WormBase Tree Display for Gene: WBGene00000863

WBGene00000863 SMap: S_parent: Sequence: ZK507
  Identity: Version: 2
    Name: CGC_name: cya-1 Paper_evidence: WBPaper00002206
      Sequence_name: ZK507.6
      Molecular_name: ZK507.6
        ZK507.6.1
        CE03820
      Other_name: CELE_ZK507.6 Accession_evidence: NDB BX284603
      Public_name: cya-1
    DB_info: Database: WormFlux gene WBGene00000863
        NDB locus_tag CELE_ZK507.6
        Panther gene CAEEL|WormBase=WBGene00000863|UniProtKB=P34638
          family PTHR10177
        NCBI gene 176287
        RefSeq protein NM_066617.10
        SwissProt UniProtAcc P34638
        TREEFAM TREEFAM_ID TF101002
        UniProt_GCRP UniProtAcc P34638
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 01 May 2012 15:45:01 WBPerson2970 Event: Acquires_merge: WBGene00013981
              Name_change: Sequence_name: ZK507.6
      Acquires_merge: WBGene00013981
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cya
    Allele (35)
    Legacy_information: [C.elegansII] NMK. Encodes predicted cyclin A. [KB]
    Strain: WBStrain00054800
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog: WBGene00029121 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00055167 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00154960 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00152961 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00148017 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00119238 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00079098 Caenorhabditis remanei From_analysis: TreeFam
            WormBase-Compara
      WBGene00066702 Caenorhabditis remanei From_analysis: TreeFam
            WormBase-Compara
      WBGene00065755 Caenorhabditis remanei From_analysis: TreeFam
            WormBase-Compara
      WBGene00065754 Caenorhabditis remanei From_analysis: TreeFam
            WormBase-Compara
      WBGene00102744 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00227740 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g5801 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g7003 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g18064 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g20129 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g3348 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP32.g16109 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g6264 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g6406 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g9096 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00132.g5212 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-cya-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g9754 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01713.g22681 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_05680 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_06148 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_06149 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_07489 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_009356 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_020959 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_020961 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g03705 Oscheius tipulae From_analysis: WormBase-Compara
      Sp34_30259700 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g8547 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00246337 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00289041 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000000038 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Panther
      SGD:S000004812 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Panther
      SGD:S000006177 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Panther
      FB:FBgn0000404 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-020418-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040311-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            Panther
            SonicParanoid
      HGNC:1578 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:1577 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:108042 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:108069 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:621059 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1310639 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
    Paralog (13)
    Structured_description: Concise_description: cya-1 encodes an A-type cyclin; loss of cya-1 via RNAi results in sterility but no defects in embryonic cell divisions, or embryonic lethality, is observed; CYA-1 is predicted to be a substrate of germ-line MPK-1/ERK activity that functions to regulate oocyte organization and differentiation. Paper_evidence: WBPaper00002206
            WBPaper00032961
            WBPaper00035305
          Curator_confirmed: WBPerson1843
          Date_last_updated: 19 Apr 2010 00:00:00
      Automated_description: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in meiotic cell cycle. Predicted to be located in cytoplasm and nucleus. Predicted to be part of cyclin A2-CDK2 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; embryonal carcinoma; and prostate cancer. Is an ortholog of human CCNA1 (cyclin A1) and CCNA2 (cyclin A2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1577)
      DOID:3308 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1578)
      DOID:9119 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1577)
  Molecular_info: Corresponding_CDS: ZK507.6
    Corresponding_transcript: ZK507.6.1
    Other_sequence (17)
    Associated_feature: WBsf655464
      WBsf993573
      WBsf993574
      WBsf993575
      WBsf1015545
      WBsf1015546
      WBsf227245
      WBsf227246
  Experimental_info: RNAi_result: WBRNAi00006081 Inferred_automatically: RNAi_primary
      WBRNAi00111768 Inferred_automatically: RNAi_primary
      WBRNAi00059467 Inferred_automatically: RNAi_primary
      WBRNAi00022037 Inferred_automatically: RNAi_primary
      WBRNAi00007172 Inferred_automatically: RNAi_primary
      WBRNAi00061963 Inferred_automatically: RNAi_primary
      WBRNAi00022036 Inferred_automatically: RNAi_primary
      WBRNAi00027640 Inferred_automatically: RNAi_primary
      WBRNAi00059468 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1030531
      Expr1162890
      Expr2010644
      Expr2028884
    Drives_construct: WBCnstr00037240
    Construct_product: WBCnstr00037240
    Microarray_results (18)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046691:AB_enriched
      WBPaper00046887:WNT-target
      WBPaper00048762:FOG-3_associated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058886:anp-1(ok608)_downregulated
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061340:ABarpaaa_lineage
      WBPaper00061340:AIN_parent
      WBPaper00061340:AMso_parent
      WBPaper00061340:Body_wall_muscle
      WBPaper00061340:Ciliated_amphid_neuron
      WBPaper00061340:Ciliated_non_amphid_neuron
      WBPaper00061340:DVC_parent
      WBPaper00061340:Excretory_cell_parent
      WBPaper00061340:g1A_parent
      WBPaper00061340:g2_parent
      WBPaper00061340:M1_parent
      WBPaper00061340:M4_parent
      WBPaper00061340:Neuroblast_ADF_AWB
      WBPaper00061340:Neuroblast_ALA_RMED
      WBPaper00061340:Neuroblast_ASG_AWA
      WBPaper00061340:Neuroblast_ASH_RIB
      WBPaper00061340:Neuroblast_AVG_RIR
      WBPaper00061340:Neuroblast_AWC_SAAVx
      WBPaper00061340:Neuroblast_BAG_SMDVx
      WBPaper00061340:Neuroblast_HSN_PHB
      WBPaper00061340:Neuroblast_M2_M3
      WBPaper00061340:Neuroblast_PVC_LUA
      WBPaper00061340:OLQ_parent
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061340:Parent_of_AMsh_URB
      WBPaper00061340:Parent_of_exc_gland_AVK
      WBPaper00061340:Parent_of_g1P_I3
      WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V
      WBPaper00061340:Parent_of_hyp3_ILsoDx
      WBPaper00061340:Parent_of_K_Kprime
      WBPaper00061340:Pharyngeal_neuron
      WBPaper00061340:PLM_ALN_grandparent
      WBPaper00061340:PLM_ALN_great_grandparent
      WBPaper00061340:RID_parent
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061527:cyy-1_3136-hcf-1_2478
      WBPaper00061527:pcn-1-cyb-3_17196
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064494:postdauer_downregulated_AWA
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_5_2
      cgc4489_group_2
      cgc4489_group_5
      WBPaper00025032:cluster_7
      WBPaper00025032:cluster_17
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_F
      WBPaper00037611:RNP-8-associated
      WBPaper00038060:SUMO-1_upregulated
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_0.2mM_Down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00042258:DA1877_downregulated_GravidAdult
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
    Interaction: WBInteraction000520790
      WBInteraction000521994
      WBInteraction000524377
      WBInteraction000548871
  Map_info: Map: III Position: 0.164672
    Positive: Positive_clone: KB#L2E
        ZK507 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene