WormBase Tree Display for Gene: WBGene00004737
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| WBGene00004737 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F10G7 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | scc-1 | Person_evidence | WBPerson421 | |||||
| Sequence_name | F10G7.4 | ||||||||
| Molecular_name | F10G7.4 | ||||||||
| F10G7.4.1 | |||||||||
| CE02628 | |||||||||
| Other_name | coh-2 | Person_evidence | WBPerson421 | ||||||
| WBPerson1819 | |||||||||
| rad-21.1 | |||||||||
| CELE_F10G7.4 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | scc-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | scc | ||||||||
| Allele (26) | |||||||||
| Legacy_information | [J. Loidl] RNAi phenotypes : ~98% embryo lethality, HIM (~3% males); protein localizes to somatic nuclei of the embryo and to nuclei at meiotic prophase | ||||||||
| [J. Loidl] (F10G7.4) is homolog to the Rad21/Scc1/Rec8 family of cohesion proteins with knownmembers in S. cerevisiae, S. pombe, A. thaliana and vertebrates. R-S-R is the acronym of the founder family. | |||||||||
| Strain | WBStrain00035987 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00000591 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | scc-1 encodes a member of the Rad21/Rec8-like family of cohesion proteins that affects embryonic viability, fertility, the rate of embryonic cell divisions and the incidence of male progeny; interacts with ATL-1, F56D12.5, and F11E6.1 based on yeast two-hybrid assays, and is expressed in nondividing embryonic and germline nuclei. | Paper_evidence | WBPaper00004651 | |||||
| WBPaper00004722 | |||||||||
| WBPaper00005039 | |||||||||
| WBPaper00018377 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable chromatin binding activity and damaged DNA binding activity. Involved in meiotic cell cycle. Located in nucleus. Part of cohesin complex. Expressed in several structures, including SDQ; germ line; seam cell; touch receptor neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; carcinoma (multiple); and endometrial cancer. Is an ortholog of human RAD21 (RAD21 cohesin complex component) and RAD21L1 (RAD21 cohesin complex component like 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080508 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||
| DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||||
| DOID:0080199 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||||
| DOID:1380 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||||
| Molecular_info | Corresponding_CDS | F10G7.4 | |||||||
| Corresponding_transcript | F10G7.4.1 | ||||||||
| Other_sequence | CRC06495_1 | ||||||||
| MP00107 | |||||||||
| BXC03089_1 | |||||||||
| CBC02363_1 | |||||||||
| MI06164 | |||||||||
| CJC04977_1 | |||||||||
| CR03754 | |||||||||
| RSC00091_1 | |||||||||
| CJC01832_1 | |||||||||
| MIC05797_1 | |||||||||
| Associated_feature | WBsf644122 | ||||||||
| WBsf987674 | |||||||||
| WBsf221156 | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Expr1350 | ||||||||
| Expr2579 | |||||||||
| Expr11962 | |||||||||
| Expr1015315 | |||||||||
| Expr1032337 | |||||||||
| Expr1148255 | |||||||||
| Expr2015621 | |||||||||
| Expr2033856 | |||||||||
| Drives_construct | WBCnstr00035420 | ||||||||
| Construct_product | WBCnstr00035420 | ||||||||
| Antibody | WBAntibody00000375 | ||||||||
| WBAntibody00000636 | |||||||||
| WBAntibody00000645 | |||||||||
| WBAntibody00000646 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (151) | |||||||||
| Interaction (107) | |||||||||
| WBProcess | WBbiopr:00000099 | ||||||||
| Map_info | Map | II | Position | -3.59162 | Error | 0.111344 | |||
| Positive | Positive_clone | F10G7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4996 | |||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Sequence connection from [Sugimoto A] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
