| WBGene00019127 | SMap | S_parent | Sequence | F59G1 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | cgt-3 | Person_evidence | WBPerson365 |
| | | Sequence_name | F59G1.1 |
| | | Molecular_name (11) |
| | | Other_name | CELE_F59G1.1 | Accession_evidence | NDB | BX284602 |
| | | Public_name | cgt-3 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 17 Mar 2006 15:11:54 | WBPerson2970 | Name_change | CGC_name | cgt-3 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cgt |
| | Allele (90) |
| | Strain | WBStrain00037183 |
| | RNASeq_FPKM (74) |
| | GO_annotation (22) |
| | Contained_in_operon | CEOP2232 |
| | Ortholog (34) |
| | Paralog | WBGene00011517 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00011519 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00017625 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | cgt-3 encodes a transmembrane protein that is one of three C. elegans ceramide glucosyltransferases; by homology, CGT-3 is predicted to localize to the Golgi membrane and catalyze the transfer of glucose from UDP-glucose to ceramide to synthesize glucosylceramide, a glycosphingolipid precursor; although cgt-3 mutant worms show no obvious defects, animals doubly mutant for cgt-3 and cgt-1 arrest development in the early L1 larval stage, showing impaired feeding ability; in addition, cgt-3;cgt-1 and cgt-3;cgt-1;cgt-2 mutant animals show reduced glucosylceramide levels; a CGT-3::GFP reporter fusion is expressed in pharyngeal tissues, the intestine, the pharyngeal-intestinal and intestinal-rectal valves, the rectal gland cells, head mesodermal cells and additional unidentified head cells; cgt-3 expression in mouse GM95 cells, deficient in glucosylceramide due to a defect in glucosylceramide synthase, confirms that CGT-3 has ceramide glucosyltransferase activity. | Paper_evidence | WBPaper00032934 |
| | | | | | WBPaper00035299 |
| | | | | | WBPaper00035300 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 14 Oct 2009 00:00:00 |
| | | Automated_description | Predicted to enable ceramide glucosyltransferase activity. Involved in several processes, including glucosylceramide biosynthetic process; regulation of mesodermal cell fate specification; and regulation of protein localization to basolateral plasma membrane. Located in plasma membrane. Expressed in several structures, including germ line; pharyngeal muscle cell; pharyngeal-intestinal valve; rectal gland cell; and rectal valve cell. Is an ortholog of human UGCG (UDP-glucose ceramide glucosyltransferase). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F59G1.1a |
| | | F59G1.1b |
| | | F59G1.1d |
| | Corresponding_CDS_history | F59G1.1c:wp261 |
| | Corresponding_transcript | F59G1.1c |
| | | F59G1.1a.1 |
| | | F59G1.1b.1 |
| | | F59G1.1b.2 |
| | | F59G1.1d.1 |
| | Other_sequence | Dviv_isotig16419 |
| | | CR01538 |
| | | CBC08690_1 |
| | | CRC04587_1 |
| | | CBC03012_1 |
| | | Dviv_isotig16418 |
| | | PPC16435_1 |
| | Associated_feature | WBsf644243 |
| | | WBsf657640 |
| | | WBsf657641 |
| | | WBsf657642 |
| | | WBsf657643 |
| | | WBsf987995 |
| | | WBsf221361 |
| | | WBsf221362 |
| | | WBsf221363 |
| | | WBsf221364 |
| Experimental_info | RNAi_result | WBRNAi00078077 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00115313 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00078082 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00083996 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00088628 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00078081 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00016142 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00078080 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00049231 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00088735 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00033226 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00078078 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00078076 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00065438 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00049232 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00078079 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00083974 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00112310 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Chronogram1781 |
| | | Expr6269 |
| | | Expr8290 |
| | | Expr8572 |
| | | Expr11539 |
| | | Expr1013875 |
| | | Expr1038257 |
| | | Expr1152973 |
| | | Expr2009948 |
| | | Expr2028188 |
| | Drives_construct | WBCnstr00003401 |
| | | WBCnstr00013239 |
| | | WBCnstr00013370 |
| | | WBCnstr00019065 |
| | Construct_product | WBCnstr00013239 |
| | | WBCnstr00019065 |
| | Microarray_results (46) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040412:germline-regulated_daf-16_target |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00046509:lin-35(n745)_downregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053039:Aspirin_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053388:dauer_regulated_Cluster6 |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_upregulated |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00061340:Neuroblast_I6_M5 |
| | | WBPaper00061527:lst-4_22151-F46F11.6_12556 |
| | | WBPaper00061530:nhr-49(e2144)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062456:doxycycline_upregulated_CB4856_protein |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:25C_vs_15C_upregulated_AFD |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065258:anchor-cell_depleted |
| | | WBPaper00065841:9_0 |
| | | WBPaper00065841:9_1 |
| | | WBPaper00065841:15_0 |
| | | WBPaper00065841:24_1 |
| | | WBPaper00065841:27_0 |
| | | WBPaper00065841:30_4 |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065995:M.humicola-extract_upregulated_N2 |
| | | cgc4386_cluster_3_3 |
| | | cgc4489_group_4 |
| | | WBPaper00005124:progesterone_10-7M_regulated |
| | | WBPaper00025032:cluster_56 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00037147:heatshock_upregulated |
| | | WBPaper00037611:RNP-8-associated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040210:Chlorpyrifos_16C_regulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | [cgc5767]:cluster_1 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(41_min) |
| | | [cgc5767]:expression_class_MD_pd(53_min) |
| | | [cgc5767]:expression_class_SM |
| | | [cgc5767]:expression_class_SMD |
| | Interaction (17) |
| | WBProcess | WBbiopr:00000137 |
| Map_info | Map | II | Position | -0.853217 | Error | 0.000266 |
| | Positive | Positive_clone | F59G1 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (18) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
