| WBGene00017244 | SMap | S_parent | Sequence | F08C6 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | apy-1 | Paper_evidence | WBPaper00031456 |
| | | Sequence_name | F08C6.6 |
| | | Molecular_name | F08C6.6 |
| | | | F08C6.6.1 |
| | | | CE27925 |
| | | Other_name | CELE_F08C6.6 | Accession_evidence | NDB | BX284606 |
| | | Public_name | apy-1 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:30:58 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 07 Feb 2008 17:23:14 | WBPerson2970 | Name_change | CGC_name | apy-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | apy |
| | Allele (32) |
| | Strain | WBStrain00035260 |
| | | WBStrain00033129 |
| | RNASeq_FPKM (74) |
| | GO_annotation (36) |
| | Ortholog (36) |
| | Paralog | WBGene00044355 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | apy-1 encodes a membrane-bound uridine diphosphatase (UDPase, endo-apyrase) orthologous to human CANT1 and paralogous to ZK563.7; APY-1 is required for repression of the unfolded protein response of stressed endoplasmic reticulum (ER), for normally organized pharynx and thin muscle fibers in adults, and for normally high fertility, rapid growth, and long lifespan; apy-1 is transcriptionally activated by tunicamycin, 6% EtOH, or excess heat (25 degrees C), each of which stresses the ER, and this activation requires both ATF-6 and IRE-1; APY-1 can hydrolyze either UDP or GDP, but has more activity with UDP. | Paper_evidence | WBPaper00031456 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 16 Jul 2008 00:00:00 |
| | | Automated_description | Enables GDP phosphatase activity and UDP phosphatase activity. Involved in several processes, including determination of adult lifespan; endoplasmic reticulum unfolded protein response; and ribonucleoside diphosphate catabolic process. Located in membrane. Expressed in hypodermis and pharynx. Human ortholog(s) of this gene implicated in Desbuquois dysplasia and multiple epiphyseal dysplasia 7. Is an ortholog of human CANT1 (calcium activated nucleotidase 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0060462 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19721) |
| | | DOID:0070302 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19721) |
| Molecular_info | Corresponding_CDS | F08C6.6 |
| | Corresponding_transcript | F08C6.6.1 |
| | Other_sequence | GU936595.1 |
| | | FC545533.1 |
| | | MH00693 |
| | | CR01517 |
| | | Hbac_isotig01845 |
| | | Dviv_isotig28489 |
| | | FR671368.1 |
| | | Acan_isotig10353 |
| | | TSC13875_1 |
| | | DAC01442_1 |
| | | JI470741.1 |
| | | ES413581.1 |
| | | EX557552.1 |
| | | ES739525.1 |
| | | FC547570.1 |
| | | Dviv_isotig07282 |
| | | ACC17883_1 |
| | | Oden_isotig07723 |
| | | Dviv_isotig07281 |
| | | TDC00461_1 |
| | | JI226183.1 |
| | | FC545292.1 |
| | | CJC00253_1 |
| | | FC544308.1 |
| | | EX013152.1 |
| | | Dviv_isotig11732 |
| | | JI478065.1 |
| | | CJC00138_1 |
| | | Oden_isotig07724 |
| | | JI477882.1 |
| | | JI179930.1 |
| | | XIC01632_1 |
| | | CRC08817_1 |
| | | Oden_isotig07722 |
| | | EX911070.1 |
| | | EX566710.1 |
| | | BXC02248_1 |
| | | TMC01196_1 |
| | | FC553977.1 |
| | | ES743480.1 |
| | | ES414208.1 |
| | | HG00322 |
| | | Dviv_isotig24159 |
| | | XI00674 |
| | | Tcir_isotig13330 |
| | | PPC01556_1 |
| | | ES413926.1 |
| | | Oden_isotig07726 |
| | | EV850806.1 |
| | | CB039162.1 |
| | | Oden_isotig07725 |
| | | CR11254 |
| | | HBC04433_1 |
| | | ES561609.1 |
| | | EX012952.1 |
| | | DA00144 |
| | | PP02133 |
| | | Name_isotig04811 |
| | | EV851523.1 |
| | | BMC15633_1 |
| | | HG09909 |
| | | CBC02872_1 |
| | | EX552670.1 |
| | | ES412743.1 |
| | | Oden_isotig07721 |
| | | JI475523.1 |
| | | FC541769.1 |
| | | Tcir_isotig05355 |
| | | HGC08059_1 |
| | | TM01518 |
| | | DVC01568_1 |
| | | Acan_isotig18194 |
| | | Oden_isotig07727 |
| | | Oden_isotig07728 |
| | | ES408959.1 |
| | Associated_feature | WBsf670740 |
| | | WBsf670741 |
| | | WBsf982198 |
| | | WBsf237596 |
| Experimental_info | RNAi_result (15) |
| | Expr_pattern | Chronogram1929 |
| | | Expr7496 |
| | | Expr8181 |
| | | Expr1022911 |
| | | Expr1037405 |
| | | Expr1147956 |
| | | Expr2009375 |
| | | Expr2027611 |
| | Drives_construct | WBCnstr00000535 |
| | | WBCnstr00001058 |
| | | WBCnstr00012641 |
| | | WBCnstr00013164 |
| | | WBCnstr00027459 |
