WormBase Tree Display for Gene: WBGene00007984

WBGene00007984 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 2
    Name: CGC_name: irx-1 Person_evidence: WBPerson83
            WBPerson3132
            WBPerson1997
      Sequence_name: C36F7.1
      Molecular_name: C36F7.1
        C36F7.1.1
        CE42075
      Other_name: CELE_C36F7.1 Accession_evidence: NDB BX284601
      Public_name: irx-1
    DB_info: Database: AceView gene 1K114
        WormQTL gene WBGene00007984
        WormFlux gene WBGene00007984
        NDB locus_tag CELE_C36F7.1
        Panther gene CAEEL|WormBase=WBGene00007984|UniProtKB=Q93348
          family PTHR11211
        NCBI gene 172789
        RefSeq protein NM_060132.7
        SwissProt UniProtAcc Q93348
        TREEFAM TREEFAM_ID TF319371
        UniProt_GCRP UniProtAcc Q93348
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:48 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 18 Jul 2005 13:34:00 WBPerson2970 Name_change: CGC_name: irx-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: irx
    Allele (42)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Contained_in_operon: CEOP1895
    Ortholog (62)
    Structured_description: Concise_description: irx-1 encodes a homeodomain-containing protein that is most similar to members of the Iroquois subclass of TALE (three amino acid loop extension) superclass atypical homeodomain proteins; IRX-1 functions downstream of the UNC-55 nuclear receptor in a transcriptional regulatory network that controls remodeling of the GABAergic DD neuron synapses during larval development. Paper_evidence: WBPaper00002937
            WBPaper00004402
            WBPaper00024497
            WBPaper00025054
            WBPaper00040363
          Curator_confirmed: WBPerson1843
          Date_last_updated: 28 Oct 2011 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell development; neuron differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in head muscle; hypodermis; intestine; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in congenital heart disease and dilated cardiomyopathy. Is an ortholog of several human genes including IRX1 (iroquois homeobox 1); IRX3 (iroquois homeobox 3); and IRX5 (iroquois homeobox 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1682 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14358)
      DOID:12930 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14361)
  Molecular_info: Corresponding_CDS: C36F7.1
    Corresponding_CDS_history: C36F7.1:wp187
    Corresponding_transcript: C36F7.1.1
    Other_sequence: HBC22230_1
      Dviv_isotig23212
      Oden_isotig21744
      JI167499.1
      MHC03189_1
      TX00146
      Hbac_isotig02767
      ES739950.1
      MH06638
    Associated_feature: WBsf649483
      WBsf978267
      WBsf984727
      WBsf984728
      WBsf984729
      WBsf984730
      WBsf1010391
      WBsf1010392
      WBsf1010393
    Transcription_factor: WBTranscriptionFactor000355
  Experimental_info: RNAi_result (18)
    Expr_pattern: Expr7467
      Expr9678
      Expr10339
      Expr15623
      Expr1025765
      Expr1033472
      Expr1146080
      Expr2012868
      Expr2031102
    Drives_construct: WBCnstr00009282
      WBCnstr00012611
      WBCnstr00015265
    Construct_product: WBCnstr00009282
      WBCnstr00009289
      WBCnstr00009290
      WBCnstr00016568
      WBCnstr00021770
    Microarray_results (25)
    Expression_cluster: WBPaper00028867:HLH-1_induced_TF
      WBPaper00032031:DConiospora_downregulated_OligoArray_24h
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00035197:fer-1_downregulated
      WBPaper00037946:LIN-39_interacting
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050094:mes-6(bn66)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053810:sod-2(ok1030)_upregulated
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056167:ifo-1(kc2)_upregulated
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056619:CEPsh_enriched
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AIB
      WBPaper00061340:AIM
      WBPaper00061340:AMso_parent
      WBPaper00061340:AVG
      WBPaper00061340:Body_wall_muscle
      WBPaper00061340:Coelomocyte
      WBPaper00061340:Excretory_duct_and_pore
      WBPaper00061340:g2
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:g2_parent
      WBPaper00061340:hmc
      WBPaper00061340:hmc_and_homolog
      WBPaper00061340:hmc_homolog
      WBPaper00061340:mc3
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:Neuroblast_I6_M5
      WBPaper00061340:Neuroblast_URX_CEPDx
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3
      WBPaper00061340:Pharyngeal_intestinal_valve
      WBPaper00061340:pm6
      WBPaper00061340:pm7
      WBPaper00061340:pm8
      WBPaper00061340:Rectal_cell
      WBPaper00061340:RIC_parent
      WBPaper00061340:RIS
      WBPaper00061466:nath-10(icb99)_upregulated
      WBPaper00061466:nath-10(icb102)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:sol-1-jnk-1_18695
      WBPaper00062184:PA14_downregulated
      WBPaper00062590:Aging_upregulated_intestine
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065841:1_2
      WBPaper00065841:34_0
      WBPaper00065841:37_0
      WBPaper00065841:56_0
      WBPaper00065841:62_0
      WBPaper00065841:64_0
      WBPaper00065841:78_0
      WBPaper00065841:96_0
      WBPaper00065841:117_0
      WBPaper00065841:123_0
      WBPaper00065841:126_0
      WBPaper00065841:128_0
      WBPaper00065841:131_0
      WBPaper00065841:135_0
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_6_5
      WBPaper00025032:cluster_12
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030985:Enterococcus_faecalis_downregulated
      WBPaper00030985:Photorhabdus_luminescens_downregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00034739:N2moreDR1350
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040963:Q50_down
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_5
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(23_min)
    Interaction: WBInteraction000006290
      WBInteraction000339569
      WBInteraction000342398
      WBInteraction000417888
      WBInteraction000437442
      WBInteraction000456088
      WBInteraction000460864
      WBInteraction000505165
      WBInteraction000505208
      WBInteraction000505344
      WBInteraction000519746
      WBInteraction000519762
      WBInteraction000519763
      WBInteraction000519764
      WBInteraction000519914
      WBInteraction000526355
      WBInteraction000526359
      WBInteraction000526360
      WBInteraction000526361
      WBInteraction000526362
      WBInteraction000526363
      WBInteraction000526364
      WBInteraction000526365
      WBInteraction000526366
      WBInteraction000526367
      WBInteraction000526540
      WBInteraction000527273
      WBInteraction000527710
      WBInteraction000527975
      WBInteraction000534281
      WBInteraction000534694
      WBInteraction000534834
      WBInteraction000535372
      WBInteraction000541782
  Map_info: Map: I Position: 3.80092 Error: 0.000995
    Positive: Positive_clone: C36F7 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5375
        4148
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene