WormBase Tree Display for Gene: WBGene00000868

WBGene00000868 SMap: S_parent: Sequence: T06E6
  Identity: Version: 1
    Name: CGC_name: cyb-3
      Sequence_name: T06E6.2
      Molecular_name: T06E6.2a
        T06E6.2a.1
        CE45171
        T06E6.2b
        CE45189
        T06E6.2a.2
        T06E6.2b.1
      Other_name: cyb-2
        CELE_T06E6.2 Accession_evidence: NDB BX284605
      Public_name: cyb-3
    DB_info: Database: AceView gene 5P877
        WormQTL gene WBGene00000868
        WormFlux gene WBGene00000868
        NDB locus_tag CELE_T06E6.2
        Panther gene CAEEL|WormBase=WBGene00000868|UniProtKB=Q10654
          family PTHR10177
        NCBI gene 180040
        RefSeq protein NM_074424.10
            NM_001028941.4
        SwissProt UniProtAcc Q10654
        TREEFAM TREEFAM_ID TF101001
        UniProt_GCRP UniProtAcc Q10654
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyb
    Allele (48)
    Legacy_information: [C.elegansII] NMK. Encodes predicted cyclin B. [KB]
    Strain: WBStrain00035729
      WBStrain00005799
      WBStrain00054803
      WBStrain00054976
      WBStrain00048566
    RNASeq_FPKM (74)
    GO_annotation (30)
    Ortholog (55)
    Paralog (13)
    Structured_description: Concise_description: cyb-3 encodes one of four C. elegans cyclin B family members that is most closely related to the B3-type cyclins; cyb-3 is required for a number of dynein-related mitotic processes and specifically for initiation of anaphase chromosome segregation; cyb-3 is also required for completion of meiosis II and proper pronuclear migration, centrosome maturation, and pronuclear condensation in the fertilized oocyte; cyb-3 is also essential for embryonic viability. Paper_evidence: WBPaper00004540
            WBPaper00005598
            WBPaper00005654
            WBPaper00037839
          Curator_confirmed: WBPerson48
            WBPerson1843
            WBPerson567
          Date_last_updated: 01 Apr 2011 00:00:00
      Automated_description: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including chromosome organization; regulation of cell cycle; and sexual reproduction. Acts upstream of or within nematode male tail tip morphogenesis. Located in cytoplasm and nucleus. Expressed in several structures, including EMS; Psub2; germ cell; germ line; and male gonad. Is an ortholog of human CCNB3 (cyclin B3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T06E6.2a
      T06E6.2b
    Corresponding_CDS_history: T06E6.2:wp51
      T06E6.2a:wp216
      T06E6.2b:wp216
    Corresponding_transcript: T06E6.2a.1
      T06E6.2a.2
      T06E6.2b.1
    Other_sequence (16)
    Associated_feature (16)
  Experimental_info: RNAi_result (35)
    Expr_pattern (15)
    Drives_construct: WBCnstr00037236
      WBCnstr00041763
    Construct_product: WBCnstr00001758
      WBCnstr00015134
      WBCnstr00015136
      WBCnstr00037236
      WBCnstr00041763
    Antibody: WBAntibody00001667
      WBAntibody00002046
      WBAntibody00002047
      WBAntibody00002745
    Microarray_results (28)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032097:CGH-1-associated-mRNA
      WBPaper00035269:cde-1_regulated
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:CEP-sheath-cells_adult_enriched
      WBPaper00037950:CEP-sheath-cells_adult_SelectivelyEnriched
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(gk119)_downregulated
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045050:csr-1(hypomorph)_downregulated
      WBPaper00045050:drh-3 (ne4253)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045618:puf-8_downregulated
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050193:cec-4(ok3124)_downregulated_L1
      WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F1_morc-1(tm6048)_downregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_embryo_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00054191:H3.3(null)_L1_upregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057154:HeatShock_upregulated_miRNA-target
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058886:anp-1(ok608)_downregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059174:MEG-3_interacting
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_L4
      WBPaper00059763:neuron_expressed
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061045:Y56A3A.22(cck200)_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:ADA_ADE_grandparent
      WBPaper00061340:Body_wall_muscle
      WBPaper00061340:Ciliated_amphid_neuron
      WBPaper00061340:Ciliated_non_amphid_neuron
      WBPaper00061340:Excretory_cell_parent
      WBPaper00061340:I2_grandparent
      WBPaper00061340:Neuroblast_AFD_RMD
      WBPaper00061340:Neuroblast_ALA_RMED
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:Neuroblast_AWC_SAAVx
      WBPaper00061340:OLQ_grandparent
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061340:Parents_of_U_F_B_DVA
      WBPaper00061340:Parent_of_AMsh_URB
      WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V
      WBPaper00061340:Parent_of_tail_spike_and_hyp10
      WBPaper00061340:PLM_ALN_great_grandparent
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:pch-2-B0393.3
      WBPaper00061527:pcn-1-cyb-3_17196
      WBPaper00061699:daf-18(ok480)_upregulated
      WBPaper00061753:csr-1(tor159)_downregulated_25C
      WBPaper00062056:lin-36(we36)_upregulated
      WBPaper00062118:neural-HSF-1_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062456:doxycycline_downregulated_CB4856_transcript
      WBPaper00062590:Aging_upregulated_neuron
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065315:mating_upregulated_Day2-7
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065841:3_0
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_5_2
      cgc4489_group_2
      WBPaper00005124:estrogen_10-5M_regulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00027342:alpha-Synuclein(WT)_upregulated
      WBPaper00027758:Group_I
      WBPaper00028948:cep-1(gk138)+UV_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00034739:N2lessDR1350
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00039866:SAM_daf-19_upregulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040426:CYD-1_CDK-4_upregulated
      WBPaper00040426:CYE-1_CDK-2AF_upregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:TA300_down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00049311:AgNO3_regulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      WBPaper00056330:mrps-5(RNAi)_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(122_min)
      [cgc5767]:expression_class_E_pi(66_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:Cluster_E
      [cgc6390]:oogenesis-enriched
    Interaction (215)
    WBProcess: WBbiopr:00000073
  Map_info: Map: V Position: 7.97972 Error: 0.013538
    Positive: Positive_clone: KB#6A2A
        T06E6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4246
        5380
    Pseudo_map_position
  Reference (47)
  Remark (4)
  Method: Gene