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WormBase Tree Display for Gene: WBGene00001116

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Name Class

WBGene00001116SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_namedyc-1Person_evidenceWBPerson571
Sequence_nameC33G3.1
Molecular_nameC33G3.1a
C33G3.1a.1
CE24825
C33G3.1b
CE30500
C33G3.1b.1
C33G3.1b.2
Other_nameCELE_C33G3.1Accession_evidenceNDBBX284606
Public_namedyc-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:23WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classdyc
AlleleWBVar00054742Inferred_automaticallyFrom strain object: LS396
WBVar01205759
WBVar01205760
WBVar01205762
WBVar01499887
WBVar01499519
WBVar01493814
WBVar01205763
WBVar02077511
WBVar01205764
WBVar01499888
WBVar01205765
WBVar01205766
WBVar01205767
WBVar01205768
WBVar01205769
WBVar01205770
WBVar01499710
WBVar01205771
WBVar01205772
WBVar01205773
WBVar01205774
WBVar01205775
WBVar01205776
WBVar01205777
WBVar01205778
WBVar01205779
WBVar01205780
WBVar01941891
WBVar01941892
WBVar01941893
WBVar01941894
WBVar01941895
WBVar01941896
WBVar01941897
WBVar02005440
WBVar01941898
WBVar01941899
WBVar01889207
WBVar02056570
WBVar01946241
WBVar01946242
WBVar01946243
WBVar01679365
WBVar01572738
WBVar01679366
WBVar01946244
WBVar01572739
WBVar01981602
WBVar01679367
WBVar01946245
WBVar01572740
WBVar01946246
WBVar01679368
WBVar01489621
WBVar01572741
WBVar02078294
WBVar01572742
WBVar01679369
WBVar01572743
WBVar01679370
WBVar01572744
WBVar01602421
WBVar01572745
WBVar01492017
WBVar01572746
WBVar01572747
WBVar02088443
WBVar01572748
WBVar01572749
WBVar01572750
WBVar01572751
WBVar01572752
WBVar01572753
WBVar01817164
WBVar02075321
WBVar01787865
WBVar01787866
WBVar01787867
WBVar01787868
WBVar01787869
WBVar01472311
WBVar01988122
WBVar02011656
WBVar01787870
WBVar01472312
WBVar01472313
WBVar01499592
WBVar00249414
WBVar01205673
WBVar01205674
WBVar01703973
WBVar01205675
WBVar01703974
WBVar01205676
WBVar01205677
WBVar01703975
WBVar01205678
WBVar01703976
WBVar01205679
WBVar01703977
WBVar01205680
WBVar01703978
WBVar01825332
WBVar01703979
WBVar01205681
WBVar01825333
WBVar01825334
WBVar01205682
WBVar01914288
WBVar00054717
WBVar01825335
WBVar01205683
WBVar01205684
WBVar01825336
WBVar01205685
WBVar01205686
WBVar00523347
WBVar01205687
WBVar00523348
WBVar00523349
WBVar01205688
WBVar00254424
WBVar00523350
WBVar01205689
WBVar00066884
WBVar01205690
WBVar00523351
WBVar00523352
WBVar01205691
WBVar00523353
WBVar02076317
WBVar01205692
WBVar01205693
WBVar00523354
WBVar02076318
WBVar01205694
WBVar00523355
WBVar01205695
WBVar00523356
WBVar01205696
WBVar00523357
WBVar00523358
WBVar00101986
WBVar01205697
WBVar00523359
WBVar01205698
WBVar00523360
WBVar00264925
WBVar00101988
WBVar01205699
WBVar01622069
WBVar01205700
WBVar00523361
WBVar01205701
WBVar00523362
WBVar01622070
WBVar00101990
WBVar00084519
WBVar01205702
WBVar00084520
WBVar00523363
WBVar00218491
WBVar00084521
WBVar01205703
WBVar00523364
WBVar01544747
WBVar00523365
WBVar00084522
WBVar01488052
WBVar01205704
WBVar00523366
WBVar00084523
WBVar01488053
WBVar01205705
WBVar01544748
WBVar00523367
WBVar00084524
WBVar01544749
WBVar01205706
WBVar01205707
WBVar00523368
WBVar00218496
WBVar00084525
WBVar01544750
WBVar00084526
WBVar00523369
WBVar01205708
WBVar01552529
WBVar00084527
WBVar01205709
WBVar00523370
WBVar01820570
WBVar01205710
WBVar01552530
WBVar00084528
WBVar00523371
WBVar01205711
WBVar01552531
WBVar00523372
WBVar00084529
WBVar00084530
WBVar01552532
WBVar01205712
WBVar00523373
WBVar00084531
WBVar01205713
WBVar01552533
WBVar00084532
WBVar01552534
WBVar01205714
WBVar01552535
WBVar00084533
WBVar01205715
WBVar00254451
WBVar00084534
WBVar01205716
WBVar01955165
WBVar01552536
WBVar01205717
WBVar01955166
WBVar01552537
WBVar00084535
WBVar01205718
WBVar01552538
WBVar01955167
WBVar00084536
WBVar01955168
WBVar01205719
WBVar00084537
WBVar01205720
WBVar01955169
WBVar00084538
WBVar01205721
WBVar00084539
WBVar01760044
WBVar01205722
WBVar01760045
WBVar00084540
WBVar01205723
WBVar01760046
WBVar01205724
WBVar01760047
WBVar01205725
WBVar01205726
WBVar01205727
WBVar01205728
WBVar01205729
WBVar01205730
WBVar01205731
WBVar01205732
WBVar01205733
WBVar01205734
WBVar00218530
WBVar01205735
WBVar01205736
WBVar01205737
WBVar01205738
WBVar01205739
WBVar02075429
WBVar01205740
WBVar02140505
WBVar01205741
WBVar01205742
WBVar01205743
WBVar01205744
WBVar01205745
WBVar01205746
WBVar00218552
WBVar01205747
WBVar01205748
WBVar01205749
WBVar01205750
WBVar01205751
WBVar02052625
WBVar01205752
WBVar01205753
WBVar00218565
WBVar02027603
WBVar01205754
WBVar01205755
WBVar02027604
WBVar01498960
WBVar01205756
WBVar02027605
WBVar01205757
WBVar01500067
WBVar01205758
WBVar00218573
StrainWBStrain00024336
RNASeq_FPKM (74)
GO_annotation (13)
Ortholog (41)
ParalogWBGene00000420Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000894Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00009930Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002176Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003830Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptiondyc-1 encodes a homolog of murine CAPON, a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95; DYC-1 is expressed in muscle, and is required for a dystrophin-related function in muscle.Paper_evidenceWBPaper00004383
WBPaper00004410
WBPaper00013014
WBPaper00013610
WBPaper00017840
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionA structural constituent of muscle. Involved in several processes, including muscle cell cellular homeostasis; regulation of egg-laying behavior; and sarcomere organization. Located in axon and striated muscle dense body. Part of dystrophin-associated glycoprotein complex. Expressed in SDQL; SDQR; body wall musculature; head neurons; and vulval muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in nephrotic syndrome type 22. Is an ortholog of human NOS1AP (nitric oxide synthase 1 adaptor protein).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:11723Homo sapiensPaper_evidenceWBPaper00031344
WBPaper00004383
Accession_evidenceOMIM310200
Curator_confirmedWBPerson324
Date_last_updated18 May 2017 00:00:00
Potential_modelDOID:0112268Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:16859)
Disease_relevanceMutations in human dystrophin are associated with the Duchenne and Becker types of muscular dystrophy, that affect skeletal muscles used for movement, and heart (cardiac) muscle; the genetic model for progressive myopathy in C. elegans is a mutant of the elegans dystrophin ortholog, dys-1, combined with a mutation in hlh-1, the MyoD ortholog, (dys-1(cx18);hlh-1(cc561ts), these animals display time-dependent muscle degeneration; this model has been used to discover genes that play a role in muscle degeneration including dyc-1, the elegans ortholog of neuronal nitric oxide synthase adaptor protein (NOS1AP); dyc-1 loss of function mutations (cx5, cx32), show locomotion defects like hyperactivity and hypercontraction and in combination with the hlh-1 mutation show time-dependent muscle degeneration; when over-expressed dyc-1 can partially compensate for the loss of dystrophin in the dys-1; hlh-1 double mutants; further the muscle dense body expressed dyc-1 interacts with zyx-1, the ortholog of the human focal adhesion protein zyxin, via conserved domains; these studies indicate that DYC-1 may function together with DYS-1 and other proteins, and the dense body may be the site of the primary events of muscle degeneration occurring in the absence of dystrophin.Homo sapiensPaper_evidenceWBPaper00004383
Accession_evidenceOMIM605551
Curator_confirmedWBPerson324
Date_last_updated18 May 2017 00:00:00
Modifies_diseaseDOID:11723
Modifies_disease_in_annotationWBDOannot00000421
Models_disease_assertedWBDOannot00000114
WBDOannot00000287
Molecular_infoCorresponding_CDSC33G3.1a
C33G3.1b
Corresponding_transcriptC33G3.1a.1
C33G3.1b.1
C33G3.1b.2
Other_sequence (13)
Associated_feature (24)
Experimental_infoRNAi_resultWBRNAi00029472Inferred_automaticallyRNAi_primary
WBRNAi00041784Inferred_automaticallyRNAi_primary
WBRNAi00041783Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_constructWBCnstr00012178
WBCnstr00013251
WBCnstr00013252
WBCnstr00013253
WBCnstr00013821
WBCnstr00019119
WBCnstr00037077
WBCnstr00039395
Construct_productWBCnstr00013251
WBCnstr00013252
WBCnstr00013253
WBCnstr00037077
AntibodyWBAntibody00001353
Microarray_results (31)
Expression_cluster (167)
Interaction (21)
Map_infoMapXPosition16.1507Error0.110522
PositivePositive_cloneC33G3Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4153
4271
Pseudo_map_position
Reference (21)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene