WormBase Tree Display for Gene: WBGene00015047

WBGene00015047 SMap: S_parent: Sequence: B0218
  Identity: Version: 3
    Name: CGC_name: faah-1 Person_evidence: WBPerson3660
            WBPerson3406
            WBPerson1799
      Sequence_name: B0218.1
      Molecular_name: B0218.1
        B0218.1.1
        CE06684
        B0218.1.2
        B0218.1.3
      Other_name: svh-3 Paper_evidence
          Person_evidence: WBPerson1068
            WBPerson1315
        CELE_B0218.1 Accession_evidence: NDB BX284604
      Public_name: faah-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:55 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 21 Apr 2009 16:04:55 WBPerson9133 Name_change: CGC_name: faah-1
        3 04 Apr 2017 12:10:45 WBPerson2970 Name_change: Other_name: svh-3
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: faah
    Allele (37)
    RNASeq_FPKM (74)
    GO_annotation: 00058193
      00058194
      00058195
      00058196
      00058197
      00058198
      00058199
      00058200
      00058201
      00058202
    Ortholog (43)
    Paralog: WBGene00012750 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013226 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013232 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00015048 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00019068 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013164 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021508 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: faah-1 encodes a putative fatty acid amide hydrolase enzyme and is orthologous to human fatty acid amide hydrolase (FAAH); faah-1 is involved in regulating N-acylethanolamines (NAEs), which are lipid-derived signalling molecules, reduced levels of which, under dietary restriction, result in increased lifespan; faah-1 functions to hydrolyse N-acylethanolamines (NAEs) like eicosapentaenoyl ethanolamide (EPEA) and arachidonoyl ethanolamide (AEA), as worms overexpressing faah-1 had reduced levels of NAEs; faah-1 is also required for normal growth and development. Paper_evidence: WBPaper00041646
            WBPaper00038417
          Curator_confirmed: WBPerson324
          Date_last_updated: 02 Apr 2013 00:00:00
      Automated_description: Predicted to enable amidase activity and fatty acid amide hydrolase activity. Involved in positive regulation of axon regeneration. Expressed in pharyngeal neurons and pharynx. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Is an ortholog of human FAAH (fatty acid amide hydrolase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:303 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3553)
      DOID:9970 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3553)
  Molecular_info: Corresponding_CDS: B0218.1
    Corresponding_CDS_history: B0218.1b:wp261
    Corresponding_transcript: B0218.1.1
      B0218.1.2
      B0218.1.3
    Other_sequence: EX541954.1
      FG976494.1
      FG975185.1
      CBC01857_1
      Dviv_isotig11481
      EW741532.1
      CJC00010_1
      Oden_isotig19778
      FG971781.1
      FC542292.1
      FF680006.1
      Oden_isotig11879
      ACC23342_1
      FG971176.1
      FK805862.1
      Acan_isotig10003
      EX535759.1
      FF680492.1
      Tcir_isotig06550
      EY470753.1
      FK803167.1
      FG980538.1
      FF678892.1
      Tcir_isotig07541
      AE04371
      CBC14338_1
      ACC01697_1
      Dviv_isotig11482
      FG974222.1
      Oden_isotig11881
      FG976291.1
      JO469876.1
      Acan_isotig08869
      AE03288
      Oden_isotig11880
      FG975326.1
      AYC01646_1
      FK808045.1
      Dviv_isotig11483
      Dviv_isotig11480
      JI166450.1
      FF680309.1
      EY462486.1
      EX558573.1
    Associated_feature: WBsf228636
      WBsf228637
      WBsf228638
  Experimental_info: RNAi_result: WBRNAi00027997 Inferred_automatically: RNAi_primary
      WBRNAi00009591 Inferred_automatically: RNAi_primary
      WBRNAi00001800 Inferred_automatically: RNAi_primary
      WBRNAi00038743 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9301
      Expr10655
      Expr13911
      Expr1021051
      Expr1036428
      Expr1142954
      Expr2011412
      Expr2029648
    Drives_construct: WBCnstr00008603
      WBCnstr00013885
      WBCnstr00017426
      WBCnstr00029130
    Construct_product: WBCnstr00008294
      WBCnstr00008295
      WBCnstr00008604
      WBCnstr00008605
      WBCnstr00008606
      WBCnstr00029130
    Microarray_results (30)
    Expression_cluster: WBPaper00005700:transmembrane_protein
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032425:down_in_zfp-1
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033065:isp-1-1(qm150)_upregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040990:PA14_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049920:hyl-2(tm2031)_upregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_upregulated_24-cell-embryo
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051265:F1_morc-1(tm6048)_upregulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055648:male-tail_expressed
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056619:CEPsh_enriched
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057143:ztf-11(RNAi)_upregulated
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060951:mrpl-2(osa3)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061340:F_U
      WBPaper00061340:Rectal_gland
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:gtl-1-hum-8_16432
      WBPaper00061651:Rectal_gland_enriched
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_downregulated_protein
      WBPaper00064716:paraquat_downregulated
      WBPaper00064735:bet-1(uth41)_vs_N2_upregulated
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065841:9_0
      WBPaper00065841:9_1
      WBPaper00065841:9_2
      WBPaper00065841:15_0
      WBPaper00065841:21_0
      WBPaper00065841:24_0
      WBPaper00065841:24_1
      WBPaper00065841:26_0
      WBPaper00065841:26_1
      WBPaper00065841:26_2
      WBPaper00065841:27_0
      WBPaper00065841:30_0
      WBPaper00065841:30_3
      WBPaper00065841:30_4
      WBPaper00065841:79_0
      WBPaper00065841:79_2
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4489_group_11
      WBPaper00025032:cluster_61
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00032062:age_regulated_genes
      WBPaper00034739:N2moreDR1350
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00035892:KIM5_vs_OP50_Up
      WBPaper00035892:Y.pestis_regulated
      WBPaper00036286:Pattern_I
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040963:TA100_up
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053688:E.faecalis_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(66_min)
      [cgc5767]:expression_class_E_pi(66_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
    Interaction (120)
  Map_info: Map: IV Position: 3.64664 Error: 0.000578
    Positive: Positive_clone: B0218 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00041646
    WBPaper00043050
    WBPaper00043348
    WBPaper00046049
    WBPaper00047621
    WBPaper00055090
    WBPaper00060352
    WBPaper00065026
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene