WormBase Tree Display for Gene: WBGene00001116
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| WBGene00001116 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | dyc-1 | Person_evidence | WBPerson571 | |||||
| Sequence_name | C33G3.1 | ||||||||
| Molecular_name | C33G3.1a | ||||||||
| C33G3.1a.1 | |||||||||
| CE24825 | |||||||||
| C33G3.1b | |||||||||
| CE30500 | |||||||||
| C33G3.1b.1 | |||||||||
| C33G3.1b.2 | |||||||||
| Other_name | CELE_C33G3.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | dyc-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dyc | ||||||||
| Allele (289) | |||||||||
| Strain | WBStrain00024336 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00000420 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000894 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00009930 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00002176 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003830 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | dyc-1 encodes a homolog of murine CAPON, a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95; DYC-1 is expressed in muscle, and is required for a dystrophin-related function in muscle. | Paper_evidence | WBPaper00004383 | |||||
| WBPaper00004410 | |||||||||
| WBPaper00013014 | |||||||||
| WBPaper00013610 | |||||||||
| WBPaper00017840 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | A structural constituent of muscle. Involved in several processes, including muscle cell cellular homeostasis; regulation of egg-laying behavior; and sarcomere organization. Located in axon and striated muscle dense body. Part of dystrophin-associated glycoprotein complex. Expressed in SDQL; SDQR; body wall musculature; head neurons; and vulval muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in nephrotic syndrome type 22. Is an ortholog of human NOS1AP (nitric oxide synthase 1 adaptor protein). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:11723 | Homo sapiens | Paper_evidence | WBPaper00031344 | ||||
| WBPaper00004383 | |||||||||
| Accession_evidence | OMIM | 310200 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 May 2017 00:00:00 | ||||||||
| Potential_model | DOID:0112268 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16859) | |||||
| Disease_relevance | Mutations in human dystrophin are associated with the Duchenne and Becker types of muscular dystrophy, that affect skeletal muscles used for movement, and heart (cardiac) muscle; the genetic model for progressive myopathy in C. elegans is a mutant of the elegans dystrophin ortholog, dys-1, combined with a mutation in hlh-1, the MyoD ortholog, (dys-1(cx18);hlh-1(cc561ts), these animals display time-dependent muscle degeneration; this model has been used to discover genes that play a role in muscle degeneration including dyc-1, the elegans ortholog of neuronal nitric oxide synthase adaptor protein (NOS1AP); dyc-1 loss of function mutations (cx5, cx32), show locomotion defects like hyperactivity and hypercontraction and in combination with the hlh-1 mutation show time-dependent muscle degeneration; when over-expressed dyc-1 can partially compensate for the loss of dystrophin in the dys-1; hlh-1 double mutants; further the muscle dense body expressed dyc-1 interacts with zyx-1, the ortholog of the human focal adhesion protein zyxin, via conserved domains; these studies indicate that DYC-1 may function together with DYS-1 and other proteins, and the dense body may be the site of the primary events of muscle degeneration occurring in the absence of dystrophin. | Homo sapiens | Paper_evidence | WBPaper00004383 | |||||
| Accession_evidence | OMIM | 605551 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 May 2017 00:00:00 | ||||||||
| Modifies_disease | DOID:11723 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00000421 | ||||||||
| Models_disease_asserted | WBDOannot00000114 | ||||||||
| WBDOannot00000287 | |||||||||
| Molecular_info | Corresponding_CDS | C33G3.1a | |||||||
| C33G3.1b | |||||||||
| Corresponding_transcript | C33G3.1a.1 | ||||||||
| C33G3.1b.1 | |||||||||
| C33G3.1b.2 | |||||||||
| Other_sequence (13) | |||||||||
| Associated_feature (24) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00029472 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00041784 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041783 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00012178 | ||||||||
| WBCnstr00013251 | |||||||||
| WBCnstr00013252 | |||||||||
| WBCnstr00013253 | |||||||||
| WBCnstr00013821 | |||||||||
| WBCnstr00019119 | |||||||||
| WBCnstr00037077 | |||||||||
| WBCnstr00039395 | |||||||||
| Construct_product | WBCnstr00013251 | ||||||||
| WBCnstr00013252 | |||||||||
| WBCnstr00013253 | |||||||||
| WBCnstr00037077 | |||||||||
| Antibody | WBAntibody00001353 | ||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (167) | |||||||||
| Interaction (21) | |||||||||
| Map_info | Map | X | Position | 16.1507 | Error | 0.110522 | |||
| Positive | Positive_clone | C33G3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4153 | |||||||
| 4271 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (21) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
