| WBGene00000411 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | R06F6 |
| Identity | Version | 1 |
| | Name | CGC_name | cdl-1 | Person_evidence | WBPerson634 |
| | | Sequence_name | R06F6.1 |
| | | Molecular_name (3) |
| | | Other_name | hbp |
| | | | CELE_R06F6.1 | Accession_evidence | NDB | BX284602 |
| | | Public_name | cdl-1 |
| | DB_info | Database | AceView | gene | 2L75 |
| | | | WormQTL | gene | WBGene00000411 |
| | | | WormFlux | gene | WBGene00000411 |
| | | | NDB | locus_tag | CELE_R06F6.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00000411|UniProtKB=Q09599 |
| | | | | family | PTHR17408 |
| | | | NCBI | gene | 174659 |
| | | | RefSeq | protein | NM_063919.8 |
| | | | SwissProt | UniProtAcc | Q09599 |
| | | | TREEFAM | TREEFAM_ID | TF316521 |
| | | | UniProt_GCRP | UniProtAcc | Q09599 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cdl |
| | Allele (37) |
| | Legacy_information | [A Sugimoto] Cell Death Lethal. w37: (null) zygotic lethal, embryonic arrest with accumulated cell corpses, body elongation defect, pharynx not connected to buccal cavity. e2501, e2510: (possibly neomorphs) similar to w37, but more severe corpse accumulation and elongation defect. |
| | Strain | WBStrain00022736 |
| | | WBStrain00033878 |
| | | WBStrain00036242 |
| | RNASeq_FPKM (74) |
| | GO_annotation (16) |
| | Ortholog (35) |
| | Structured_description | Concise_description | cdl-1 encodes a homolog of human hairpin (stem-loop) binding proteins (HBP/SLBP) that bind to the hairpin (stem-loop) structure in the 3' untranslated region (3' UTR) of histone mRNAs, and thus promote histone pre-mRNA processing and translation of mature histone mRNA; CDL-1 is required for normally high levels of histone gene expression, normal cell division during late larval development, embryonic viability, normal vulval morphogenesis, normally rapid apoptosis, and fertility; CDL-1 binds to the stem-loop structure in the 3' UTR of core-histone mRNA; the cdl-1 promoter is most active in dividing cells during embryogenesis and postembryonic development; both CDL-1 and human HBP contain a minimal RNA-binding domain (RBD) of roughly 73 amino acids that has no similarity with other known RNA-binding motifs. | Paper_evidence | WBPaper00004428 |
| | | | | | WBPaper00005085 |
| | | | | | WBPaper00005142 |
| | | | | | WBPaper00013577 |
| | | | | Person_evidence | WBPerson1874 |
| | | | | Curator_confirmed | WBPerson13481 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables mRNA 3'-UTR binding activity. Involved in apoptotic process; embryo development; and mitotic chromosome condensation. Predicted to be located in cytoplasm. Predicted to be part of histone pre-mRNA 3'end processing complex. Expressed widely. Is an ortholog of human SLBP (stem-loop histone mRNA binding protein). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | R06F6.1 |
| | Corresponding_CDS_history | R06F6.1:wp252 |
| | Corresponding_transcript | R06F6.1.1 |
| | Other_sequence (18) |
| | Associated_feature (12) |
| Experimental_info | RNAi_result | WBRNAi00082051 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00069364 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00009038 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00008237 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00034665 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00051393 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00026046 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00069365 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00082056 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00086822 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1840 |
| | | Expr10540 |
| | | Expr1028207 |
| | | Expr1030228 |
| | | Expr1155082 |
| | | Expr2009819 |
| | | Expr2028060 |
| | Drives_construct | WBCnstr00010480 |
| | | WBCnstr00015525 |
| | | WBCnstr00037562 |
| | Construct_product | WBCnstr00015525 |
| | | WBCnstr00037562 |
| | Microarray_results (21) |
| | Expression_cluster | WBPaper00028451:Oogenic_protein |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00035211:age-1_vs_age-1_downregulated |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038168:lin-35_downregulated |
| | | WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045618:puf-8_downregulated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00046509:lin-35(n745)_upregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049905:Age_variant_expression |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050193:cec-4(ok3124)_downregulated_L1 |
| | | WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050801:DAF-16_dauer_regulome |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F1_morc-1(tm6048)_downregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00054191:H3.3(null)_L1_upregulated |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:WDR-5.1_interacting_protein |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059174:PGL-1_interacting |
| | | WBPaper00059254:CSR-1_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060908:TEBP-1_interacting |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061340:ABarpaaa_lineage |
| | | WBPaper00061340:ADA_ADE_grandparent |
| | | WBPaper00061340:Body_wall_muscle |
| | | WBPaper00061340:Ciliated_amphid_neuron |
| | | WBPaper00061340:Ciliated_non_amphid_neuron |
| | | WBPaper00061340:Excretory_cell_parent |
| | | WBPaper00061340:g2_parent |
| | | WBPaper00061340:GLR |
| | | WBPaper00061340:I1_parent |
| | | WBPaper00061340:I2_grandparent |
| | | WBPaper00061340:M1_parent |
| | | WBPaper00061340:M4_parent |
| | | WBPaper00061340:Neuroblast_ADF_AWB |
| | | WBPaper00061340:Neuroblast_AIZ_FLP_RMG |
| | | WBPaper00061340:Neuroblast_ASE_ASJ_AUA |
| | | WBPaper00061340:Neuroblast_AVG_RIR |
| | | WBPaper00061340:Neuroblast_I6_M5 |
| | | WBPaper00061340:Neuroblast_IL1_IL2 |
| | | WBPaper00061340:Neuroblast_M2_M3 |
| | | WBPaper00061340:OLQ_grandparent |
| | | WBPaper00061340:Parent_of_hyp3_ILsoDx |
| | | WBPaper00061340:Parent_of_MI_pm1DR |
| | | WBPaper00061340:Parent_of_PVP_and_rect_V |
| | | WBPaper00061340:Pharyngeal_intestinal_valve |
| | | WBPaper00061340:Pharyngeal_neuron |
| | | WBPaper00061340:PLM_ALN_grandparent |
| | | WBPaper00061340:PLM_ALN_great_grandparent |
| | | WBPaper00061340:URA_parent |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:pcn-1-cyb-3_17196 |
| | | WBPaper00061699:daf-18(ok480)_upregulated |
| | | WBPaper00061753:csr-1(tor159)_downregulated_25C |
| | | WBPaper00062056:lin-35(n745)_upregulated |
| | | WBPaper00062056:lin-36(we36)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062456:doxycycline_downregulated_CB4856_protein |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062590:Aging_upregulated_neuron |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064505:tamoxifen_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_Ref |
| | | WBPaper00065841:1_0 |
| | | WBPaper00065841:1_2 |
| | | WBPaper00065841:3_0 |
| | | WBPaper00065841:11_0 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_6_3 |
| | | cgc4489_group_2 |
| | | WBPaper00005124:cholesterol_10-9M_regulated |
| | | WBPaper00005124:estrogen_10-5M_regulated |
| | | WBPaper00025032:cluster_22 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026952:class_A |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00037695:CC_3-day |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00039866:ClassComp_daf-19_upregulated |
| | | WBPaper00040426:CYD-1_CDK-4_upregulated |
| | | WBPaper00040426:CYE-1_CDK-2AF_upregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00048624:hlh-25(ok1710)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:cluster_2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (122) |
| | WBProcess | WBbiopr:00000014 |
| | | WBbiopr:00000015 |
| | | WBbiopr:00000036 |
| | | WBbiopr:00000098 |
| Map_info | Map | II | Position | 3.12577 | Error | 0.000223 |
| | Well_ordered |
| | Positive | Positive_clone | R06F6 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | T19E10 | Person_evidence | WBPerson634 |
| | Mapping_data | Multi_point | 4880 |
| | | Pos_neg_data | 10583 |
| | | | 10584 |
| | | | 10585 |
| | | | 10586 |
| Reference (22) |
| Method | Gene |
