| WBGene00001116 | SMap | S_parent | Sequence | CHROMOSOME_X |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | dyc-1 | Person_evidence | WBPerson571 |
| | | Sequence_name | C33G3.1 |
| | | Molecular_name | C33G3.1a |
| | | | C33G3.1a.1 |
| | | | CE24825 |
| | | | C33G3.1b |
| | | | CE30500 |
| | | | C33G3.1b.1 |
| | | | C33G3.1b.2 |
| | | Other_name | CELE_C33G3.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | dyc-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | dyc |
| | Allele (289) |
| | Strain | WBStrain00024336 |
| | RNASeq_FPKM (74) |
| | GO_annotation (13) |
| | Ortholog (41) |
| | Paralog | WBGene00000420 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000894 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00009930 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002176 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00003830 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | dyc-1 encodes a homolog of murine CAPON, a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95; DYC-1 is expressed in muscle, and is required for a dystrophin-related function in muscle. | Paper_evidence | WBPaper00004383 |
| | | | | | WBPaper00004410 |
| | | | | | WBPaper00013014 |
| | | | | | WBPaper00013610 |
| | | | | | WBPaper00017840 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | A structural constituent of muscle. Involved in several processes, including muscle cell cellular homeostasis; regulation of egg-laying behavior; and sarcomere organization. Located in axon and striated muscle dense body. Part of dystrophin-associated glycoprotein complex. Expressed in SDQL; SDQR; body wall musculature; head neurons; and vulval muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in nephrotic syndrome type 22. Is an ortholog of human NOS1AP (nitric oxide synthase 1 adaptor protein). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:11723 | Homo sapiens | Paper_evidence | WBPaper00031344 |
| | | | | | WBPaper00004383 |
| | | | | Accession_evidence | OMIM | 310200 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 18 May 2017 00:00:00 |
| | Potential_model | DOID:0112268 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16859) |
| | Disease_relevance | Mutations in human dystrophin are associated with the Duchenne and Becker types of muscular dystrophy, that affect skeletal muscles used for movement, and heart (cardiac) muscle; the genetic model for progressive myopathy in C. elegans is a mutant of the elegans dystrophin ortholog, dys-1, combined with a mutation in hlh-1, the MyoD ortholog, (dys-1(cx18);hlh-1(cc561ts), these animals display time-dependent muscle degeneration; this model has been used to discover genes that play a role in muscle degeneration including dyc-1, the elegans ortholog of neuronal nitric oxide synthase adaptor protein (NOS1AP); dyc-1 loss of function mutations (cx5, cx32), show locomotion defects like hyperactivity and hypercontraction and in combination with the hlh-1 mutation show time-dependent muscle degeneration; when over-expressed dyc-1 can partially compensate for the loss of dystrophin in the dys-1; hlh-1 double mutants; further the muscle dense body expressed dyc-1 interacts with zyx-1, the ortholog of the human focal adhesion protein zyxin, via conserved domains; these studies indicate that DYC-1 may function together with DYS-1 and other proteins, and the dense body may be the site of the primary events of muscle degeneration occurring in the absence of dystrophin. | Homo sapiens | Paper_evidence | WBPaper00004383 |
| | | | | Accession_evidence | OMIM | 605551 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 18 May 2017 00:00:00 |
| Modifies_disease | DOID:11723 |
| Modifies_disease_in_annotation | WBDOannot00000421 |
| Models_disease_asserted | WBDOannot00000114 |
| | WBDOannot00000287 |
| Molecular_info (4) |
| Experimental_info | RNAi_result | WBRNAi00029472 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00041784 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00041783 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00012178 |
| | | WBCnstr00013251 |
| | | WBCnstr00013252 |
| | | WBCnstr00013253 |
| | | WBCnstr00013821 |
| | | WBCnstr00019119 |
| | | WBCnstr00037077 |
| | | WBCnstr00039395 |
| | Construct_product | WBCnstr00013251 |
| | | WBCnstr00013252 |
| | | WBCnstr00013253 |
| | | WBCnstr00037077 |
| | Antibody | WBAntibody00001353 |
| | Microarray_results (31) |
| | Expression_cluster | WBPaper00027339:daf-12(rh273)_downregulated |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00033070:Rhine_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_embryo_enriched |
| | | WBPaper00037950:AVA-neuron_embryo_SelectivelyEnriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_embryo_enriched |
| | | WBPaper00037950:AVE-neuron_embryo_SelectivelyEnriched |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_SelectivelyEnriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:alovudine_72h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056284:ints-1(RNAi)_downregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058711:skn-1(lax188)_upregulated |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060871:M.humicola-infection_24h_regulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:mu_int_mu_anal |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RMD |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061527:tub-2_4713-daf-2_5288 |
| | | WBPaper00061651:AVE_enriched |
| | | WBPaper00061651:AVL_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065841:14_2 |
| | | WBPaper00065841:20_0 |
| | | WBPaper00065841:40_0 |
| | | WBPaper00065841:49_0 |
| | | WBPaper00065841:68_0 |
| | | WBPaper00065841:73_0 |
| | | WBPaper00065841:83_0 |
| | | WBPaper00065841:93_0 |
| | | WBPaper00065841:97_0 |
| | | WBPaper00065841:98_0 |
| | | WBPaper00065841:100_0 |
| | | WBPaper00065841:108_0 |
| | | WBPaper00065841:109_0 |
| | | WBPaper00065841:118_0 |
| | | WBPaper00065841:119_0 |
| | | WBPaper00065841:121_0 |
| | | WBPaper00065841:130_0 |
| | | WBPaper00065841:132_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4489_group_18 |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00045865:biofilm_downregulated_B |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (21) |
| Map_info | Map | X | Position | 16.1507 | Error | 0.110522 |
| | Positive | Positive_clone | C33G3 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4153 |
| | | | 4271 |
| | Pseudo_map_position |
| Reference (21) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
