WBGene00004266 | SMap | S_parent | Sequence | C39F7 |
| Identity | Version | 1 |
| | Name | CGC_name | rab-1 | Person_evidence | WBPerson451 |
| | | Sequence_name | C39F7.4 |
| | | Molecular_name | C39F7.4 |
| | | | C39F7.4.1 |
| | | | CE16905 |
| | | Other_name | Rab protein | Paper_evidence | WBPaper00006512 |
| | | | CELE_C39F7.4 | Accession_evidence | NDB | BX284605 |
| | | Public_name | rab-1 |
| | DB_info | Database | AceView | gene | 5B742 |
| | | | WormQTL | gene | WBGene00004266 |
| | | | WormFlux | gene | WBGene00004266 |
| | | | NDB | locus_tag | CELE_C39F7.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00004266|UniProtKB=Q9UAQ6 |
| | | | | family | PTHR24073 |
| | | | NCBI | gene | 178620 |
| | | | RefSeq | protein | NM_070996.7 |
| | | | TrEMBL | UniProtAcc | Q9UAQ6 |
| | | | UniProt_GCRP | UniProtAcc | Q9UAQ6 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | rab |
| | Allele (26) |
| | Strain | WBStrain00002887 |
| | | WBStrain00003426 |
| | | WBStrain00037655 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00100653 |
| | | 00100654 |
| | | 00100655 |
| | | 00100656 |
| | | 00112574 |
| | | 00112575 |
| | Ortholog (47) |
| | Paralog (32) |
| | Structured_description | Concise_description | rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline. | Paper_evidence | WBPaper00006488 |
| | | | | | WBPaper00006510 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 24 Jan 2005 00:00:00 |
| | | Automated_description | Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly and intracellular protein transport. Predicted to be located in endomembrane system. Expressed in tail. Is an ortholog of human RAB1A (RAB1A, member RAS oncogene family); RAB1B (RAB1B, member RAS oncogene family); and RAB1C (RAB1C, member RAS oncogene family (pseudogene)). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C39F7.4 |
| | Corresponding_transcript | C39F7.4.1 |
| | Other_sequence (105) |
| | Associated_feature (18) |
| Experimental_info | RNAi_result (36) |
| | Expr_pattern | Chronogram1249 |
| | | Chronogram1839 |
| | | Expr5476 |
| | | Expr5477 |
| | | Expr1019360 |
| | | Expr1032105 |
| | | Expr1146221 |
| | | Expr2015219 |
| | | Expr2033453 |
| | Drives_construct | WBCnstr00003406 |
| | | WBCnstr00004586 |
| | | WBCnstr00019161 |
| | | WBCnstr00035601 |
| | Construct_product | WBCnstr00016487 |
| | | WBCnstr00035601 |
| | Microarray_results (26) |
| | Expression_cluster | WBPaper00029359_1217 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1353 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1548 |
| | | WBPaper00029359_1604 |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038118:stress_upregulated_N2 |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040965:lipid-droplet_associated_protein |
| | | WBPaper00041072:UTX-1_interacting_protein |
| | | WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046691:P1_enriched |
| | | WBPaper00048988:daf-2(e1370)_daf-16(mu86)_upregulated_neuron |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050514:CEBP-1_interacting |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053388:dauer_regulated_Cluster6 |
| | | WBPaper00053814:25C_downregulated_OP50 |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00054189:aging_regulated_protein |
| | | WBPaper00054189:P.aeruginosa_regulated_protein |
| | | WBPaper00054410:set-26(tm2467)_downregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00058691:CFP-1_interacting_protein |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061377:PAN-1_interacting |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:cdc-42_17192-rab-5_18073 |
| | | WBPaper00061572:oleic-acid-specific_mating_downregulated |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:PVW_enriched |
| | | WBPaper00061651:Spermatheca_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:25C_vs_15C_upregulated_AFD |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | cgc4489_group_8 |
| | | WBPaper00025032:cluster_175 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00036375:depleted_in_PVD_OLL |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5 |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:environmental_prime |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(101_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction | WBInteraction000009570 |
| | | WBInteraction000034256 |
| | | WBInteraction000035975 |
| | | WBInteraction000036540 |
| | | WBInteraction000038401 |
| | | WBInteraction000039105 |
| | | WBInteraction000039767 |
| | | WBInteraction000043883 |
| | | WBInteraction000044541 |
| | | WBInteraction000045118 |
| | | WBInteraction000047178 |
| | | WBInteraction000048891 |
| | | WBInteraction000049611 |
| | | WBInteraction000101850 |
| | | WBInteraction000101955 |
| | | WBInteraction000102843 |
| | | WBInteraction000103974 |
| | | WBInteraction000104638 |
| | | WBInteraction000104639 |
| | | WBInteraction000104764 |
| | | WBInteraction000105796 |
| | | WBInteraction000105812 |
| | | WBInteraction000106181 |
| | | WBInteraction000107066 |
| | | WBInteraction000107242 |
| | | WBInteraction000110160 |
| | | WBInteraction000110489 |
| | | WBInteraction000110644 |
| | | WBInteraction000111105 |
| | | WBInteraction000112239 |
| | | WBInteraction000112293 |
| | | WBInteraction000112794 |
| | | WBInteraction000113555 |
| | | WBInteraction000120752 |
| | | WBInteraction000120777 |
| | | WBInteraction000121741 |
| | | WBInteraction000122573 |
| | | WBInteraction000122825 |
| | | WBInteraction000122826 |
| | | WBInteraction000126017 |
| | | WBInteraction000134090 |
| | | WBInteraction000135594 |
| | | WBInteraction000136354 |
| | | WBInteraction000136434 |
| | | WBInteraction000139061 |
| | | WBInteraction000139354 |
| | | WBInteraction000141629 |
| | | WBInteraction000144411 |
| | | WBInteraction000146146 |
| | | WBInteraction000146671 |
| | | WBInteraction000147170 |
| | | WBInteraction000148067 |
| | | WBInteraction000148772 |
| | | WBInteraction000150924 |
| | | WBInteraction000151167 |
| | | WBInteraction000151275 |
| | | WBInteraction000151454 |
| | | WBInteraction000156726 |
| | | WBInteraction000157664 |
| | | WBInteraction000159726 |
| | | WBInteraction000163312 |
| | | WBInteraction000163941 |
| | | WBInteraction000173721 |
| | | WBInteraction000175543 |
| | | WBInteraction000177406 |
| | | WBInteraction000179787 |
| | | WBInteraction000181247 |
| | | WBInteraction000183259 |
| | | WBInteraction000184838 |
| | | WBInteraction000185611 |
| | | WBInteraction000185612 |
| | | WBInteraction000185651 |
| | | WBInteraction000185690 |
| | | WBInteraction000185732 |
| | | WBInteraction000186884 |
| | | WBInteraction000189253 |
| | | WBInteraction000190697 |
| | | WBInteraction000191711 |
| | | WBInteraction000197101 |
| | | WBInteraction000199167 |
| | | WBInteraction000200277 |
| | | WBInteraction000200537 |
| | | WBInteraction000204183 |
| | | WBInteraction000204417 |
| | | WBInteraction000206602 |
| | | WBInteraction000206817 |
| | | WBInteraction000209222 |
| | | WBInteraction000213985 |
| | | WBInteraction000214269 |
| | | WBInteraction000216681 |
| | | WBInteraction000228871 |
| | | WBInteraction000238544 |
| | | WBInteraction000245860 |
| | | WBInteraction000246198 |
| | | WBInteraction000248057 |
| | | WBInteraction000252486 |
| | | WBInteraction000261359 |
| | | WBInteraction000262876 |
| | | WBInteraction000263268 |
| | | WBInteraction000264796 |
| | | WBInteraction000265976 |
| | | WBInteraction000270286 |
| | | WBInteraction000272333 |
| | | WBInteraction000274342 |
| | | WBInteraction000274357 |
| | | WBInteraction000274709 |
| | | WBInteraction000277689 |
| | | WBInteraction000283445 |
| | | WBInteraction000285103 |
| | | WBInteraction000291269 |
| | | WBInteraction000293398 |
| | | WBInteraction000298658 |
| | | WBInteraction000303027 |
| | | WBInteraction000309882 |
| | | WBInteraction000316134 |
| | | WBInteraction000320536 |
| | | WBInteraction000326135 |
| | | WBInteraction000326488 |
| | | WBInteraction000329570 |
| | | WBInteraction000332587 |
| | | WBInteraction000333318 |
| | | WBInteraction000334227 |
| | | WBInteraction000338709 |
| | | WBInteraction000342139 |
| | | WBInteraction000342503 |
| | | WBInteraction000355073 |
| | | WBInteraction000355074 |
| | | WBInteraction000356241 |
| | | WBInteraction000358330 |
| | | WBInteraction000364607 |
| | | WBInteraction000366690 |
| | | WBInteraction000366885 |
| | | WBInteraction000367886 |
| | | WBInteraction000375880 |
| | | WBInteraction000376768 |
| | | WBInteraction000379197 |
| | | WBInteraction000383672 |
| | | WBInteraction000386965 |
| | | WBInteraction000387088 |
| | | WBInteraction000388681 |
| | | WBInteraction000398265 |
| | | WBInteraction000401470 |
| | | WBInteraction000401471 |
| | | WBInteraction000404810 |
| | | WBInteraction000407777 |
| | | WBInteraction000407929 |
| | | WBInteraction000410672 |
| | | WBInteraction000417502 |
| | | WBInteraction000417553 |
| | | WBInteraction000421841 |
| | | WBInteraction000424509 |
| | | WBInteraction000424933 |
| | | WBInteraction000429167 |
| | | WBInteraction000435401 |
| | | WBInteraction000438128 |
| | | WBInteraction000440838 |
| | | WBInteraction000440852 |
| | | WBInteraction000442057 |
| | | WBInteraction000447770 |
| | | WBInteraction000448851 |
| | | WBInteraction000449618 |
| | | WBInteraction000450657 |
| | | WBInteraction000454425 |
| | | WBInteraction000455278 |
| | | WBInteraction000455999 |
| | | WBInteraction000458401 |
| | | WBInteraction000459219 |
| | | WBInteraction000461763 |
| | | WBInteraction000462004 |
| | | WBInteraction000462578 |
| | | WBInteraction000462752 |
| | | WBInteraction000462997 |
| | | WBInteraction000463743 |
| | | WBInteraction000464224 |
| | | WBInteraction000464390 |
| | | WBInteraction000465434 |
| | | WBInteraction000466253 |
| | | WBInteraction000467139 |
| | | WBInteraction000468650 |
| | | WBInteraction000469109 |
| | | WBInteraction000470571 |
| | | WBInteraction000470890 |
| | | WBInteraction000470901 |
| | | WBInteraction000471122 |
| | | WBInteraction000471123 |
| | | WBInteraction000471124 |
| | | WBInteraction000471743 |
| | | WBInteraction000472434 |
| | | WBInteraction000472435 |
| | | WBInteraction000472436 |
| | | WBInteraction000472437 |
| | | WBInteraction000473029 |
| | | WBInteraction000473168 |
| | | WBInteraction000473344 |
| | | WBInteraction000475468 |
| | | WBInteraction000502377 |
| | | WBInteraction000504058 |
| | | WBInteraction000505083 |
| | | WBInteraction000505142 |
| | | WBInteraction000542836 |
| | | WBInteraction000550153 |
| | | WBInteraction000554115 |
| | | WBInteraction000559123 |
| | | WBInteraction000564184 |
| | | WBInteraction000572403 |
| | | WBInteraction000572825 |
| | | WBInteraction000573518 |
| | | WBInteraction000574478 |
| | | WBInteraction000577690 |
| | | WBInteraction000578652 |
| | | WBInteraction000579162 |
| | | WBInteraction000579187 |
| | | WBInteraction000580281 |
| | | WBInteraction000583097 |
| Map_info | Map | V | Position | -19.8459 | Error | 0.000669 |
| | Positive | Positive_clone | C39F7 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (27) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |