| WBGene00015735 | SMap | S_parent | Sequence | C13B9 |
|---|
| Identity | Version | 3 |
| | Name | CGC_name | pdfr-1 | Paper_evidence | WBPaper00031656 |
| | | | | Person_evidence | WBPerson3516 |
| | | | | | WBPerson3480 |
| | | Sequence_name | C13B9.4 |
| | | Molecular_name (23) |
| | | Other_name | seb-1 | Person_evidence | WBPerson3006 |
| | | | | | WBPerson1263 |
| | | | CELE_C13B9.4 | Accession_evidence | NDB | BX284603 |
| | | Public_name | pdfr-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 18 Apr 2008 13:26:44 | WBPerson2970 | Name_change | CGC_name | pdfr-1 |
| | | | 3 | 29 Aug 2012 16:49:31 | WBPerson2970 | Name_change | Other_name | seb-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | pdfr |
| | Allele (246) |
| | Strain (11) |
| | RNASeq_FPKM (74) |
| | GO_annotation (31) |
| | Ortholog (47) |
| | Paralog | WBGene00007664 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00014035 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002251 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00002252 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00009304 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00017947 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00017948 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | pdfr-1 encodes, by alternative splicing, three isoforms of a G-protein-coupled receptor (GPCR) required for normal locomotion; PDFR-1 is orthologous to Drosophila pigment dispersing factor (PDF) receptors, and to human CALCR (OMIM:114131, associated with susceptibility to osteoporesis); pdfr-1 is expressed in all body wall muscles and many head and tail neurons; the C. elegans neuropeptides PDF-1a, PDF-1b, or PDF-2 (orthologous to Drosophila PDF) activated PDFR-1 receptors with dose-dependent nanomolar potency; in vivo, excess PDF-2 induces a movement phenotype like that seen in a pdf-1 null mutant, indicating that PDF-1a/b and PDF-2 exert opposite effects on PDFR-1. | Paper_evidence | WBPaper00012979 |
| | | | | | WBPaper00028902 |
| | | | | | WBPaper00031656 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 14 Jul 2008 00:00:00 |
| | | Automated_description | Enables calcitonin family receptor activity. Involved in several processes, including locomotory behavior; signal transduction; and sleep. Located in plasma membrane. Expressed in several structures, including I1 neuron; RMEV; ganglia; mechanosensory neurons; and vulD. Human ortholog(s) of this gene implicated in bone disease (multiple); hereditary lymphedema; and primary failure of tooth eruption. Is an ortholog of human CALCR (calcitonin receptor); CALCRL (calcitonin receptor like receptor); and PTH1R (parathyroid hormone 1 receptor). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0080020 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) |
| | | DOID:0050580 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16709) |
| | | DOID:0060387 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) |
| | | DOID:2256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) |
| | | DOID:0111341 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) |
| | | DOID:11476 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1440) |
| | | DOID:0111732 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) |
| Molecular_info | Corresponding_CDS | C13B9.4a |
| | | C13B9.4b |
| | | C13B9.4c |
| | | C13B9.4d |
| | | C13B9.4e |
| | Corresponding_CDS_history | C13B9.4:wp127 |
| | Corresponding_transcript (13) |
| | Other_sequence (25) |
| | Associated_feature (24) |
| Experimental_info | RNAi_result | WBRNAi00010677 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00005367 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027171 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00040427 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00024543 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00024544 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00028838 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (15) |
| | Drives_construct | WBCnstr00002179 |
| | | WBCnstr00002180 |
| | | WBCnstr00004248 |
| | | WBCnstr00004988 |
| | | WBCnstr00015834 |
| | | WBCnstr00015836 |
| | | WBCnstr00019100 |
| | | WBCnstr00021690 |
| | | WBCnstr00021702 |
| | | WBCnstr00028610 |
| | Construct_product (12) |
| | Antibody | WBAntibody00001399 |
| | Microarray_results (36) |
| | Expression_cluster | WBPaper00024970:GABAergic_neuron_specific |
| | | WBPaper00029359_1197 |
| | | WBPaper00029359_1225 |
| | | WBPaper00029359_1291 |
| | | WBPaper00029359_1367 |
| | | WBPaper00029359_1483 |
| | | WBPaper00029359_1494 |
| | | WBPaper00029359_1546 |
| | | WBPaper00029359_1561 |
| | | WBPaper00029359_1692 |
| | | WBPaper00032031:DConiospora_downregulated_OligoArray_24h |
| | | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_embryo_enriched |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045729:gld-2(RNAi)_upregulated |
| | | WBPaper00045809:rsd-2(yp10)_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set2 |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049098:heat-induced_hrde-1(tm1200) |
| | | WBPaper00049098:hrde-1(tm1200)-induced_23C |
| | | WBPaper00049098:hrde-1(tm1200)-induced_p15C |
| | | WBPaper00049098:hrde-1(tm1200)-repressed_23C |
| | | WBPaper00049098:hrde-1(tm1200)-repressed_p15C |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051265:F1_hrde-1(tm1200)_upregulated |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:alovudine_72h_regulated |
| | | WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053664:ins-11(tm1053)_upregulated |
| | | WBPaper00053810:clk-1(qm30)_upregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053810:isp-1(qm150)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055941:atfs-1(et15)_upregulated |
| | | WBPaper00055944:C.butyricum_vs_OP50_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056039:efa-6(tm3124)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056443:DietaryRestriction_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056855:his-72(uge40)_upregulated |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets |
| | | WBPaper00057162:meg-3_meg-4_downregulated_sRNA |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_upregulated |
| | | WBPaper00058948:npr-8(ok1439)_downregulated_OP50 |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:mut-16(pk710)_downregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIA |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:AUA |
| | | WBPaper00061340:DVC |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RID |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:SIB |
| | | WBPaper00061479:hda-1(ne4747)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:hrde-1(tm1200)_upregulated |
| | | WBPaper00061527:kin-29_2839-unc-9_3883 |
| | | WBPaper00061527:snt-4_17845-T27C4.1 |
| | | WBPaper00061651:AIM_enriched |
| | | WBPaper00061651:ASEL_enriched |
| | | WBPaper00061651:PHA_enriched |
| | | WBPaper00061651:RIB_enriched |
| | | WBPaper00061651:RIG_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00061995:mter-4(syb3662syb3403)_upregulated |
| | | WBPaper00062056:lin-15B(n744)_upregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-5(zr1234)_downregulated_germline |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062497:xpf-1(tm2842)_downregulated |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065392:Lb.delbrueckii_upregulated |
| | | WBPaper00065392:Lb.gasseri_upregulated |
| | | WBPaper00065392:Lb.plantarum_upregulated |
| | | WBPaper00065392:Lb.reuteri_upregulated |
| | | WBPaper00065392:P.pentosaceus_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:65_0 |
| | | WBPaper00065841:92_0 |
| | | WBPaper00065841:104_0 |
| | | WBPaper00065841:119_0 |
| | | WBPaper00065841:120_0 |
| | | WBPaper00065841:121_0 |
| | | WBPaper00065841:129_0 |
| | | WBPaper00065841:140_0 |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066085:sin-3(tm1276)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | WBPaper00066163:set-2(ok952)_upregulated_N2 |
| | | cgc4386_cluster_5_5 |
| | | cgc4489_group_19 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00029437:rde-1_upregulated |
| | | WBPaper00029437:rde-4_upregulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:osm-11_regulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00050407:hsp-6(RNAi)_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc6390]:Cluster_A |
| | | [cgc6390]:mixed_oogenesis-somatic |
| | Interaction (12) |
| Map_info | Map | III | Position | -1.02511 | Error | 0.00506 |
| | Positive | Positive_clone | C13B9 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00010230 |
| | WBPaper00012979 |
| | WBPaper00018302 |
| | WBPaper00019605 |
| | WBPaper00028902 |
| | WBPaper00031656 |
| | WBPaper00034125 |
| | WBPaper00035341 |
| | WBPaper00038491 |
| | WBPaper00039422 |
| | WBPaper00041096 |
| | WBPaper00041718 |
| | WBPaper00042479 |
| | WBPaper00043197 |
| | WBPaper00043343 |
| | WBPaper00043454 |
| | WBPaper00044094 |
| | WBPaper00047014 |
| | WBPaper00047452 |
| | WBPaper00047602 |
| | WBPaper00047901 |
| | WBPaper00051653 |
| | WBPaper00054889 |
| | WBPaper00055090 |
| | WBPaper00055514 |
| | WBPaper00057426 |
| | WBPaper00061844 |
| | WBPaper00062055 |
| | WBPaper00062132 |
| | WBPaper00062771 |
| | WBPaper00063630 |
| | WBPaper00063685 |
| | WBPaper00063827 |
| | WBPaper00063837 |
| | WBPaper00063859 |
| | WBPaper00065946 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
