| WBGene00003917 | SMap | S_parent | Sequence | F58B6 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | par-2 | Person_evidence | WBPerson314 |
| | | Sequence_name | F58B6.3 |
| | | Molecular_name (19) |
| | | Other_name | CELE_F58B6.3 | Accession_evidence | NDB | BX284603 |
| | | Public_name | par-2 |
| | DB_info | Database | AceView | gene | 3C183 |
| | | | WormQTL | gene | WBGene00003917 |
| | | | WormFlux | gene | WBGene00003917 |
| | | | NDB | locus_tag | CELE_F58B6.3 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00003917|UniProtKB=Q965F9 |
| | | | | family | PTHR44080 |
| | | | NCBI | gene | 175275 |
| | | | RefSeq | protein | NM_001420607.1 |
| | | | | | NM_001027459.7 |
| | | | | | NM_001420609.1 |
| | | | | | NM_001420606.1 |
| | | | | | NM_001381725.1 |
| | | | TrEMBL | UniProtAcc | A0A8S4SQT8 |
| | | | | | A0A8S4SL65 |
| | | | | | A0A8S4SK97 |
| | | | | | H1ZUX3 |
| | | | | | Q965F9 |
| | | | UniProt_GCRP | UniProtAcc | A0A8S4SQT8 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 02 Jan 2022 21:17:43 | WBPerson1983 | Event | Split_into | WBGene00306125 |
| | | Split_into | WBGene00306125 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | par |
| | Allele (329) |
| | Legacy_information | it46ts mat : homozygous hermaphrodites produce 90% (16x) to 99% (25x) arrested embryos escapers sterile; abnormal early cleavages defective P granule localization. ES3 (progeny). NA4 (it5ts : weaker phenotype e2030 : grandchildless). |
| | | See also e2030 |
| | | [C.elegansII] it46ts,mat : homozygous hermaphrodites produce 90% (16C) to 99% (25C) arrested embryos, escapers sterile; abnormal early cleavages, both spindles transverse at 2nd cleavage (failure of P1 rotation), defective P granule localization. ES3 (progeny). OA7: it5ts (weaker phenotype), e2030 (Mes, grandchildless),it87 (weak),jb2, etc. All ts; temp shift indicates not needed after 2nd cleavage. Cloned: encodes predicted novel protein. Antibody staining indicates specific asymmetric cortical localizations in early blastomeres. [Cheng et al. 1995; KK] |
| | Strain | WBStrain00022755 |
| | | WBStrain00023548 |
| | | WBStrain00023585 |
| | | WBStrain00023587 |
| | | WBStrain00026329 |
| | | WBStrain00026330 |
| | | WBStrain00026331 |
| | | WBStrain00035238 |
| | | WBStrain00036505 |
| | | WBStrain00036649 |
| | | WBStrain00000254 |
| | | WBStrain00000257 |
| | | WBStrain00007354 |
| | | WBStrain00007308 |
| | | WBStrain00007334 |
| | | WBStrain00024329 |
| | | WBStrain00054960 |
| | RNASeq_FPKM (74) |
| | GO_annotation (26) |
| | Contained_in_operon | CEOP3056 |
| | Ortholog (22) |
| | Structured_description | Concise_description | par-2 encodes a protein containing a C3HC4-type RING-finger, a specialized type of zinc-finger found in E3 ubiquitin ligase subunits; PAR-2 is required maternally for polarization of the C. elegans zygote along the anterior-posterior (A-P) axis and is asymmetrically localized to the posterior cortex of the one- and two-cell embryo via interdependent interactions with PAR-3, PAR-6, and PKC-3. | Paper_evidence | WBPaper00005115 |
| | | | | | WBPaper00005317 |
| | | | | | WBPaper00005405 |
| | | | | | WBPaper00005575 |
| | | | | | WBPaper00005735 |
| | | | | | WBPaper00005778 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables microtubule binding activity; phosphatidylinositol phosphate binding activity; and protein kinase binding activity. Involved in asymmetric cell division; asymmetric protein localization involved in cell fate determination; and establishment of mitotic spindle orientation. Located in P granule; posterior cell cortex; and protein-containing complex. Expressed in germ line. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F58B6.3a |
| | | F58B6.3b |
| | | F58B6.3c |
| | | F58B6.3d |
| | | F58B6.3e |
| | Corresponding_CDS_history | F58B6.3:wp19 |
| | | F58B6.3a:wp229 |
| | | F58B6.3a:wp283 |
| | | F58B6.3b:wp150 |
| | Corresponding_transcript | F58B6.3a.1 |
| | | F58B6.3b.1 |
| | | F58B6.3c.1 |
| | | F58B6.3d.1 |
| | | F58B6.3e.1 |
| | | F58B6.3e.2 |
| | | F58B6.3e.3 |
| | | F58B6.3e.4 |
| | | F58B6.3e.5 |
| | Other_sequence | CR05646 |
| | | CRC02017_1 |
| | | MPC00003_1 |
| | Associated_feature (14) |
| Experimental_info | RNAi_result (96) |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00009161 |
| | | WBCnstr00009162 |
| | | WBCnstr00009163 |
| | | WBCnstr00009164 |
| | | WBCnstr00009165 |
| | | WBCnstr00009166 |
| | | WBCnstr00009167 |
| | | WBCnstr00009168 |
| | | WBCnstr00009170 |
| | Construct_product (13) |
| | Antibody (11) |
| | Microarray_results (23) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032425:up_in_lin-35 |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00044316:CH3HgCl_7.5uM_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00045774:clk-1_downregulated_CoQ10_independent |
| | | WBPaper00046012:tdp-1(ok803)_downregulated |
| | | WBPaper00046509:lin-35(n745)_upregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:cco-1(RNAi)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00050182:lmn-1(L535P)_downregulated |
| | | WBPaper00050193:cec-4(ok3124)_downregulated_L1 |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061527:let-99_22121-B0238.9_11154 |
| | | WBPaper00061527:let-99_22239-such-1 |
| | | WBPaper00061527:ZK1053.4-C08F1.6 |
| | | WBPaper00061530:nhr-49(e2144)_downregulated |
| | | WBPaper00062056:lin-35(n745)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064107:lin-35(n745)_upregulated |
| | | WBPaper00064315:mes-3(bn199)_downregulated_EGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_6_4 |
| | | WBPaper00025032:cluster_8 |
| | | WBPaper00025032:cluster_35 |
| | | WBPaper00029437:dcr-1_downregulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040426:CYD-1_CDK-4_upregulated |
| | | WBPaper00040426:CYE-1_CDK-2AF_upregulated |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HQ_3d_2.0mM_Down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041906:I-3690_vs_OP50_3d |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_F |
| | Interaction (370) |
| | WBProcess | WBbiopr:00000017 |
| Map_info | Map | III | Position | -23.7021 | Error | 0.225136 |
| | Well_ordered |
| | Positive | Positive_clone | F58B6 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | Y11F11 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 2720 |
| | | | 2721 |
| | | | 4699 |
| | | Multi_point (11) |
| | Landmark_gene |
| Reference (312) |
| Method | Gene |
