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WormBase Tree Display for Gene: WBGene00003639

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Name Class

WBGene00003639EvidencePaper_evidenceWBPaper00003416
SMapS_parentSequenceK10C3
IdentityVersion1
NameCGC_namenhr-49Person_evidenceWBPerson600
Sequence_nameK10C3.6
Molecular_name (17)
Other_nameCELE_K10C3.6Accession_evidenceNDBBX284601
Public_namenhr-49
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnhr
Allele (78)
StrainWBStrain00031166
WBStrain00031167
WBStrain00031172
WBStrain00032408
WBStrain00034504
WBStrain00036136
WBStrain00040338
WBStrain00049816
WBStrain00051874
WBStrain00052029
RNASeq_FPKM (74)
GO_annotation00008300
00008301
00008302
00008303
00008304
00008305
00008306
00008307
00034920
00034921
00034922
00034923
00034924
00034925
00034926
00034927
00034928
00034929
00034930
00034931
00034932
00034933
00034934
00034935
00034936
00034937
00034938
00034939
00034940
00034941
00034942
00034943
00034944
00034945
00034946
00034947
00034948
00034949
00034950
00034951
00111362
00111363
00111364
00111365
Contained_in_operonCEOP1566
Ortholog (37)
Paralog (42)
Structured_descriptionConcise_descriptionnhr-49 encodes a nuclear hormone receptor (NHR) related to the mammalian HNF4 (hepatocyte nuclear factor 4) family of NHRs; nhr-49 functions as a key regulator of fat metabolism and lifespan by regulating induction of beta-oxidation genes upon food deprivation and activation of stearoyl-CoA desaturase in fed animals, respectively; NHR-49 activates transcription in conjunction with the MDT-15 mediator subunit with which it physically interacts.Paper_evidenceWBPaper00003416
WBPaper00005655
WBPaper00024532
WBPaper00025114
WBPaper00026800
WBPaper00027365
Curator_confirmedWBPerson1843
Date_last_updated17 Mar 2009 00:00:00
Automated_descriptionPredicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in determination of adult lifespan; positive regulation of transcription from RNA polymerase II promoter in response to stress; and regulation of fatty acid metabolic process. Located in cytoplasm and nucleus. Expressed in hypodermis; intestinal cell; intestine; muscle cell; and neurons. Used to study alcohol use disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 4; glucose metabolism disease (multiple); and liver disease (multiple). Is an ortholog of human HNF4A (hepatocyte nuclear factor 4 alpha).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1574Homo sapiensPaper_evidenceWBPaper00041098
Curator_confirmedWBPerson324
Date_last_updated06 Jun 2019 00:00:00
DOID:9970Homo sapiensPaper_evidenceWBPaper00025114
Curator_confirmedWBPerson324
Date_last_updated20 Sep 2018 00:00:00
Potential_modelDOID:0111099Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:13809Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:9993Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:1686Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:5082Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
DOID:0080760Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5024)
Models_disease_assertedWBDOannot00000610
WBDOannot00000707
WBDOannot00000708
Molecular_infoCorresponding_CDSK10C3.6a
K10C3.6b
K10C3.6c
K10C3.6d
K10C3.6e
Corresponding_transcriptK10C3.6a.1
K10C3.6a.2
K10C3.6b.1
K10C3.6b.2
K10C3.6c.1
K10C3.6d.1
K10C3.6e.1
Other_sequence (69)
Associated_feature (15)
Transcription_factorWBTranscriptionFactor000564
Experimental_infoRNAi_result (49)
Expr_patternExpr9486
Expr10378
Expr12144
Expr16231
Expr1021226
Expr1031683
Expr1154213
Expr2014198
Expr2032439
Drives_constructWBCnstr00015289
WBCnstr00020172
WBCnstr00035977
Construct_productWBCnstr00014051
WBCnstr00016239
WBCnstr00020172
WBCnstr00021645
WBCnstr00021647
WBCnstr00035977
Regulate_expr_clusterWBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
WBPaper00061530:nhr-49(e2144)_downregulated
WBPaper00061530:nhr-49(e2144)_upregulated
Microarray_results (39)
Expression_clusterWBPaper00032528:L3_enriched
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038289:oocyte_protein
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00040221:DAF-12_target_ALF4
WBPaper00041222:unc-120(st364)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00045316:prg-1_upregulated_L4
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Oogenic
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050182:lmn-1(L535P)_upregulated
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051245:nucleus_specific
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053615:SMO-1_target
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055648:germline_expressed
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00057288:iff-1(RNAi)_upregulated_transcript
WBPaper00058691:CFP-1_interacting_protein
WBPaper00058691:set-2(bn129)_downregulated
WBPaper00058691:WDR-5.1_interacting_protein
WBPaper00058725:sftb-1(cer39)_downregulated
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00059763:neuron_expressed
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061340:CEPso
WBPaper00061340:g1A_g1P
WBPaper00061340:g1A_parent
WBPaper00061340:ILsh_OLLsh_OLQsh
WBPaper00061340:ILso
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061479:HDA-1_interacting_protein
WBPaper00061527:ldb-1_2877-scd-1_3086
WBPaper00061527:pkn-1_20439-tbc-12_11015
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062590:Aging_downregulated_hypodermis
WBPaper00064071:NHR-49_interacting
WBPaper00064565:dyf-1(mn335)_regulated_protein
WBPaper00064716:paraquat_upregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065158:AFD_depleted
WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
cgc4386_cluster_5_2
WBPaper00025032:cluster_189
WBPaper00025141:N2_Expressed_Genes
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00034739:N2moreDR1350
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035905:FBF-1_Associated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-exposed_3h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:cluster_91
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(41_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
SAGE_tag (12)
Interaction (374)
WBProcessWBbiopr:00000001
WBbiopr:00000121
Map_infoMapIPosition3.96404Error0.005389
PositivePositive_cloneK10C3Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5149
4447
Pseudo_map_position
Reference (157)
PictureWBPicture0000013096
WBPicture0000013097
WBPicture0000013098
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene