WormBase Tree Display for Gene: WBGene00016097

WBGene00016097 SMap: S_parent: Sequence: C25E10
  Identity: Version: 1
    Name: Sequence_name: C25E10.8
      Molecular_name: C25E10.8
        C25E10.8.1
        CE06870
      Other_name: CELE_C25E10.8 Accession_evidence: NDB BX284605
      Public_name: C25E10.8
    DB_info: Database: AceView gene 5J528
        WormQTL gene WBGene00016097
        WormFlux gene WBGene00016097
        NDB locus_tag CELE_C25E10.8
        Panther gene CAEEL|WormBase=WBGene00016097|UniProtKB=Q18157
          family PTHR23259
        NCBI gene 182892
        RefSeq protein NM_001383365.2
        TREEFAM TREEFAM_ID TF321057
        TrEMBL UniProtAcc Q18157
        UniProt_GCRP UniProtAcc Q18157
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:57 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
    Status: Live
  Gene_info: Biotype: SO:0001217
    Allele (16)
    Strain: WBStrain00033922
      WBStrain00036472
    RNASeq_FPKM (74)
    GO_annotation: 00060304
      00060305
      00060306
      00060307
    Ortholog (17)
    Paralog: WBGene00012509 Caenorhabditis elegans From_analysis: Panther
      WBGene00015076 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00015683 Caenorhabditis elegans From_analysis: Panther
      WBGene00023417 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018112 Caenorhabditis elegans From_analysis: Panther
      WBGene00009328 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00011328 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013481 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013485 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016096 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: C25E10.8 encodes a putative secreted TIL-domain protease inhibitorparalogous to SWM-1, ISL-1, and the products of 11 other C. elegansgenes; C25E10.8 and its relatives are collectively similar to otherTIL-domain protease inhibitors from nematodes, insects, and vertebrates;despite both swm-1 and C25E10.8 being mutated by the swm-1(ok1193)deletion, transgenic rescue of swm-1(ok1193) by SWM-1 alone leaves maleswith no obvious residual phenotype, indicating that C25E10.8 has noconspicuous function in vivo. Paper_evidence: WBPaper00027081
            WBPaper00029338
            WBPaper00029339
            WBPaper00029340
            WBPaper00029341
            WBPaper00029342
            WBPaper00029343
          Curator_confirmed: WBPerson567
          Date_last_updated: 09 May 2007 00:00:00
      Automated_description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. Expressed in intestine. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C25E10.8
    Corresponding_transcript: C25E10.8.1
    Other_sequence: CSC00722_1
      NB07299
      NBC01164_1
      FD516388.1
    Associated_feature: WBsf652882
      WBsf234168
  Experimental_info: RNAi_result: WBRNAi00029197 Inferred_automatically: RNAi_primary
      WBRNAi00041190 Inferred_automatically: RNAi_primary
      WBRNAi00011165 Inferred_automatically: RNAi_primary
      WBRNAi00088993 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram419
      Expr3789
      Expr1018177
      Expr1145221
      Expr2001083
      Expr2019304
    Drives_construct: WBCnstr00001073
      WBCnstr00011660
    Microarray_results: SMD_C25E10.8
      185690_at
      A_12_P119063
      A_12_P171162
      A_12_P171164
      Aff_C25E10.8
      GPL13394_WBGene00016097
      GPL13914_C25E10.8
      GPL14144_C25E10.8_335-394_0.932_2_A
      GPL19516_CGZ0005903
      GPL21109_C25E10.8.1
      GPL3518_CE06870
      GPL8304_CE_WBGene00016097_A
      GPL8673_C25E10_8P00077
      GPL8673_C25E10_8P00090
      GPL8673_C25E10_8P00302
      GPL9450_C25E10.8
      cea2.c.34167
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036291:ung-1_regulated
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037682:sma-2_downregulated
      WBPaper00037946:EGL-5_interacting
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040285:H2S_12hr_upregulated
      WBPaper00040285:H2S_24hr_upregulated
      WBPaper00040420:FLP_enriched
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044005:DAF-16_upregulated
      WBPaper00044030:nhr-8(hd117)_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045257:bar-1(ga80)_upregulated
      WBPaper00045521:Spermatogenic
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00045934:wrn-1(gk99)_downregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_downregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048980:aging_upregulated
      WBPaper00048988:daf-2(e1370)_upregulated_neuron
      WBPaper00048988:daf-16(mu86)_downregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049018:ham-3(RNAi)_downregulated
      WBPaper00049098:hrde-1(tm1200)-induced_23C
      WBPaper00049489:AMsh-glia_enriched
      WBPaper00049498:npr-1(ur89)_regulated_1
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050332:daf-16(RNAi)_downregulated
      WBPaper00050332:juglone_upregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050448:KGB-1-induced
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050743:elli-1(sam-3)_upregulated
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050903:mir-35-41(nDf50)_20C_upregulated
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053318:Aging_upregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_upregulated_mRNA
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053810:clk-1(qm30)_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00054872:egl-9(sa307)_upregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056139:gut-microbiota_upregulated
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056218:daf-16(mu86)_upregulated_Day5
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00059421:daf-3(mgDf90)_upregulated
      WBPaper00059537:ngn-1(ok2200)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059735:glucose_downregulated_lpin-1(RNAi)
      WBPaper00059763:neuron_expressed
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061340:AIN
      WBPaper00061340:g1P
      WBPaper00061340:Pharyngeal_intestinal_valve
      WBPaper00061340:pm7
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061390:daf-22(ok693)_ascarosides_downregulated
      WBPaper00061466:nath-10(icb99)_upregulated
      WBPaper00061527:W01F3.2_1554-Y106G6D.8
      WBPaper00061651:ADF_enriched
      WBPaper00061651:ASEL_enriched
      WBPaper00061651:ASER_enriched
      WBPaper00061651:ASG_enriched
      WBPaper00061651:AWA_enriched
      WBPaper00061651:PHsh_enriched
      WBPaper00061651:Rectal_gland_enriched
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061952:daf-18(nr2037)_downregulated
      WBPaper00061952:daf-18(yh1)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062237:dnj-21(RNAi)_upregulated_protein
      WBPaper00062347:blmp-1(tm548)_upregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062590:Aging_upregulated_neuron
      WBPaper00062715:blmp-1(s71)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064158:xpo-1(RNAi)_upregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064716:paraquat_downregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064952:Day5_vs_L4_upregulated_25C
      WBPaper00064952:Day10_vs_Day1_upregulated_20C
      WBPaper00064952:Day10_vs_Day1_upregulated_25C
      WBPaper00064952:Day10_vs_Day5_upregulated_20C
      WBPaper00064952:Day10_vs_Day5_upregulated_25C
      WBPaper00064952:Day10_vs_L4_upregulated_20C
      WBPaper00064952:Day10_vs_L4_upregulated_25C
      WBPaper00065029:cadmium_upregulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065392:Lb.delbrueckii_downregulated
      WBPaper00065392:Lb.plantarum_downregulated
      WBPaper00065392:Lb.reuteri_downregulated
      WBPaper00065392:Lb.rhamnosus_downregulated
      WBPaper00065392:P.pentosaceus_downregulated
      WBPaper00065835:Day5_vs_Day1_upregulated
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:30_5
      WBPaper00065841:38_0
      WBPaper00065841:41_1
      WBPaper00065841:141_0
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066204:CdCl2_upregulated_mRNA
      cgc4489_group_13
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00027111:rde-3(ne298)_upregulated
      WBPaper00027111:rrf-3(pk1426)_upregulated
      WBPaper00028564:CeMM_vs_NGM_upregulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00029437:rde-4_upregulated
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00031060:2-deoxy-D-glucose_upregulated
      WBPaper00031832:slr-2_regulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_D
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00038231:Cry5B_2-fold_upregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040876:mir-35_upregulated
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041207:CE_dauer_up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041609:hpl-1_hpl-2_upregulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042128:gei-8(ok1671)_upregulated
      WBPaper00042234:xpa-1_upregulated
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00045015:nhr-25(RNAi)_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5976]:class_1
    Interaction (29)
  Map_info: Positive: Positive_clone: C25E10 Inferred_automatically: From sequence, transcript, pseudogene data
    Interpolated_map_position: V 1.91417
  Reference: WBPaper00026980
    WBPaper00028564
  Method: Gene