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WormBase Tree Display for Gene: WBGene00000591

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Name Class

WBGene00000591EvidenceCGC_data_submission
SMapS_parentSequenceK08A8
IdentityVersion1
NameCGC_namecoh-1
Sequence_nameK08A8.3
Molecular_name (12)
Other_namerad-21.2
CELE_K08A8.3Accession_evidenceNDBBX284606
Public_namecoh-1
DB_infoDatabaseAceViewgeneXI84
WormQTLgeneWBGene00000591
WormFluxgeneWBGene00000591
NDBlocus_tagCELE_K08A8.3
PanthergeneCAEEL|Gene_ORFName=CELE_K08A8.3|UniProtKB=A0A131MBD0
familyPTHR12585
NCBIgene181003
RefSeqproteinNM_001322622.4
NM_076861.8
NM_001322623.4
NM_001381024.1
TrEMBLUniProtAccA0A131MBB4
A0A131MBD0
A0A131MCR9
A0A131MBV3
UniProt_GCRPUniProtAccA0A131MBD0
OMIMgene606462
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcoh
Allele (159)
Legacy_information (3)
RNASeq_FPKM (74)
GO_annotation00001983
00001984
00001985
00001986
00001991
00001992
00107606
00107607
Ortholog (36)
ParalogWBGene00004737Caenorhabditis elegansFrom_analysisTreeFam
WormBase-Compara
Structured_descriptionConcise_descriptioncoh-1 encodes a RAD21 homolog that affects embryonic viability and is believed to affect cohesion of sister chromatids in somatic cells; expressed in the distal tip cells of the gonad, embryonic, and somatic cellsPaper_evidenceWBPaper00004722
Curator_confirmedWBPerson48
Date_last_updated09 Aug 2004 00:00:00
Automated_descriptionPredicted to enable chromatin binding activity. Predicted to be involved in replication-born double-strand break repair via sister chromatid exchange and sister chromatid cohesion. Predicted to be located in nucleus. Predicted to be part of cohesin complex. Expressed in several structures, including anterior distal tip cell; anterior gonad arm; germ line; and posterior distal tip cell. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; carcinoma (multiple); and endometrial cancer. Is an ortholog of human RAD21 (RAD21 cohesin complex component) and RAD21L1 (RAD21 cohesin complex component like 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0080508Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9811)
DOID:0050866Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9811)
DOID:3908Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9811)
DOID:0080199Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9811)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9811)
DOID:1380Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9811)
Molecular_infoCorresponding_CDSK08A8.3a
K08A8.3b
K08A8.3c
K08A8.3d
Corresponding_CDS_historyK08A8.3:wp252
Corresponding_transcriptK08A8.3a.1
K08A8.3b.1
K08A8.3c.1
K08A8.3d.1
Other_sequence (18)
Associated_featureWBsf670724
WBsf1005848
WBsf1005849
WBsf1005850
WBsf1005851
WBsf1005852
WBsf1023254
WBsf1023255
WBsf1023256
WBsf1023257
Experimental_infoRNAi_result (14)
Expr_patternExpr1349
Expr2580
Expr13113
Expr1026085
Expr1030346
Expr1153915
Expr2010297
Expr2028539
Drives_constructWBCnstr00037443
Construct_productWBCnstr00037443
AntibodyWBAntibody00000372
WBAntibody00000643
WBAntibody00000644
Microarray_results (26)
Expression_clusterWBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00040221:DAF-12_target_ALF4
WBPaper00044260:nicotic-acid_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Oogenic
WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00050094:glp-1(gf)_upregulated
WBPaper00050094:mes-2(bn11)_upregulated
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050412:cco-1(RNAi)_upregulated_N2
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:body-muscle_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051039:germline_enriched
WBPaper00051265:F4_hrde-1(tm1200)_upregulated
WBPaper00051265:F4_morc-1(tm6048)_upregulated
WBPaper00051305:vit-2(ac3)_downregulated
WBPaper00051352:Long-Term-Association-Memory_upregulated
WBPaper00052987:UV_upregulated_xpc-1;csb-1
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq
WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053599:female_vs_male_upregulated
WBPaper00053599:mitosis_vs_meiosis_downregulated
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055565:AVK_enriched
WBPaper00055648:germline_expressed
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056809:smn-1(ok355)_upregulated
WBPaper00056855:his-72(uge40)_upregulated
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061340:ABarpaaa_lineage
WBPaper00061340:Glia
WBPaper00061340:Neuroblast_IL1_IL2
WBPaper00061340:Parent_of_AMsh_URB
WBPaper00061340:Parent_of_hyp3_ILsoDx
WBPaper00061340:RME
WBPaper00061340:RMED
WBPaper00061340:RME_LR_parent
WBPaper00061340:URA_parent
WBPaper00061479:HDA-1_interacting_protein
WBPaper00061527:cids-2_2203-attf-2_2451
WBPaper00061527:tub-2_4713-daf-2_5288
WBPaper00062325:etr-1(lq61)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062498:PPM-1.D_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064130:Beta-Amyloid_downregulated_protein
WBPaper00064315:mes-3(bn199)_upregulated_EGCs
WBPaper00064315:mes-3(bn199)_upregulated_PGCs
WBPaper00064315:mes-4(bn73)_upregulated_EGCs
WBPaper00064315:mes-4(bn73)_upregulated_PGCs
WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
WBPaper00064716:paraquat_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065158:AFD_enriched
WBPaper00065975:P-body_vs_oocyte_enriched
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066093:E.coli-purE_downregulated
WBPaper00066110:Doxorubicin_downregulated_diploid
cgc4489_group_23
WBPaper00025141:unc-4::GFP_Enriched_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00030839:Embryo_A_Class
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031252:AIN-1_IP_enriched
WBPaper00032165:differentially_expressed_with_age_medoid_3
WBPaper00034661:AgNPs_downregulated
WBPaper00035905:FBF-1_Associated
WBPaper00036123:Cadmium_regulated
WBPaper00036286:Pattern_F
WBPaper00037611:GLD-2-associated
WBPaper00040963:TA100_down
WBPaper00040963:TA300_down
WBPaper00041174:genotypic
WBPaper00041174:genotypic_prime
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00045263:0.1mM-paraquat_upregulated
Interaction (81)
Map_infoMapXPosition-1.6802Error0.004761
PositivePositive_cloneK08A8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4486
5066
5498
Pseudo_map_position
ReferenceWBPaper00005937
WBPaper00012000
WBPaper00018377
WBPaper00026804
WBPaper00027033
WBPaper00031300
WBPaper00038491
WBPaper00055090
RemarkSequence connection from [Sugimoto A]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene