WormBase Tree Display for Gene: WBGene00004274

WBGene00004274 SMap: S_parent: Sequence: F53G12
  Identity: Version: 1
    Name: CGC_name: rab-11.1 Person_evidence: WBPerson451
      Sequence_name: F53G12.1
      Molecular_name: F53G12.1
        F53G12.1.1
        CE11006
      Other_name: rab-11 Paper_evidence: WBPaper00034709
        CELE_F53G12.1 Accession_evidence: NDB BX284601
      Public_name: rab-11.1
    DB_info: Database: AceView gene 1A582
        WormQTL gene WBGene00004274
        WormFlux gene WBGene00004274
        NDB locus_tag CELE_F53G12.1
        Panther gene CAEEL|WormBase=WBGene00004274|UniProtKB=O01803
          family PTHR47979
        NCBI gene 171601
        RefSeq protein NM_058274.6
        SwissProt UniProtAcc O01803
        TREEFAM TREEFAM_ID TF300099
        UniProt_GCRP UniProtAcc O01803
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rab
    Allele (49)
    Strain: WBStrain00040386
      WBStrain00040387
    RNASeq_FPKM (74)
    GO_annotation (37)
    Contained_in_operon: CEOP1957
    Ortholog (43)
    Paralog (32)
    Structured_description: Concise_description: rab-11.1 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; RAB-11.1 activity is required for completion of the final stages of cytokinesis during early embryogenesis and for efficient uptake of yolk proteins during oocyte development; RAB-11.1 is also required for normal peripheral localization of nuclei in the synctial germ cell in the ovary and for regulated secretion of CAV-1-containing cortical granules following fertilization; RAB-11.1 localizes to recycling endosomes and to cortical granules. Paper_evidence: WBPaper00003831
            WBPaper00004697
            WBPaper00027018
            WBPaper00032152
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Feb 2011 00:00:00
      Automated_description: Predicted to enable GTP binding activity and GTPase activity. Involved in several processes, including eggshell formation; membrane addition at site of mitotic cytokinesis; and vesicle-mediated transport. Located in Golgi trans cisterna membrane; cortical granule; and recycling endosome. Expressed in gonad. Is an ortholog of human RAB11A (RAB11A, member RAS oncogene family). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F53G12.1
    Corresponding_transcript: F53G12.1.1
    Other_sequence: HCC06822_1
      CB036341.1
      EX011157.1
      JI168981.1
      EX012022.1
      EX539833.1
      EX538093.1
      ACC10580_1
      HBC01223_1
      PEC00185_1
      ES740180.1
      MC00298
      PTC00503_1
      FK670252.1
      HG09424
      SC00079
      PPC00105_1
      Acan_isotig11281
      RSC01892_1
      LSC01103_1
      ACC08164_1
      Oden_isotig20947
      EX565885.1
      GO252888.1
      Tcir_isotig29583
      FC554661.1
      Tcol_isotig00266
      PTC00293_1
      JI210752.1
      JI469589.1
      EX552528.1
      HGC02605_1
      DN558269.1
      EX008541.1
      EX555716.1
      Tcol_isotig08505
      JI180844.1
      CJC14228_1
      CRC08245_1
      MIC07666
      Dviv_isotig06456
      AE04650
      JI165838.1
      GR978276.1
      GW409090.1
      PP00564
      Tcol_isotig17520
      Acan_isotig09084
      GR978098.1
      TSC02094_1
      XIC01621_1
      RS06244
      GW406715.1
      Tcol_isotig00267
      Oden_isotig18226
      PT01015
      CJC11199_1
      SC00122
      Name_isotig02027
      CJC01409_1
      Tcol_isotig08503
      ACC03780_1
      SS01500
      DIC01130_1
      PT01510
      Acan_isotig10935
      CJC03008_1
      DI01916
      FD517330.1
      EX555791.1
      MHC08075_1
      Tcol_isotig00268
      MH09727
      EX557842.1
      HG02172
      ES409718.1
      GR978737.1
      Dviv_isotig06455
      SSC00057_1
      Dviv_isotig06454
      Tcol_isotig20747
      AYC04557_1
      CR02753
      XI03844
      NB06520
      ES743619.1
      Oden_isotig19767
      HG09781
      EX565771.1
