WormBase Tree Display for Disease_model_annotation: WBDOannot00000421
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| WBDOannot00000421 | Disease_term | DOID:11723 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Strain | WBStrain00024340 | |
| Asserted_gene | WBGene00001131 | ||
| WBGene00001948 | |||
| Association_type | is_model_of | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Modifier_info | Modifier_gene | WBGene00001116 | |
| Modifier_association_type | condition_ameliorated_by | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00004383 | ||
| Disease_model_description | Dystrophin is the product of the gene that is mutated in Duchenne muscular dystrophy (DMD), a progressive neuromuscular disease; double mutant worms in dys-1 and hlh-1 displayed impaired locomotion and egg laying (phenotypes not seen in the single mutants) and extensive muscle degeneration; when overexpressed, the dyc-1 gene (shares similarities with the mammalian neural nitric oxide synthase (nNOS)-binding protein CAPON) partially suppressed the dys-1; hlh-1 phenotype. | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 17 May 2017 00:00:00 |
