WormBase Tree Display for Gene: WBGene00000239

WBGene00000239 SMap: S_parent: Sequence: C05D2
  Identity: Version: 1
    Name: CGC_name: bas-1 Person_evidence: WBPerson384
      Sequence_name: C05D2.4
      Molecular_name: C05D2.4a
        C05D2.4a.1
        CE01141
        C05D2.4b
        CE37081
        C05D2.4b.1
      Other_name: CELE_C05D2.4 Accession_evidence: NDB BX284603
      Public_name: bas-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: bas
    Allele (42)
    Legacy_information: [C.elegansII] ad446 : serotonin-deficient (nodetectable serotonin immunoreactivity);serotonin immunoreactivity restored by exposure to serotonin, but not to 5-hydroxytryptophan; poor male turning behavior [Loer and Kenyon 1993; LC; DA]
    Strain: WBStrain00024110
      WBStrain00027310
      WBStrain00027351
      WBStrain00055166
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog (44)
    Paralog (9)
    Structured_description: Concise_description: bas-1 encodes a serotonin- and dopamine-synthetic aromatic amino acid decarboxylase (AAADC) that is required for the synthesis of serotonin from 5-hydroxytryptophan in vivo; mutations of bas-1 impair the turning step in male mating, the migration of AVM, SDQR, ALM, and BDU neurons during development. Paper_evidence: WBPaper00005551
            WBPaper00024422
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 25 Aug 2010 00:00:00
      Automated_description: Predicted to enable L-dopa decarboxylase activity. Involved in several processes, including locomotion involved in locomotory behavior; phenol-containing compound biosynthetic process; and reproductive behavior. Predicted to be located in cytoplasm. Expressed in dopaminergic neurons; serotonergic neurons; socket cell; tail; and in male. Used to study cocaine abuse and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and hyperinsulinism. Is an ortholog of human DDC (dopa decarboxylase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:809 Homo sapiens Paper_evidence: WBPaper00034643
          Curator_confirmed: WBPerson324
          Date_last_updated: 28 May 2019 00:00:00
      DOID:0050742 Homo sapiens Paper_evidence: WBPaper00046053
          Curator_confirmed: WBPerson324
          Date_last_updated: 23 May 2019 00:00:00
    Potential_model: DOID:3312 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2719)
      DOID:0090123 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2719)
      DOID:14330 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2719)
      DOID:655 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2719)
      DOID:2018 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2719)
  Models_disease_asserted: WBDOannot00000678
    WBDOannot00000679
    WBDOannot00000680
  Molecular_info: Corresponding_CDS: C05D2.4a
      C05D2.4b
    Corresponding_CDS_history: C05D2.4:wp127
      C05D2.4:wp135
    Corresponding_transcript: C05D2.4a.1
      C05D2.4b.1
    Other_sequence (45)
    Associated_feature: WBsf047521
      WBsf047522
      WBsf645187
      WBsf654959
      WBsf992453
      WBsf992454
      WBsf224969
  Experimental_info: RNAi_result: WBRNAi00028502 Inferred_automatically: RNAi_primary
      WBRNAi00039751 Inferred_automatically: RNAi_primary
      WBRNAi00010206 Inferred_automatically: RNAi_primary
      WBRNAi00005935 Inferred_automatically: RNAi_primary
      WBRNAi00066618 Inferred_automatically: RNAi_primary
      WBRNAi00039752 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3088
      Expr11668
      Expr15319
      Expr16107
      Expr1021971
      Expr1030153
      Expr1143843
      Expr2009531
      Expr2027768
    Drives_construct: WBCnstr00005610
      WBCnstr00011126
      WBCnstr00019307
      WBCnstr00037638
      WBCnstr00042765
    Construct_product: WBCnstr00011126
      WBCnstr00019307
      WBCnstr00037638
      WBCnstr00040178
      WBCnstr00040179
    Microarray_results (25)
    Expression_cluster: WBPaper00031040:Cluster_1
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037946:LIN-39_interacting
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_CoreEnriched
      WBPaper00037950:dopaminergic-neurons_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_embryo_SelectivelyEnriched
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040990:PA14_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045390:tunicamycin_upregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00045974:NSM_enriched_totalRNA_tiling
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049626:UNC-75_target
      WBPaper00049905:Age_variant_expression
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056034:pals-25(jy9)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056731:human-amylin_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056855:his-72(uge40)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00059373:stt-3(RNAi)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059604:fluvastatin_upregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_upregulated_N2
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00059739:hira-1(gk835598)_downregulated_L4
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059895:wounding_downregulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:HB115_upregulated
      WBPaper00061106:endu-2(tm4977)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ADE
      WBPaper00061340:ADF
      WBPaper00061340:ASG
      WBPaper00061340:CEP
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:gst-26-pho-1_10767
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061651:HSN_enriched
      WBPaper00061651:NSM_enriched
      WBPaper00061651:PDE_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(syb385)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064532:pals-22(jy3)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00064952:Day10_vs_L4_downregulated_25C
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065623:113
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:17_0
      WBPaper00065841:30_5
      WBPaper00065841:36_0
      WBPaper00065841:36_2
      WBPaper00065841:36_3
      WBPaper00065841:116_0
      WBPaper00065841:145_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      cgc4386_cluster_3_4
      cgc4489_group_7
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00029437:rde-4_upregulated
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00034739:N2moreDR1350
      WBPaper00034757:down_by_oxidative_stress
      WBPaper00035873:dpy-10_regulated
      WBPaper00036286:Pattern_C
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037695:WC_5-day
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00040184:hcf-1down_sir-2.1down_daf-2nc
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040963:TA200_down
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00044535:male_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc6390]:Cluster_C
    Interaction (47)
  Map_info: Map: III Position: -1.46925 Error: 0.005315
    Well_ordered
    Positive: Positive_clone: C05D2 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 2312
        2693
        4332
  Reference (69)
  Method: Gene