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WormBase Tree Display for Gene: WBGene00000939

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Name Class

WBGene00000939EvidencePaper_evidenceWBPaper00004772
SMapS_parentSequenceK12H4
IdentityVersion1
NameCGC_namedcr-1Person_evidenceWBPerson419
Sequence_nameK12H4.8
Molecular_nameK12H4.8
K12H4.8.1
CE47418
Other_namelet-740CGC_data_submission
eri-4Paper_evidenceWBPaper00035199
CELE_K12H4.8Accession_evidenceNDBBX284603
Public_namedcr-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:22WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classdcr
Allele (78)
Legacy_informationHomozygous s2624 and s2795 each develope into sterile adults.
Strain (13)
RNASeq_FPKM (74)
GO_annotation (61)
Ortholog (58)
ParalogWBGene00001090Caenorhabditis elegansFrom_analysisTreeFam
WBGene00008400Caenorhabditis elegansFrom_analysisTreeFam
Structured_descriptionConcise_descriptiondcr-1 encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; DCR-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 functions to process pre-miRNAs into their mature, 22-nt form; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing; DCR-1 is also required for fragmention of chromosomal DNA during apoptosis, and undergoes a CED-3 protease-mediated conversion from a ribonuclease to a deoxyribonuclease.Paper_evidenceWBPaper00004424
WBPaper00004923
WBPaper00005368
WBPaper00036025
WBPaper00024573
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated03 Feb 2014 00:00:00
Automated_descriptionEnables deoxyribonuclease I activity and ribonuclease III activity. Involved in several processes, including nucleic acid metabolic process; olfactory learning; and positive regulation of primary miRNA processing. Acts upstream of or within defense response to Gram-positive bacterium. Located in cytosol and nucleus. Expressed in germ line; intestine; neurons; and somatic cell. Human ortholog(s) of this gene implicated in several diseases, including DICER1 syndrome; gastrointestinal system cancer (multiple); and multinodular goiter. Is an ortholog of human DICER1 (dicer 1, ribonuclease III).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17098)
DOID:4769Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17098)
DOID:0050745Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17098)
DOID:0080615Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17098)
DOID:0050489Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17098)
DOID:10534Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17098)
DOID:0081063Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17098)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17098)
Molecular_infoCorresponding_CDSK12H4.8
Corresponding_CDS_historyK12H4.8:wp230
Corresponding_transcriptK12H4.8.1
Other_sequence (58)
Associated_featureWBsf651241
WBsf667129
WBsf227077
WBsf227078
Experimental_infoRNAi_result (65)
Expr_patternExpr10581
Expr11565
Expr12215
Expr12472
Expr1022725
Expr1030586
Expr1154395
Expr2010807
Expr2029044
Drives_constructWBCnstr00005999
WBCnstr00006000
WBCnstr00006001
WBCnstr00017007
WBCnstr00020414
WBCnstr00037186
Construct_product (13)
Regulate_expr_clusterWBPaper00027057:DCR-1_interacting_adult
WBPaper00027057:DCR-1_interacting_embryo
WBPaper00029437:dcr-1_downregulated
WBPaper00029437:dcr-1_upregulated
WBPaper00059490:dcr-1(m9375)_downregulated
WBPaper00059490:dcr-1(m9375)_upregulated
AntibodyWBAntibody00000418
WBAntibody00001054
WBAntibody00001326
WBAntibody00001327
WBAntibody00001490
WBAntibody00002257
WBAntibody00002600
Microarray_results (18)
Expression_clusterWBPaper00027057:DCR-1_interacting_embryo
WBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00033065:isp-1-1(qm150)_upregulated
WBPaper00034755:ALG-1_interacting
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_8
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_downregulated_N2
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00049979:R-astaxanthin_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050743:elli-1(sam-3)_upregulated
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00051039:germline_enriched
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051265:F4_hrde-1(tm1200)_upregulated
WBPaper00051265:F4_morc-1(tm6048)_upregulated
WBPaper00051310:LIN-41_interacting
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053289:DREAM-target
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
WBPaper00055226:ADR-2_target_N2
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055648:germline_expressed
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00057288:Cold_downregulated_protein
WBPaper00057288:Cold_downregulated_transcript
WBPaper00058598:sin-3(tm1276)_upregulated
WBPaper00058886:anp-1(ok608)_downregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
WBPaper00059664:srbc-48(ac23)_downregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060445:ikb-1(nr2027)_upregulated_L4
WBPaper00060445:nfki-1(cer1)_upregulated_L4
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00061203:sin-3(tm1276)_downregulated
WBPaper00061203:spr-1(ok2144)_downregulated
WBPaper00061340:Excretory_cell_parent
WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
WBPaper00061340:RIA_parent
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
WBPaper00061479:HDA-1_interacting_protein
WBPaper00061527:npp-6-mtr-4_21425
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00062056:lin-35(n745)_upregulated
WBPaper00062056:lin-36(we31)_upregulated
WBPaper00062056:lin-36(we36)_upregulated
WBPaper00062056:lin-37(n758)_upregulated
WBPaper00062123:DEPS-1_interacting
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00064071:NHR-49_interacting
WBPaper00064080:miR-2_miRNA_interacting
WBPaper00064080:miR-58_miRNA_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064505:tamoxifen_upregulated
WBPaper00064716:paraquat_upregulated
WBPaper00065149:lin-52(n771)_upregulated
WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
WBPaper00025032:cluster_197
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00029437:dcr-1_downregulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00035905:FBF-1_Associated
WBPaper00036286:Pattern_B
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040823:alg-1(gk214)_downregulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040963:TA300_down
WBPaper00041002:HF_3d_2.0mM_Down
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00053688:E.faecium_upregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:cluster_27
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(41_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc6390]:Cluster_F
[cgc6390]:intrinsic
Interaction (219)
WBProcessWBbiopr:00000014
WBbiopr:00000039
WBbiopr:00000057
WBbiopr:00000073
WBbiopr:00000081
Map_infoMapIIIPosition-0.385999Error0.003601
Hide_underWBGene00002843
PositiveInside_rearrnDf20
sDp3
sDp8
Positive_cloneK12H4Inferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeOutside_rearrsDf128
Mapping_data (2)
Reference (124)
RemarkThe let-740 gene is the same gene as dcr-1 and they therefore have been merged following advice from the CGC. let-740 is now an other name for dcr-1 [krb 030508]
MethodGene