WormBase Tree Display for Gene: WBGene00002176
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| WBGene00002176 | Evidence | Person_evidence | WBPerson1068 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F56D12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | jip-1 | Person_evidence | WBPerson1315 | |||||
| Sequence_name | F56D12.4 | ||||||||
| Molecular_name (18) | |||||||||
| Other_name | CELE_F56D12.4 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | jip-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00002176 | |||||
| WormFlux | gene | WBGene00002176 | |||||||
| NDB | locus_tag | CELE_F56D12.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002176|UniProtKB=G4RZC8 | |||||||
| family | PTHR11232 | ||||||||
| NCBI | gene | 173513 | |||||||
| RefSeq | protein | NM_001420586.1 | |||||||
| NM_001038242.6 | |||||||||
| NM_001038243.6 | |||||||||
| NM_001377692.2 | |||||||||
| NM_001420585.1 | |||||||||
| NM_001377691.2 | |||||||||
| TREEFAM | TREEFAM_ID | TF325073 | |||||||
| TrEMBL | UniProtAcc | A0A5S9MNX6 | |||||||
| A0A5S9MN04 | |||||||||
| G4RZC8 | |||||||||
| A0A5S9MQ27 | |||||||||
| G4RZC9 | |||||||||
| O16643 | |||||||||
| UniProt_GCRP | UniProtAcc | G4RZC8 | |||||||
| OMIM | gene | 604641 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | jip | ||||||||
| Allele (478) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00004169 | ||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00000420 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000894 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001116 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00009930 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003830 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | JIP-1 is partly similar to the human gene ISLET-BRAIN 1 (MAPK8IP1; OMIM:604641), which when mutated leads to type II diabetes. | Curator_confirmed | WBPerson1823 | |||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enriched in head mesodermal cell; neurons; pharynx; retrovesicular ganglion; and ventral nerve cord based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including sir-2.1; sek-1; and pgl-1 based on microarray and RNA-seq studies. Is affected by seven chemicals including stavudine; allantoin; and metformin based on RNA-seq and microarray studies. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Human MAPK8IP1 enables MAP-kinase scaffold activity and kinesin binding activity. Is predicted to encode a protein with the following domains: PH-like domain superfamily; Phosphotyrosine interaction domain (PTB/PID); SH3-like domain superfamily; SH3 domain; PTB/PI domain; and Variant SH3 domain. Is an ortholog of human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6882) | ||||
| Molecular_info | Corresponding_CDS | F56D12.4a | |||||||
| F56D12.4b | |||||||||
| F56D12.4c | |||||||||
| F56D12.4d | |||||||||
| F56D12.4e | |||||||||
| F56D12.4f | |||||||||
| Corresponding_CDS_history | F56D12.4:wp97 | ||||||||
| F56D12.4:wp112 | |||||||||
| F56D12.4:wp127 | |||||||||
| F56D12.4:wp149 | |||||||||
| F56D12.4a:wp274 | |||||||||
| Corresponding_transcript | F56D12.4a.1 | ||||||||
| F56D12.4b.1 | |||||||||
| F56D12.4c.1 | |||||||||
| F56D12.4d.1 | |||||||||
| F56D12.4e.1 | |||||||||
| F56D12.4f.1 | |||||||||
| Other_sequence (50) | |||||||||
| Associated_feature (20) | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr1027659 | ||||||||
| Expr1031271 | |||||||||
| Expr1152447 | |||||||||
| Expr2012883 | |||||||||
| Expr2031117 | |||||||||
| Microarray_results (41) | |||||||||
| Expression_cluster (174) | |||||||||
| Interaction (19) | |||||||||
| Map_info | Map | II | Position | -15.4846 | Error | 0.004771 | |||
| Positive | Positive_clone | F56D12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00018823 | ||||||||
| WBPaper00024295 | |||||||||
| WBPaper00025342 | |||||||||
| WBPaper00028624 | |||||||||
| WBPaper00030247 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00042589 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
