 Person_evidence: WBPerson268
      Sequence_name: Y102A5C.18
      Molecular_name: Y102A5C.18
        Y102A5C.18.1
        CE20390
      Other_name: mex-2
        CELE_Y102A5C.18 Accession_evidence: NDB BX284605
      Public_name: efl-1
    DB_info: Database: AceView gene 5R440
        WormQTL gene WBGene00001161
        WormFlux gene WBGene00001161
        NDB locus_tag CELE_Y102A5C.18
        Panther gene CAEEL|WormBase=WBGene00001161|UniProtKB=G5EF11
          family PTHR12081
        NCBI gene 180133
        RefSeq protein NM_074888.7
        TrEMBL UniProtAcc G5EF11
        UniProt_GCRP UniProtAcc G5EF11
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: efl
    Allele (291)
    Legacy_information: [C.elegansII] Mutation maternal effect lethal, leading to production of excess muscle cells, like Mex-1. [JJ]
    Strain: WBStrain00027369
      WBStrain00036784
      WBStrain00022494
    RNASeq_FPKM (74)
    GO_annotation (24)
    Ortholog (37)
    Paralog: WBGene00001162 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00009899 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: efl-1 encodes a homolog of mammalian E2F that is required for embryonic asymmetry and that functions as a transcriptional repressor; during vulval development, efl-1, a class B synMuv gene, acts with class B synMuv genes dpl-1 and lin-35/Rb to antagonize receptor tyrosine kinase and Ras-mediated signaling; EFL-1 also negatively regulates the G1 to S phase cell cycle transition. Paper_evidence: WBPaper00004589
            WBPaper00004634
            WBPaper00004635
            WBPaper00005298
            WBPaper00005708
          Curator_confirmed: WBPerson1843
          Date_last_updated: 10 Nov 2005 00:00:00
      Automated_description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including embryonic digestive tract morphogenesis; negative regulation of Ras protein signal transduction; and negative regulation of vulval development. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Expressed in gonad. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate carcinoma. Is an ortholog of human E2F4 (E2F transcription factor 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10286 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3119)
      DOID:3883 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3118)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3119)
  Molecular_info: Corresponding_CDS: Y102A5C.18
    Corresponding_transcript: Y102A5C.18.1
    Other_sequence (41)
    Associated_feature: WBsf653499
      WBsf669813
      WBsf978922
      WBsf982066
      WBsf1002576
      WBsf1002577
      WBsf1021218
      WBsf1021219
    Gene_product_binds (13485)
    Transcription_factor: WBTranscriptionFactor000455
  Experimental_info: RNAi_result (52)
    Expr_pattern: Expr4031
      Expr1016766
      Expr1030739
      Expr1158669
      Expr2011189
      Expr2029425
    Drives_construct: WBCnstr00017291
    Construct_product: WBCnstr00017289
      WBCnstr00017291
      WBCnstr00017292
    Regulate_expr_cluster: WBPaper00027758:Group_I
      WBPaper00027758:Group_II
      WBPaper00027758:Group_III
      WBPaper00027758:Regulated_genes_not_in_group
      WBPaper00062056:efl-1(se1)_downregulated
      WBPaper00062056:efl-1(se1)_upregulated
    Antibody: WBAntibody00000356
    Microarray_results (20)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032031:DConiospora_upregulated_OligoArray_24h
      WBPaper00032425:up_in_lin-35
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-35_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045521:Oogenic
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046338:intestine_unique
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00046795:starvation_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:I2_grandparent
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:OLQ_grandparent
      WBPaper00061527:cyy-1_3136-hcf-1_2478
      WBPaper00061527:kle-2_4298-vrk-1
      WBPaper00062056:dpl-1(n2994)_upregulated
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062056:lin-36(we36)_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064130:Beta-Amyloid_upregulated_protein
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mes-3(bn199)_downregulated_PGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065149:lin-52(n771)_upregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00025032:cluster_32
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027758:Group_I
      WBPaper00030985:Serratia_marcesens_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00034739:N2lessDR1350
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00038060:SUMO-1_upregulated
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      WBPaper00056330:mrps-5(RNAi)_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(83_min)
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:Cluster_E
      [cgc6390]:oogenesis-enriched
    Interaction (171)
    Product_binds_matrix (12)
  Map_info: Map: V Position: 11.3775 Error: 0.003321
    Positive: Positive_clone: Y54E10BL
        Y102A5C Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4125
        5410
  Reference (76)
  Picture: WBPicture0000013091
  Remark (4)
  Method: Gene