WormBase Tree Display for Gene: WBGene00000591
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| WBGene00000591 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K08A8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | coh-1 | |||||||
| Sequence_name | K08A8.3 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | rad-21.2 | ||||||||
| CELE_K08A8.3 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | coh-1 | ||||||||
| DB_info | Database | AceView | gene | XI84 | |||||
| WormQTL | gene | WBGene00000591 | |||||||
| WormFlux | gene | WBGene00000591 | |||||||
| NDB | locus_tag | CELE_K08A8.3 | |||||||
| Panther | gene | CAEEL|Gene_ORFName=CELE_K08A8.3|UniProtKB=A0A131MBD0 | |||||||
| family | PTHR12585 | ||||||||
| NCBI | gene | 181003 | |||||||
| RefSeq | protein | NM_001322622.4 | |||||||
| NM_076861.8 | |||||||||
| NM_001322623.4 | |||||||||
| NM_001381024.1 | |||||||||
| TrEMBL | UniProtAcc | A0A131MBB4 | |||||||
| A0A131MBD0 | |||||||||
| A0A131MCR9 | |||||||||
| A0A131MBV3 | |||||||||
| UniProt_GCRP | UniProtAcc | A0A131MBD0 | |||||||
| OMIM | gene | 606462 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | coh | ||||||||
| Allele (159) | |||||||||
| Legacy_information | Paralogue of S.pombe rad21 | ||||||||
| [J. Loidl] RNAi phenotypes\: ~80% embryo lethality, HIM (~2% males); protein localizes to somatic nuclei of the embryo and the distal tip cell of the gonad | |||||||||
| (K08A8.3) is homolog to the Rad21/Scc1/Rec8 family of cohesion proteins with known members in S. cerevisiae, S. pombe, A. thaliana and vertebrates. R-S-R is the acronym of the founder family | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00001983 | ||||||||
| 00001984 | |||||||||
| 00001985 | |||||||||
| 00001986 | |||||||||
| 00001991 | |||||||||
| 00001992 | |||||||||
| 00107606 | |||||||||
| 00107607 | |||||||||
| Ortholog (36) | |||||||||
| Paralog | WBGene00004737 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | coh-1 encodes a RAD21 homolog that affects embryonic viability and is believed to affect cohesion of sister chromatids in somatic cells; expressed in the distal tip cells of the gonad, embryonic, and somatic cells | Paper_evidence | WBPaper00004722 | |||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 09 Aug 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable chromatin binding activity. Predicted to be involved in replication-born double-strand break repair via sister chromatid exchange and sister chromatid cohesion. Predicted to be located in nucleus. Predicted to be part of cohesin complex. Expressed in several structures, including anterior distal tip cell; anterior gonad arm; germ line; and posterior distal tip cell. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; carcinoma (multiple); and endometrial cancer. Is an ortholog of human RAD21 (RAD21 cohesin complex component) and RAD21L1 (RAD21 cohesin complex component like 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080508 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||
| DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||||
| DOID:0080199 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||||
| DOID:1380 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||||
| Molecular_info | Corresponding_CDS | K08A8.3a | |||||||
| K08A8.3b | |||||||||
| K08A8.3c | |||||||||
| K08A8.3d | |||||||||
| Corresponding_CDS_history | K08A8.3:wp252 | ||||||||
| Corresponding_transcript | K08A8.3a.1 | ||||||||
| K08A8.3b.1 | |||||||||
| K08A8.3c.1 | |||||||||
| K08A8.3d.1 | |||||||||
| Other_sequence (18) | |||||||||
| Associated_feature | WBsf670724 | ||||||||
| WBsf1005848 | |||||||||
| WBsf1005849 | |||||||||
| WBsf1005850 | |||||||||
| WBsf1005851 | |||||||||
| WBsf1005852 | |||||||||
| WBsf1023254 | |||||||||
| WBsf1023255 | |||||||||
| WBsf1023256 | |||||||||
| WBsf1023257 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr1349 | ||||||||
| Expr2580 | |||||||||
| Expr13113 | |||||||||
| Expr1026085 | |||||||||
| Expr1030346 | |||||||||
| Expr1153915 | |||||||||
| Expr2010297 | |||||||||
| Expr2028539 | |||||||||
| Drives_construct | WBCnstr00037443 | ||||||||
| Construct_product | WBCnstr00037443 | ||||||||
| Antibody | WBAntibody00000372 | ||||||||
| WBAntibody00000643 | |||||||||
| WBAntibody00000644 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (120) | |||||||||
| Interaction (81) | |||||||||
| Map_info | Map | X | Position | -1.6802 | Error | 0.004761 | |||
| Positive | Positive_clone | K08A8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4486 | |||||||
| 5066 | |||||||||
| 5498 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005937 | ||||||||
| WBPaper00012000 | |||||||||
| WBPaper00018377 | |||||||||
| WBPaper00026804 | |||||||||
| WBPaper00027033 | |||||||||
| WBPaper00031300 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Sequence connection from [Sugimoto A] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