| | Construct_product | WBCnstr00027459 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00028451:Low_abundance_spermatogenesis_enriched |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00032976:non_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00033065:isp-1-1(qm150)_upregulated |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00037950:intestine_embryo_SelectivelyEnriched |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_embryo_enriched |
| | | WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038213:E.coli(LF82)_72h_upregulated |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00040560:hpl-2_embryo_downregulated |
| | | WBPaper00040965:lipid-droplet_associated_protein |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00046509:lin-35(n745)_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031) |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00049954:BPA_upregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050801:DAF-12_dauer_regulome |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051021:4-bromodiphenyl-ether_upregulated |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053810:isp-1(qm150)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055941:atfs-1(et15)_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056034:pals-25(jy9)_upregulated |
| | | WBPaper00056073:NHR-86_interacting_promoter |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056443:DietaryRestriction_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056809:smn-1(ok355)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058599:benzimidazoles_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_protein |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059604:fluvastatin_downregulated_dlk-1(km12) |
| | | WBPaper00059604:fluvastatin_downregulated_N2 |
| | | WBPaper00059816:crh-1(n3315)_downrgulated |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_OP50 |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00059895:wounding_downregulated |
| | | WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27) |
| | | WBPaper00060084:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060278:atp-2(RNAi)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061045:Y56A3A.22(cck200)_upregulated |
| | | WBPaper00061340:Intestine |
| | | WBPaper00061340:rect_D |
| | | WBPaper00061527:dhs-28_22199-acs-14 |
| | | WBPaper00061530:nhr-49(e2144)_downregulated |
| | | WBPaper00061590:CGP37157_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062456:doxycycline_upregulated_CB4856_protein |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062590:Aging_downregulated_hypodermis |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_downregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064291:antimycin_upregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064637:cox-5B(RNAi)_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064789:Day12_vs_Day1_downregulated_neuron |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065225:nhr-42(tm1375)_downregulated_S.aureus-infected |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4386_cluster_2_4 |
| | | cgc4489_group_3 |
| | | WBPaper00005124:cholesterol_10-9M_regulated |
| | | WBPaper00006465:II_ethanol_late_induction |
| | | WBPaper00025032:cluster_5 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026952:class_A |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00028483:Up_mes-4_vs_WT |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00032948:FedUp |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00038231:Cry5B_1.5-fold_downregulated |
| | | WBPaper00040210:Chlorpyrifos_16C_regulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041211:RPW-24_Up |
| | | WBPaper00041370:spg-7(RNAi)_upregulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00048624:hlh-25(ok1710)_upregulated |
| | | WBPaper00053236:daf-16(mgDF50)_regulated_Starved |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00055899:2,4-Dinitroanisole_regulated |
| | | WBPaper00055899:nitrotriazolone_regulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_downregulated |
| | | [cgc5767]:cluster_2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(83_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_C |
| | Interaction (39) |
| | WBProcess | WBbiopr:00000046 |
| | | WBbiopr:00000079 |
| Map_info | Map | X | Position | -1.52591 | Error | 0.009212 |
| | Positive | Positive_clone | F08C6 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00029024 |
| | WBPaper00031456 |
| | WBPaper00032062 |
| | WBPaper00038341 |
| | WBPaper00038491 |
| | WBPaper00055090 |
| | WBPaper00064934 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
