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WormBase Tree Display for Gene: WBGene00006915

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Name Class

WBGene00006915SMapS_parentSequenceCHROMOSOME_II
IdentityVersion1
NameCGC_namevha-6
Sequence_nameVW02B12L.1
Molecular_nameVW02B12L.1
VW02B12L.1.1
CE18980
Other_nameCELE_VW02B12L.1Accession_evidenceNDBBX284602
Public_namevha-6
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classvha
Allele (54)
Legacy_information[Pujol N] vha-6 is expressed only in the intestine, from the embryonic coma stage through larvae and adult
StrainWBStrain00036524
RNASeq_FPKM (74)
GO_annotation (17)
Ortholog (58)
ParalogWBGene00006768Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006914Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006916Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionvha-6 encodes an ortholog of subunit a of the membrane-bound (V0) domainof vacuolar proton-translocating ATPase (V-ATPase); VHA-6 is orthologousto human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutatedin distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated inosteopetrosis); VHA-6 is expressed in germline (P2 through Z3 cellsuntil the comma stage), on the apical surface of postembryonicintestinal cells, and at the junction between pharynx and intestine;VHA-6 is required for growth and survival past the L1 larval stage;vha-6(RNAi) animals arrest as L1 larvae and remain alive (but do notgrow) for one week; in S. cerevisiae, different V0 a-subunits (Stv1p andVph1p) direct the assembly of V-ATPases to different membranes andorganelles, suggesting that the profusion of such subunits in C. elegans(co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have asimilar function; VHA-6 is predicted to capture protons from V-ATPasetransmembrane rotor components and export the protons across themembrane.Paper_evidenceWBPaper00004601
WBPaper00004842
WBPaper00025183
WBPaper00028773
WBPaper00028774
WBPaper00028775
Curator_confirmedWBPerson567
Date_last_updated19 Nov 2006 00:00:00
Automated_descriptionPredicted to enable ATPase binding activity. Involved in nematode larval development. Located in apical plasma membrane. Part of vacuolar proton-transporting V-type ATPase complex. Expressed in Psub2; excretory cell; hypodermis; pharyngeal-intestinal valve; and uterus. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and developmental and epileptic encephalopathy 104. Is an ortholog of several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0070390Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:865)
DOID:0110942Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11647)
DOID:14219Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:866)
DOID:0112171Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:18481)
EFO:MONDO:0015827Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:866)
DOID:0070134Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:18481)
Molecular_infoCorresponding_CDSVW02B12L.1
Corresponding_transcriptVW02B12L.1.1
Other_sequenceAB055111
EX008139.1
FN601335.1
Oden_isotig12989
AS05322
FD513973.1
EX558568.1
PPC02052_1
Tcir_isotig07492
ACC04350_1
Tcir_isotig29012
Dviv_isotig35691
SR02674
FG973358.1
Name_isotig03156
MJ04859
FC543463.1
Dviv_isotig28706
EX012282.1
FC541220.1
PTC01014_1
CJC00902_1
EX008515.1
JO472469.1
ES561315.1
NAC00347_1
SRC01652_1
Tcir_isotig16492
HBC21651_1
FC543579.1
Tcol_isotig13075
FC543557.1
Acan_isotig18969
EY465731.1
BG467540.1
ASC01106_1
ASC24020_1
Hbac_isotig03389
FC810282.1
Hbac_isotig06054
JI171090.1
JI220521.1
JI174902.1
EY469248.1
PPC17889_1
SRC01750_1
ACC12501_1
FC815931.1
ACC15048_1
Dviv_isotig26420
AS08080
FC815666.1
Acan_isotig07945
PT01196
HC00751
PPC13084_1
HCC04093_1
CBC03657_1
FC810508.1
HBC14954_1
FC541171.1
JO472504.1
Name_isotig06322
CSC00688_1
Oden_isotig26768
BU606334.1
Oden_isotig12990
AS01642
PP02479
FC540466.1
MJC03988_1
Associated_featureWBsf650573
WBsf650574
WBsf989758
WBsf1013237
WBsf223933
Experimental_infoRNAi_result (55)
Expr_patternExpr851
Expr2404
Expr2407
Expr13465
Expr1029215
Expr1032932
Expr1158019
Expr2017992
Expr2036128
Drives_construct (205)
Construct_productWBCnstr00013297
WBCnstr00016253
WBCnstr00038389
AntibodyWBAntibody00000406
Microarray_results (20)
Expression_clusterWBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032031:DConiospora_downregulated_cDNA_24h
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00033444:BacteriaDiet_regulated
WBPaper00035073:mitochondria_protein
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:intestine_embryo_enriched
WBPaper00037950:intestine_embryo_SelectivelyEnriched
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_larva_enriched
WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched
WBPaper00038168:lin-35_downregulated
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00044005:DAF-16_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00044746:aging_downregulated_HeatShock
WBPaper00045316:prg-1_upregulated_L1
WBPaper00045521:Gender_Neutral
WBPaper00045861:set-2(ok952)_upregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00046509:lin-35(n745)_downregulated
WBPaper00048971:daf-16(mgDf50)_upregulated_L1
WBPaper00048988:neuron_expressed
WBPaper00049368:daf-2(e1370)_downregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049732:blmp-1(tm548);daf-7(e1372ts)_vs_daf-7(e1372ts)_upregulated
WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
WBPaper00049905:Age_variant_expression
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049920:hyl-2(tm2031)_upregulated
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050094:mes-2(bn11)_upregulated
WBPaper00050094:mes-6(bn66)_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:intestine_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
WBPaper00051305:vit-2(ac3)_downregulated
WBPaper00051352:Long-Term-Association-Memory_downregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053599:female_vs_male_downregulated
WBPaper00053599:oocyte_vs_mitosis_upregulated
WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00053814:15C_downregulated_PY79
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055827:daf-2(e1370)_downregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055971:nhl-2(ok818)_20C_downregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00056826:hmc_biased
WBPaper00056855:his-72(uge40)_upregulated
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057068:ints-4(RNAi)_downregulated
WBPaper00057143:ztf-11(RNAi)_upregulated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058711:wdr-5(ok1417)_downregulated
WBPaper00058725:sftb-1(cer6)_downregulated
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059895:wounding_downregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060014:set-2(zr2012)_upregulated
WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(overexpression)_downregulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061377:PAN-1_interacting
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061466:nath-10(icb102)_upregulated
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:C18B2.5-haf-4_181
WBPaper00061818:ELKS-1_interacting
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062056:lin-36(we31)_upregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062590:Aging_downregulated_neuron
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064005:starvation_upregulated_N2_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064122:vulva_transcriptome
WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
WBPaper00064403:Heat-killed-E.Coli_upregulated
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064871:hypoxia_upregulated_F1
WBPaper00064992:Eugenol_downregulated
WBPaper00065086:JU1400_N.ausubeli_regulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065086:N2_N.ausubeli_regulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065149:lin-52(n771)_downregulated
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_downregulated_cisplatin
WBPaper00065373:sek-1(km4)_downregulated_Ref
WBPaper00065392:Lb.plantarum_upregulated
WBPaper00065392:Lb.reuteri_upregulated
WBPaper00065392:Lb.rhamnosus_upregulated
WBPaper00065392:P.pentosaceus_upregulated
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:3_0
WBPaper00065841:3_1
WBPaper00065841:3_2
WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065984:pals-17(syb3980)_downregulated
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066085:hda-3(ok1991)_upregulated
cgc4386_cluster_1_3
cgc4489_group_3
WBPaper00005124:cholesterol_10-9M_regulated
WBPaper00005124:progesterone_10-7M_regulated
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
WBPaper00025099:MA_specific
WBPaper00025141:N2_Expressed_Genes
WBPaper00026980:intestine_enriched
WBPaper00030985:Enterococcus_faecalis_upregulated
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00032062:age_regulated_genes
WBPaper00035479:daf-16(RNAi)_upregulated
WBPaper00035873:dpy-10_regulated
WBPaper00035892:Y.pestis_regulated
WBPaper00036286:Pattern_C
WBPaper00038427:lin-54_embryo_changed
WBPaper00039851:Live_C_albicans_vs_HK_OP50
WBPaper00040426:CYD-1_CDK-4_downregulated
WBPaper00040823:alg-1(gk214)_upregulated
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040876:mir-35_downregulated
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_24h
WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00044091:Bpseudomallei_repressed_4h
WBPaper00044091:Bpseudomallei_repressed_8h
WBPaper00044091:Bpseudomallei_repressed_12h
WBPaper00045263:0.1mM-paraquat_downregulated
WBPaper00045673:colistin_upregulated
WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
WBPaper00049311:AgNO3_regulated
WBPaper00057098:SiO2-nanoparticles_downregulated
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
[cgc5976]:class_2
[cgc6390]:Cluster_C
Interaction (123)
Map_infoMapIIPosition3.46558Error0.000297
PositivePositive_cloneVW02B12LInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
Reference (28)
RemarkSequence From: Pujol Nathalie via ACEDB feedback page <pujol@lgpd.univ-mrs.fr>
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene