| WBGene00003417 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | Y41C4A |
| Identity | Version | 1 |
| | Name | CGC_name | mrt-2 | Person_evidence | WBPerson261 |
| | | Sequence_name | Y41C4A.14 |
| | | Molecular_name | Y41C4A.14 |
| | | | Y41C4A.14.1 |
| | | | CE29376 |
| | | | Y41C4A.14.2 |
| | | Other_name | hpr-1 |
| | | | CELE_Y41C4A.14 | Accession_evidence | NDB | BX284603 |
| | | Public_name | mrt-2 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mrt |
| | Allele (132) |
| | Strain | WBStrain00031909 |
| | | WBStrain00004639 |
| | RNASeq_FPKM (74) |
| | GO_annotation (26) |
| | Ortholog (34) |
| | Structured_description | Concise_description | mrt-2 encodes a highly conserved DNA-damage checkpoint protein homologous to the RAD1 protein found in S. pombe, Drosophila, and mammals; mrt-2 functions in the germline to maintain chromosomal integrity, and promote cell cycle arrest in mitotic germ cells and apoptosis in meiotic germ cells in response to genotoxic agents (DNA damage); mrt-2 mutations result in progressive telomere loss, chromosome fusion, and aneuploidy, eventually leading to germline mortality; MRT-2 interacts with HUS-1 and HPR-9, also conserved DNA-damage checkpoint proteins. | Paper_evidence | WBPaper00003353 |
| | | | | | WBPaper00003886 |
| | | | | | WBPaper00003984 |
| | | | | | WBPaper00005237 |
| | | | | | WBPaper00005597 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 14 Jun 2011 00:00:00 |
| | | Automated_description | Predicted to enable 3'-5' exonuclease activity and damaged DNA binding activity. Involved in DNA damage response and telomere maintenance via telomerase. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Is an ortholog of human RAD1 (RAD1 checkpoint DNA exonuclease). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | Y41C4A.14 |
| | Corresponding_transcript | Y41C4A.14.1 |
| | | Y41C4A.14.2 |
| | Other_sequence | JI459899.1 |
| | | CBC00612_1 |
| | | CR07641 |
| | | HG06632 |
| | | EY472449.1 |
| | | GP01754 |
| | | OF00726 |
| | | GE638976.1 |
| | | HCC04778_1 |
| | | MA03330 |
| | Associated_feature | WBsf994482 |
| | | WBsf225855 |
| Experimental_info | RNAi_result | WBRNAi00064153 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00022481 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00006768 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00064152 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00067556 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00064105 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00056356 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027845 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1016257 |
| | | Expr1031584 |
| | | Expr1159841 |
| | | Expr2013762 |
| | | Expr2031997 |
| | Drives_construct | WBCnstr00005145 |
| | Construct_product | WBCnstr00005145 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040560:hpl-2_embryo_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:daf-2(e1370)_downregulated_neuron |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_6 |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_fed-L1_Truseq |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00059566:P.luminescens_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061340:URX |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061527:kle-2_4298-vrk-1 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066038:mip-1(how5)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00025032:cluster_4 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030985:Photorhabdus_luminescens_downregulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_5 |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035479:daf-16(RNAi)_upregulated |
| | | WBPaper00035560:ahr-1_downregulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_3 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | Interaction | WBInteraction000001040 |
| | | WBInteraction000002294 |
| | | WBInteraction000002775 |
| | | WBInteraction000002906 |
| | | WBInteraction000003837 |
| | | WBInteraction000007010 |
| | | WBInteraction000008923 |
| | | WBInteraction000009734 |
| | | WBInteraction000009741 |
| | | WBInteraction000028493 |
| | | WBInteraction000029178 |
| | | WBInteraction000029180 |
| | | WBInteraction000029640 |
| | | WBInteraction000029641 |
| | | WBInteraction000029642 |
| | | WBInteraction000029745 |
| | | WBInteraction000029785 |
| | | WBInteraction000029786 |
| | | WBInteraction000029787 |
| | | WBInteraction000030086 |
| | | WBInteraction000030206 |
| | | WBInteraction000030797 |
| | | WBInteraction000031282 |
| | | WBInteraction000031283 |
| | | WBInteraction000031284 |
| | | WBInteraction000031285 |
| | | WBInteraction000031286 |
| | | WBInteraction000031287 |
| | | WBInteraction000031288 |
| | | WBInteraction000031289 |
| | | WBInteraction000031290 |
| | | WBInteraction000031291 |
| | | WBInteraction000031292 |
| | | WBInteraction000031293 |
| | | WBInteraction000031294 |
| | | WBInteraction000031295 |
| | | WBInteraction000031296 |
| | | WBInteraction000031297 |
| | | WBInteraction000031298 |
| | | WBInteraction000031300 |
| | | WBInteraction000031301 |
| | | WBInteraction000031302 |
| | | WBInteraction000031304 |
| | | WBInteraction000031306 |
| | | WBInteraction000031307 |
| | | WBInteraction000031308 |
| | | WBInteraction000031309 |
| | | WBInteraction000031310 |
| | | WBInteraction000051783 |
| | | WBInteraction000051785 |
| | | WBInteraction000052611 |
| | | WBInteraction000052612 |
| | | WBInteraction000109066 |
| | | WBInteraction000109195 |
| | | WBInteraction000115347 |
| | | WBInteraction000125393 |
| | | WBInteraction000125395 |
| | | WBInteraction000125397 |
| | | WBInteraction000125485 |
| | | WBInteraction000126969 |
| | | WBInteraction000132253 |
| | | WBInteraction000132628 |
| | | WBInteraction000132757 |
| | | WBInteraction000138817 |
| | | WBInteraction000139065 |
| | | WBInteraction000142729 |
| | | WBInteraction000153560 |
| | | WBInteraction000157344 |
| | | WBInteraction000165549 |
| | | WBInteraction000166131 |
| | | WBInteraction000168304 |
| | | WBInteraction000173501 |
| | | WBInteraction000183550 |
| | | WBInteraction000191256 |
| | | WBInteraction000204330 |
| | | WBInteraction000217892 |
| | | WBInteraction000217899 |
| | | WBInteraction000217945 |
| | | WBInteraction000218006 |
| | | WBInteraction000218040 |
| | | WBInteraction000218054 |
| | | WBInteraction000218057 |
| | | WBInteraction000218058 |
| | | WBInteraction000218198 |
| | | WBInteraction000218208 |
| | | WBInteraction000218234 |
| | | WBInteraction000220017 |
| | | WBInteraction000241003 |
| | | WBInteraction000248614 |
| | | WBInteraction000262623 |
| | | WBInteraction000266998 |
| | | WBInteraction000273777 |
| | | WBInteraction000275533 |
| | | WBInteraction000276301 |
| | | WBInteraction000282145 |
| | | WBInteraction000312604 |
| | | WBInteraction000348865 |
| | | WBInteraction000355534 |
| | | WBInteraction000370701 |
| | | WBInteraction000373297 |
| | | WBInteraction000376018 |
| | | WBInteraction000384240 |
| | | WBInteraction000384310 |
| | | WBInteraction000384503 |
| | | WBInteraction000389998 |
| | | WBInteraction000409932 |
| | | WBInteraction000410153 |
| | | WBInteraction000416834 |
| | | WBInteraction000426965 |
| | | WBInteraction000431258 |
| | | WBInteraction000439708 |
| | | WBInteraction000440983 |
| | | WBInteraction000441133 |
| | | WBInteraction000458737 |
| | | WBInteraction000501814 |
| | | WBInteraction000507927 |
| | | WBInteraction000509418 |
| | | WBInteraction000509419 |
| | | WBInteraction000509772 |
| | | WBInteraction000509777 |
| | | WBInteraction000509781 |
| | | WBInteraction000509785 |
| | | WBInteraction000509790 |
| | | WBInteraction000509792 |
| | | WBInteraction000509800 |
| | | WBInteraction000509808 |
| | | WBInteraction000509809 |
| | | WBInteraction000513228 |
| | | WBInteraction000514235 |
| | | WBInteraction000514236 |
| | | WBInteraction000514239 |
| | | WBInteraction000514240 |
| | | WBInteraction000514241 |
| | | WBInteraction000514242 |
| | | WBInteraction000514243 |
| | | WBInteraction000514244 |
| | | WBInteraction000514245 |
| | | WBInteraction000514247 |
| | | WBInteraction000514248 |
| | | WBInteraction000514249 |
| | | WBInteraction000514250 |
| | | WBInteraction000515883 |
| | | WBInteraction000515884 |
| | | WBInteraction000520835 |
| | | WBInteraction000521796 |
| | | WBInteraction000523992 |
| | | WBInteraction000539471 |
| | | WBInteraction000539831 |
| | | WBInteraction000539832 |
| | | WBInteraction000539833 |
| | | WBInteraction000539834 |
| | | WBInteraction000539835 |
| | | WBInteraction000539836 |
| | | WBInteraction000539837 |
| | | WBInteraction000539838 |
| | | WBInteraction000539839 |
| | | WBInteraction000539840 |
| | | WBInteraction000539841 |
| | | WBInteraction000539842 |
| | | WBInteraction000539843 |
| | | WBInteraction000539844 |
| | | WBInteraction000539845 |
| | | WBInteraction000539846 |
| | | WBInteraction000539849 |
| | | WBInteraction000539855 |
| | | WBInteraction000539880 |
| | | WBInteraction000539929 |
| | | WBInteraction000539930 |
| | | WBInteraction000539936 |
| | | WBInteraction000541136 |
| | | WBInteraction000548361 |
| | | WBInteraction000548398 |
| | | WBInteraction000550932 |
| | | WBInteraction000550934 |
| | | WBInteraction000550935 |
| | | WBInteraction000550936 |
| | | WBInteraction000550937 |
| | | WBInteraction000550938 |
| | | WBInteraction000550939 |
| | | WBInteraction000550940 |
| | | WBInteraction000550941 |
| | | WBInteraction000550942 |
| | | WBInteraction000550943 |
| | | WBInteraction000550944 |
| | | WBInteraction000550945 |
| | | WBInteraction000550946 |
| | | WBInteraction000550947 |
| | | WBInteraction000550948 |
| | | WBInteraction000550949 |
| | | WBInteraction000550950 |
| | | WBInteraction000550955 |
| | | WBInteraction000550992 |
| | | WBInteraction000556226 |
| | | WBInteraction000556378 |
| | | WBInteraction000558085 |
| | | WBInteraction000558086 |
| | | WBInteraction000558087 |
| | WBProcess | WBbiopr:00000014 |
| | | WBbiopr:00000091 |
| Map_info | Map | III | Position | 12.0743 | Error | 0.051368 |
| | Positive | Positive_clone | Y41C4A | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4239 |
| | | | 4497 |
| | Pseudo_map_position |
| Reference (76) |
| Picture | WBPicture0000013091 |
| Remark | Sequence connection from [Ahmed S, Hodgkin J] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
