WormBase Tree Display for Gene: WBGene00023417
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WBGene00023417 | SMap | S_parent | Sequence | C25E10 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | swm | ||||||
Allele (20) | |||||||
Strain | WBStrain00000289 | ||||||
WBStrain00000293 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (12) | |||||||
Ortholog (22) | |||||||
Paralog (12) | |||||||
Structured_description | Concise_description | swm-1 encodes a putative secreted TIL-domain protease inhibitor that, inmales, inhibits unpolarized round spermatids from remodelling themselvesinto motile spermatozoa until their transfer to a hermaphrodite; SWM-1is also required for efficient sperm transfer, and thus for malefertility; SWM-1 is biologically active from spermatogenesis in L4larvae onward into adulthood, and functions non-autonomously, probablybeing expressed in germline; SWM-1-inhibited spermatid activationrequires SPE-8, SPE-12, and SPE-27; SWM-1 is active in hermaphroditesbut is not strongly required for fertility; SWM-1 is paralogous toC25E10.8, ISL-1, and the products of 11 other C. elegans genes; SWM-1and its relatives are collectively similar to other TIL-domain proteaseinhibitors from nematodes, insects, and vertebrates, including theDrosophila melanogaster seminal fluid protein Acp62F; SWM-1 contains twotandem TIL domains, missense mutations of which partially complement oneanother in vivo, and which therefore may inhibit two differentproteases; mutant swm-1 males can trans-activate hermaphroditespermatids by mating, but prematurely remodel their own spermatids,which then generally fail to be transferred to hermaphrodites;sporadically or artificially transferred swm-1 mutant sperm do, however,fertilize hermaphrodite eggs normally. | Paper_evidence | WBPaper00027081 | |||
WBPaper00029338 | |||||||
WBPaper00029339 | |||||||
WBPaper00029340 | |||||||
WBPaper00029341 | |||||||
WBPaper00029342 | |||||||
WBPaper00029343 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 09 May 2007 00:00:00 | ||||||
Automated_description | Predicted to enable serine-type endopeptidase inhibitor activity. Involved in spermatid development. Located in extracellular space and secretory vesicle. Expressed in body wall musculature; coelomocyte; reproductive tract; and in male. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C25E10.9 | |||||
Corresponding_CDS_history | C25E10.9b:wp252 | ||||||
Corresponding_transcript | C25E10.9.1 | ||||||
Other_sequence (14) | |||||||
Associated_feature | WBsf652883 | ||||||
Experimental_info | RNAi_result | WBRNAi00011166 | Inferred_automatically | RNAi_primary | |||
WBRNAi00029198 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00041191 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr14579 | ||||||
Expr14580 | |||||||
Expr14581 | |||||||
Expr14582 | |||||||
Expr14584 | |||||||
Expr1012350 | |||||||
Expr1145222 | |||||||
Expr2017153 | |||||||
Expr2035289 | |||||||
Drives_construct | WBCnstr00040375 | ||||||
Microarray_results (28) | |||||||
Expression_cluster (173) | |||||||
Interaction (207) | |||||||
Map_info | Map | V | Position | 1.9142 | Error | 0.000661 | |
Positive | Positive_clone | C25E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 5679 | |||||
Pos_neg_data | 10751 | ||||||
10752 | |||||||
10753 | |||||||
Reference (24) | |||||||
Method | Gene |