      NB06515
      BXC03429_1
      CR11386
      PSC02242_2
      JI475488.1
      TS03515
      FK809953.1
      MHC08075_2
      Dviv_isotig06457
      EX910197.1
      CRC07980_1
      CBC00182_1
      NB06628
      ACC25106_1
      GR978332.1
      Dviv_isotig06458
      NBC00269_1
      Hbac_isotig02455
      TDC02048_1
      Acan_isotig12438
      CSC00114_1
      HC00631
      ES740230.1
      MH09735
      CRC01108_1
      CGC00960_1
      MH01251
      EX015131.1
      PE00225
      EX014514.1
      FD515594.1
      ES411455.1
      HGC08215_1
      CR07973
      MCC01084_1
    Associated_feature: WBsf648892
      WBsf663857
      WBsf663858
      WBsf218867
      WBsf218868
      WBsf218869
      WBsf218870
      WBsf218871
  Experimental_info: RNAi_result (31)
    Expr_pattern: Expr4018
      Expr4949
      Expr8340
      Expr8341
      Expr8956
      Expr1022979
      Expr1032113
      Expr1151979
      Expr2015214
      Expr2033448
    Drives_construct: WBCnstr00012362
    Construct_product (24)
    Antibody: WBAntibody00001208
      WBAntibody00001396
      WBAntibody00001957
    Microarray_results (23)
    Expression_cluster: WBPaper00032528:L3_enriched
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038118:stress_upregulated_N2
      WBPaper00038289:oocyte_protein
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040285:H2S_24hr_upregulated
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_Day5
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_downregulated
      WBPaper00048988:daf-2(e1370)_daf-16(mu86)_upregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050448:KGB-1-induced
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050698:DEP-1_interacting
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051558:aging_regulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_embryo_SMARTseq
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058801:ceh-60(lst466)_upregulated_protein
      WBPaper00059174:MEG-3_interacting
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:dld-1-skn-1_16701
      WBPaper00061527:gpb-1_3783-C48A7.2_22459
      WBPaper00061527:T23B5.3_15993-C17D12.1
      WBPaper00061651:Distal_tip_cell_enriched
      WBPaper00061651:Rectal_gland_enriched
      WBPaper00061651:Spermatheca_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00061800:miR-85(n4117)_downregulated_20C
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064201:SNA-3_interacting
      WBPaper00064494:postdauer_upregulated_AWA
      WBPaper00064716:paraquat_upregulated
      WBPaper00064750:0.1mg-nanoplastics_upregulated_protein
      WBPaper00064750:1mg-nanoplastics_upregulated_protein
      WBPaper00064750:10mg-nanoplastics_upregulated_protein
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065373:Cisplatin_upregulated_WT
      cgc4489_group_8
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00027111:eri-1(mg366)_upregulated
      WBPaper00027111:rde-3(r459)_upregulated
      WBPaper00027758:Regulated_genes_not_in_group
      WBPaper00030839:Larval_A_Class
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00034739:N2lessDR1350
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_F
      WBPaper00037695:LD_DD_6-day
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00038231:Cry5B_2-fold_upregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040821:Au-NP_regulated
      WBPaper00040963:TA100_up
      WBPaper00040963:TA200_up
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042234:xpa-1_upregulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00048989:N2_rapamycin_upregulated
    Interaction (110)
  Map_info: Map: I Position: -19.8403 Error: 0.203444
    Positive: Positive_clone: F53G12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5490
    Pseudo_map_position
  Reference (42)
  Remark: Sequence connection from [Kuwabara PE]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene