WormBase Tree Display for Gene: WBGene00003590

WBGene00003590 SMap: S_parent: Sequence: C28A5
  Identity: Version: 1
    Name: CGC_name: nex-3
      Sequence_name: C28A5.3
      Molecular_name: C28A5.3
        C28A5.3.1
        CE00661
      Other_name: CELE_C28A5.3 Accession_evidence: NDB BX284603
      Public_name: nex-3
    DB_info: Database: AceView gene 3F533
        WormQTL gene WBGene00003590
        WormFlux gene WBGene00003590
        NDB locus_tag CELE_C28A5.3
        Panther gene CAEEL|WormBase=WBGene00003590|UniProtKB=Q27473
          family PTHR10502
        NCBI gene 191716
        RefSeq protein NM_065502.4
        TrEMBL UniProtAcc Q27473
        UniProt_GCRP UniProtAcc Q27473
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nex
    Allele (38)
    Legacy_information: [C.elegansII] NMK. Encodes predicted protein with annexin similarity. [CGC]
    Strain: WBStrain00036168
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (29)
    Paralog: WBGene00003588 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003589 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003591 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: nex-3 encodes an annexin, a member of a family of calcium-dependent phospholipid binding proteins; by homology, NEX-3 could function in a number of processes, such as membrane fusion, cytoskeletal interactions, and intracellular signaling; however, as loss of nex-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of NEX-3 in C. elegans development and/or behavior is not yet known. Paper_evidence (3)
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables phospholipid binding activity and sulfur compound binding activity. Predicted to be located in cytoplasm. Is an ortholog of human ANXA3 (annexin A3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C28A5.3
    Corresponding_transcript: C28A5.3.1
    Other_sequence (36)
    Associated_feature: WBsf992121
      WBsf992122
      WBsf224738
      WBsf224739
  Experimental_info: RNAi_result: WBRNAi00072953 Inferred_automatically: RNAi_primary
      WBRNAi00029289 Inferred_automatically: RNAi_primary
      WBRNAi00011285 Inferred_automatically: RNAi_primary
      WBRNAi00072952 Inferred_automatically: RNAi_primary
      WBRNAi00080498 Inferred_automatically: RNAi_primary
      WBRNAi00005141 Inferred_automatically: RNAi_primary
      WBRNAi00041389 Inferred_automatically: RNAi_primary
      WBRNAi00072954 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8284
      Expr1017980
      Expr1145422
      Expr2013981
      Expr2032221
    Drives_construct: WBCnstr00036020
    Construct_product: WBCnstr00036020
    Antibody: WBAntibody00001200
    Microarray_results (19)
    Expression_cluster: WBPaper00024245:gst-5-binding_control
      WBPaper00028451:Low_abundance_spermatogenesis_enriched
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037682:sma-2_downregulated
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038213:E.coli(LF82)_72h_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00038357:atx-3_regulated_heat-shock
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00042477:prp-8(RNAi)_upregulated_RNAseq
      WBPaper00044037:eat-2_upregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044746:aging_upregulated_Day5
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00045217:prg-1_progressively_regulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00049489:AMsh-glia_enriched
      WBPaper00049498:npr-1(ur89)_regulated_8
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050686:glp-1(e2141)_upregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_enriched
      WBPaper00050990:body-muscle_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051257:Levamisole_upregulated
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053664:ins-11(tm1053)_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053810:clk-1(qm30)_upregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00053814:25C_upregulated_OP50
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:male-tail_expressed
      WBPaper00055648:vulva-uterus_expressed
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056619:CEPsh_enriched
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_protein
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059735:glucose_downregulated_lpin-1(RNAi)
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-infection_12h_regulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ADEsh
      WBPaper00061340:AMsh
      WBPaper00061340:CAN
      WBPaper00061340:CEPsh
      WBPaper00061340:CEPso
      WBPaper00061340:Excretory_duct_and_pore
      WBPaper00061340:hyp3
      WBPaper00061340:ILsh_OLLsh_OLQsh
      WBPaper00061340:ILso
      WBPaper00061340:XXX
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:F54D5.3_7003-F54D5.3_7004
      WBPaper00061651:CEPsh_enriched
      WBPaper00061651:Rectal_gland_enriched
      WBPaper00061823:mex-3(spr9)_downregulated
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062078:NMR-HspB1_regulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062354:H.zoospora_12h_regulated
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00062590:Aging_downregulated_body-wall-muscle
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064005:starvation_upregulated_N2_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064494:postdauer_downregulated_WholeAnimal
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00064952:Day5_vs_L4_upregulated_20C
      WBPaper00064952:Day5_vs_L4_upregulated_25C
      WBPaper00064952:Day10_vs_Day1_upregulated_20C
      WBPaper00064952:Day10_vs_Day1_upregulated_25C
      WBPaper00064952:Day10_vs_L4_upregulated_20C
      WBPaper00064952:Day10_vs_L4_upregulated_25C
      WBPaper00064992:Capsaicin_downregulated
      WBPaper00064992:Eugenol_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065158:25C_vs_15C_upregulated_AFD
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065841:11_1
      WBPaper00065841:11_3
      WBPaper00065841:30_0
      WBPaper00065841:34_0
      WBPaper00065841:37_0
      WBPaper00065841:64_0
      WBPaper00065841:141_0
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066118:cyclobutrifluram_downregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00032948:FedUp
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036286:Pattern_I
      WBPaper00037695:LD_3-day
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040184:hcf-1down_sir-2.1down_daf-2up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045263:ProLongevity-mtROS_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00047070:DAF-16-dependent_UV_response
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:N2_UV_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00050515:nipi-3(fr4)_upregulated
      WBPaper00053550:daf-19(m86)_downregulated_AdultDay2
      WBPaper00055899:nitroguanidine_regulated
      [cgc6390]:intrinsic
    Interaction: WBInteraction000028927
      WBInteraction000113565
      WBInteraction000126522
      WBInteraction000126583
      WBInteraction000195723
      WBInteraction000203295
      WBInteraction000203471
      WBInteraction000220393
      WBInteraction000226548
      WBInteraction000246276
      WBInteraction000257449
      WBInteraction000259788
      WBInteraction000259789
      WBInteraction000259790
      WBInteraction000259791
      WBInteraction000259792
      WBInteraction000271409
      WBInteraction000297974
      WBInteraction000301451
      WBInteraction000303792
      WBInteraction000303793
      WBInteraction000303794
      WBInteraction000303795
      WBInteraction000325730
      WBInteraction000328441
      WBInteraction000332746
      WBInteraction000352704
      WBInteraction000352973
      WBInteraction000369940
      WBInteraction000378997
      WBInteraction000384241
      WBInteraction000425643
      WBInteraction000428275
      WBInteraction000435101
      WBInteraction000435569
      WBInteraction000435893
      WBInteraction000449363
      WBInteraction000465002
      WBInteraction000514740
      WBInteraction000514745
      WBInteraction000514746
      WBInteraction000540102
      WBInteraction000551486
      WBInteraction000564092
      WBInteraction000576330
  Map_info: Map: III Position: -3.17322 Error: 0.000158
    Positive: Positive_clone: C28A5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5582
        4211
    Pseudo_map_position
  Reference (11)
  Remark: III -3.7
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene