WormBase Tree Display for Gene: WBGene00023417
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| WBGene00023417 | SMap | S_parent | Sequence | C25E10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | swm-1 | Person_evidence | WBPerson620 | |||||
| WBPerson1547 | |||||||||
| Sequence_name | C25E10.9 | ||||||||
| Molecular_name | C25E10.9 | ||||||||
| C25E10.9.1 | |||||||||
| CE06871 | |||||||||
| Other_name | isl-2 | ||||||||
| CELE_C25E10.9 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | swm-1 | ||||||||
| DB_info | Database | AceView | gene | 5J530 | |||||
| WormQTL | gene | WBGene00023417 | |||||||
| WormFlux | gene | WBGene00023417 | |||||||
| NDB | locus_tag | CELE_C25E10.9 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00023417|UniProtKB=Q18158 | |||||||
| family | PTHR23259 | ||||||||
| NCBI | gene | 182893 | |||||||
| RefSeq | protein | NM_072945.4 | |||||||
| SwissProt | UniProtAcc | Q18158 | |||||||
| UniProt_GCRP | UniProtAcc | Q18158 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 02 Jul 2004 16:55:44 | WBPerson1971 | Event | Created | |||
| 2 | 15 Nov 2004 14:51:00 | WBPerson2970 | Event | Acquires_merge | WBGene00016098 | ||||
| 3 | 18 Jul 2005 13:34:00 | WBPerson2970 | Name_change | CGC_name | swm-1 | ||||
| Acquires_merge | WBGene00016098 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | swm | ||||||||
| Allele (20) | |||||||||
| Strain | WBStrain00000289 | ||||||||
| WBStrain00000293 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (22) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | swm-1 encodes a putative secreted TIL-domain protease inhibitor that, inmales, inhibits unpolarized round spermatids from remodelling themselvesinto motile spermatozoa until their transfer to a hermaphrodite; SWM-1is also required for efficient sperm transfer, and thus for malefertility; SWM-1 is biologically active from spermatogenesis in L4larvae onward into adulthood, and functions non-autonomously, probablybeing expressed in germline; SWM-1-inhibited spermatid activationrequires SPE-8, SPE-12, and SPE-27; SWM-1 is active in hermaphroditesbut is not strongly required for fertility; SWM-1 is paralogous toC25E10.8, ISL-1, and the products of 11 other C. elegans genes; SWM-1and its relatives are collectively similar to other TIL-domain proteaseinhibitors from nematodes, insects, and vertebrates, including theDrosophila melanogaster seminal fluid protein Acp62F; SWM-1 contains twotandem TIL domains, missense mutations of which partially complement oneanother in vivo, and which therefore may inhibit two differentproteases; mutant swm-1 males can trans-activate hermaphroditespermatids by mating, but prematurely remodel their own spermatids,which then generally fail to be transferred to hermaphrodites;sporadically or artificially transferred swm-1 mutant sperm do, however,fertilize hermaphrodite eggs normally. | Paper_evidence | WBPaper00027081 | |||||
| WBPaper00029338 | |||||||||
| WBPaper00029339 | |||||||||
| WBPaper00029340 | |||||||||
| WBPaper00029341 | |||||||||
| WBPaper00029342 | |||||||||
| WBPaper00029343 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 09 May 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable serine-type endopeptidase inhibitor activity. Involved in spermatid development. Located in extracellular space and secretory vesicle. Expressed in body wall musculature; coelomocyte; reproductive tract; and in male. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C25E10.9 | |||||||
| Corresponding_CDS_history | C25E10.9b:wp252 | ||||||||
| Corresponding_transcript | C25E10.9.1 | ||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf652883 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00011166 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00029198 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041191 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr14579 | ||||||||
| Expr14580 | |||||||||
| Expr14581 | |||||||||
| Expr14582 | |||||||||
| Expr14584 | |||||||||
| Expr1012350 | |||||||||
| Expr1145222 | |||||||||
| Expr2017153 | |||||||||
| Expr2035289 | |||||||||
| Drives_construct | WBCnstr00040375 | ||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (173) | |||||||||
| Interaction (207) | |||||||||
| Map_info | Map | V | Position | 1.9142 | Error | 0.000661 | |||
| Positive | Positive_clone | C25E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5679 | |||||||
| Pos_neg_data | 10751 | ||||||||
| 10752 | |||||||||
| 10753 | |||||||||
| Reference (24) | |||||||||
| Method | Gene |
