| WBGene00006915 | SMap | S_parent | Sequence | CHROMOSOME_II |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | vha-6 |
| | | Sequence_name | VW02B12L.1 |
| | | Molecular_name | VW02B12L.1 |
| | | | VW02B12L.1.1 |
| | | | CE18980 |
| | | Other_name | CELE_VW02B12L.1 | Accession_evidence | NDB | BX284602 |
| | | Public_name | vha-6 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | vha |
| | Allele (54) |
| | Legacy_information | [Pujol N] vha-6 is expressed only in the intestine, from the embryonic coma stage through larvae and adult |
| | Strain | WBStrain00036524 |
| | RNASeq_FPKM (74) |
| | GO_annotation (17) |
| | Ortholog (58) |
| | Paralog | WBGene00006768 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006914 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006916 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | vha-6 encodes an ortholog of subunit a of the membrane-bound (V0) domainof vacuolar proton-translocating ATPase (V-ATPase); VHA-6 is orthologousto human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutatedin distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated inosteopetrosis); VHA-6 is expressed in germline (P2 through Z3 cellsuntil the comma stage), on the apical surface of postembryonicintestinal cells, and at the junction between pharynx and intestine;VHA-6 is required for growth and survival past the L1 larval stage;vha-6(RNAi) animals arrest as L1 larvae and remain alive (but do notgrow) for one week; in S. cerevisiae, different V0 a-subunits (Stv1p andVph1p) direct the assembly of V-ATPases to different membranes andorganelles, suggesting that the profusion of such subunits in C. elegans(co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have asimilar function; VHA-6 is predicted to capture protons from V-ATPasetransmembrane rotor components and export the protons across themembrane. | Paper_evidence | WBPaper00004601 |
| | | | | | WBPaper00004842 |
| | | | | | WBPaper00025183 |
| | | | | | WBPaper00028773 |
| | | | | | WBPaper00028774 |
| | | | | | WBPaper00028775 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 19 Nov 2006 00:00:00 |
| | | Automated_description | Predicted to enable ATPase binding activity. Involved in nematode larval development. Located in apical plasma membrane. Part of vacuolar proton-transporting V-type ATPase complex. Expressed in Psub2; excretory cell; hypodermis; pharyngeal-intestinal valve; and uterus. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and developmental and epileptic encephalopathy 104. Is an ortholog of several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0070390 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:865) |
| | | DOID:0110942 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11647) |
| | | DOID:14219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:866) |
| | | DOID:0112171 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18481) |
| | | EFO:MONDO:0015827 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:866) |
| | | DOID:0070134 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18481) |
| Molecular_info | Corresponding_CDS | VW02B12L.1 |
| | Corresponding_transcript | VW02B12L.1.1 |
| | Other_sequence (71) |
| | Associated_feature | WBsf650573 |
| | | WBsf650574 |
| | | WBsf989758 |
| | | WBsf1013237 |
| | | WBsf223933 |
| Experimental_info | RNAi_result (55) |
| | Expr_pattern | Expr851 |
| | | Expr2404 |
| | | Expr2407 |
| | | Expr13465 |
| | | Expr1029215 |
| | | Expr1032932 |
| | | Expr1158019 |
| | | Expr2017992 |
| | | Expr2036128 |
| | Drives_construct (205) |
| | Construct_product | WBCnstr00013297 |
| | | WBCnstr00016253 |
| | | WBCnstr00038389 |
| | Antibody | WBAntibody00000406 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032031:DConiospora_downregulated_cDNA_24h |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00033444:BacteriaDiet_regulated |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00037950:intestine_embryo_SelectivelyEnriched |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched |
| | | WBPaper00038168:lin-35_downregulated |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00044005:DAF-16_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_downregulated_HeatShock |
| | | WBPaper00045316:prg-1_upregulated_L1 |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045861:set-2(ok952)_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:lin-35(n745)_downregulated |
| | | WBPaper00048971:daf-16(mgDf50)_upregulated_L1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049368:daf-2(e1370)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049732:blmp-1(tm548);daf-7(e1372ts)_vs_daf-7(e1372ts)_upregulated |
| | | WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr) |
| | | WBPaper00049905:Age_variant_expression |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00049920:hyl-2(tm2031)_upregulated |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050094:mes-2(bn11)_upregulated |
| | | WBPaper00050094:mes-6(bn66)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051305:vit-2(ac3)_downregulated |
| | | WBPaper00051352:Long-Term-Association-Memory_downregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_upregulated |
| | | WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00053814:15C_downregulated_PY79 |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055827:daf-2(e1370)_downregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4 |
| | | WBPaper00056809:smn-1(ok355)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056855:his-72(uge40)_upregulated |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057068:ints-4(RNAi)_downregulated |
| | | WBPaper00057143:ztf-11(RNAi)_upregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058711:wdr-5(ok1417)_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_OP50 |
| | | WBPaper00059895:wounding_downregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_upregulated |
| | | WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27) |
| | | WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(overexpression)_downregulated |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_mRNA |
| | | WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640) |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061377:PAN-1_interacting |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061466:nath-10(icb102)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:C18B2.5-haf-4_181 |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062056:lin-36(we31)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_upregulated_N2_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064403:Heat-killed-E.Coli_upregulated |
| | | WBPaper00064637:cox-5B(RNAi)_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064871:hypoxia_upregulated_F1 |
| | | WBPaper00064992:Eugenol_downregulated |
| | | WBPaper00065086:JU1400_N.ausubeli_regulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065086:N2_N.ausubeli_regulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00065392:Lb.plantarum_upregulated |
| | | WBPaper00065392:Lb.reuteri_upregulated |
| | | WBPaper00065392:Lb.rhamnosus_upregulated |
| | | WBPaper00065392:P.pentosaceus_upregulated |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:3_0 |
| | | WBPaper00065841:3_1 |
| | | WBPaper00065841:3_2 |
| | | WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065984:pals-17(syb3980)_downregulated |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066085:hda-3(ok1991)_upregulated |
| | | cgc4386_cluster_1_3 |
| | | cgc4489_group_3 |
| | | WBPaper00005124:cholesterol_10-9M_regulated |
| | | WBPaper00005124:progesterone_10-7M_regulated |
| | | WBPaper00024393:strongly_regulated_dauer_genes |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_downregulated |
| | | WBPaper00025099:MA_specific |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00035479:daf-16(RNAi)_upregulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035892:Y.pestis_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00039851:Live_C_albicans_vs_HK_OP50 |
| | | WBPaper00040426:CYD-1_CDK-4_downregulated |
| | | WBPaper00040823:alg-1(gk214)_upregulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00044091:Bpseudomallei_repressed_4h |
| | | WBPaper00044091:Bpseudomallei_repressed_8h |
| | | WBPaper00044091:Bpseudomallei_repressed_12h |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | | WBPaper00049311:AgNO3_regulated |
| | | WBPaper00057098:SiO2-nanoparticles_downregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc5976]:class_2 |
| | | [cgc6390]:Cluster_C |
| | Interaction (123) |
| Map_info | Map | II | Position | 3.46558 | Error | 0.000297 |
| | Positive | Positive_clone | VW02B12L | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00004842 |
| | WBPaper00005295 |
| | WBPaper00005567 |
| | WBPaper00010347 |
| | WBPaper00029254 |
| | WBPaper00034480 |
| | WBPaper00035048 |
| | WBPaper00035182 |
| | WBPaper00036098 |
| | WBPaper00036578 |
| | WBPaper00036659 |
| | WBPaper00038491 |
| | WBPaper00046899 |
| | WBPaper00055090 |
| | WBPaper00057684 |
| | WBPaper00058161 |
| | WBPaper00058835 |
| | WBPaper00058870 |
| | WBPaper00059755 |
| | WBPaper00061730 |
| | WBPaper00062454 |
| | WBPaper00064023 |
| | WBPaper00064130 |
| | WBPaper00064187 |
| | WBPaper00064204 |
| | WBPaper00064229 |
| | WBPaper00064708 |
| | WBPaper00064933 |
| Remark | Sequence From: Pujol Nathalie via ACEDB feedback page <pujol@lgpd.univ-mrs.fr> |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
