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WormBase Tree Display for Gene: WBGene00002050

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Name Class

WBGene00002050SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_nameifa-1Person_evidenceWBPerson105
WBPerson293
Sequence_nameF38B2.1
Molecular_name (15)
Other_nameCel IF A1Accession_evidenceEMBLX70834
CelIF a1
A1Paper_evidenceWBPaper00006137
CELE_F38B2.1Accession_evidenceNDBBX284606
Public_nameifa-1
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classifa
Allele (77)
StrainWBStrain00036052
RNASeq_FPKM (74)
GO_annotation00003708
00003709
00049423
00049424
00049425
00049426
00049427
00049428
00049429
00049430
00049431
00049432
00049433
00049434
Ortholog (65)
Paralog (12)
Structured_descriptionConcise_descriptionIFA-1 encodes an essential intermediate filament protein that is coexpressed with the essential IF protein IFB-1; IFA-1 is required for survival past the L1 larva stage, and a normal intestine; IFA-1 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFB-1; IFA-1 is predicted to function as a structural component of the cytoskeleton, and is required for larval development and normal intestinal morphology; ifa-1 is expressed in amphid sensory neurons, in tail neurons and other unidentified neurons, some pharyngeal muscles, the pharyngeal-intestinal valve, the vulva, and the rectum.Paper_evidenceWBPaper00001981
WBPaper00004761
WBPaper00006137
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to be a structural constituent of cytoskeleton. Predicted to be involved in cellular localization; heterochromatin formation; and nucleus organization. Located in intermediate filament. Expressed in several structures, including egg-laying apparatus; excretory cell; neurons; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Is an ortholog of human LMNB2 (lamin B2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111450Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6638)
DOID:0070296Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6638)
DOID:0080299Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6638)
Molecular_infoCorresponding_CDSF38B2.1a
F38B2.1b
F38B2.1c
F38B2.1d
F38B2.1e
Corresponding_CDS_historyF38B2.1:wp83
Corresponding_transcriptF38B2.1a.1
F38B2.1b.1
F38B2.1c.1
F38B2.1d.1
F38B2.1e.1
Other_sequenceHGC10904_1
AS02094
GR13420
ACC38236_1
AS13264
ACC18044_1
BF199444.1
JI170108.1
ES744665.1
FG619799.1
NBC02227_1
TDC02295_1
EX552993.1
EX501789.1
EW741518.1
BF199481.1
HG04134
JI477999.1
EY459048.1
TSC01166_1
FC542655.1
BUC01608_1
MIC00771_1
FC809782.1
Dviv_isotig09406
Tcol_isotig17280
ES564062.1
JO468053.1
MI04312
ES560553.1
AA901457.1
EX537287.1
EY458859.1
EY468815.1
HC00380
L31528.1
FC815711.1
MHC00695_1
EX558614.1
FK806690.1
ASC00083_1
EX544700.1
TSC02644_1
FC549150.1
Dviv_isotig09404
AW980259.1
MC03110
FC541246.1
FC815830.1
Tcol_isotig16103
FC545438.1
FF679843.1
Dviv_isotig09407
DI01806
L05918.1
ES566861.1
SR00472
AI077021.1
FC549309.1
EX547762.1
AI444854.1
Tcol_isotig03325
SS03039
ACC33908_1
FC548455.1
TMC00903_1
FC810424.1
ACC37373_1
FC543537.1
Acan_isotig19277
EX913138.1
JI463561.1
Tcol_isotig22963
AY154743.1
AS15940
EX547224.1
XIC03302_1
TVC00905_1
ES566869.1
ES410004.1
FG586032.1
ES565401.1
JI478685.1
FG974424.1
FG350827.1
TS03324
TM00759
FC554719.1
EX915577.1
FK801404.1
ES411938.1
EY464644.1
Acan_isotig07963
AS04187
EX543277.1
ES566067.1
CR08587
FE905597.1
MC00304
BMC04239_1
ACC10658_1
MJ03034
EX544903.1
Tcol_isotig03326
EW742658.1
MHC01452_1
OVC00810_1
Dviv_isotig09405
FC548301.1
EY472255.1
JI178827.1
EX547260.1
SRC00569_1
SR01832
EY458365.1
FK808737.1
Tcol_isotig03324
M95554.1
EX557139.1
FC548780.1
HBC10473_1
FG350352.1
EY468486.1
FG585767.1
EX561657.1
Dviv_isotig09402
FK808706.1
HG09315
FG586785.1
EX008556.1
HBC28321_1
EX560716.1
ASC06658_1
JI182189.1
BF199432.1
X68557.1
GO252174.1
MJC02043_1
FF679527.1
MHC00544_1
OVC01728_1
CRC11150_1
AI815264.1
AYC02365_1
ACC20929_1
AS02442
BU586281.1
Acan_isotig17453
JI472553.1
BMC05333_1
FC546348.1
ACC08746_1
TMC00671_1
GP03374
Hbac_isotig01117
JI219185.1
AE03590
EX566430.1
GP01179
EY458766.1
AI670483.1
EX564581.1
FC554643.1
BE636422.1
EX547475.1
MH07820
MI02698
CRC11623_1
BM174335.1
ACC10231_1
FC544162.1
BM277502.1
EX559612.1
MH00413
TS00612
SS03045
PPC05466_1
FC547715.1
X68558.1
MI01001
AF237484.1
JI464182.1
EX543228.1
CJC05051_1
FG350074.1
FE908279.1
FC546280.1
L23872.1
AYC03679_1
X86089.1
AA917260.1
AI665775.1
GPC02728_1
SRC02131_1
DIC01027_1
JI165647.1
FC547131.1
EY459518.1
MCC01169_1
ASC13182_1
FK807306.1
HCC00374_1
BMC00640_1
ES273159.1
MI02699
FK801401.1
Tcir_isotig20838
AS02280
XI02635
Hbac_isotig00255
EX501370.1
BF824665.1
Tcir_isotig09331
EX009715.1
ES561904.1
JO475139.1
JI168653.1
AI444905.1
BG734386.1
ACC10353_1
JI473865.1
AE00177
EX552712.1
GRC01567_1
Tcol_isotig15186
Oden_isotig19073
SSC02210_1
S77073.1
ES566095.1
AI317899.1
MH01980
FG580130.1
TSC00225_1
HBC07194_1
TM01295
ES410754.1
GPC00629_1
JI173978.1
FE908860.1
Dviv_isotig09403
EX015282.1
Associated_feature (14)
Experimental_infoRNAi_result (48)
Expr_patternExpr1495
Expr2762
Expr1013956
Expr1031203
Expr1150559
Expr2012676
Expr2030912
Drives_constructWBCnstr00010937
WBCnstr00036494
Construct_productWBCnstr00010937
WBCnstr00036494
Microarray_results (39)
Expression_clusterWBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00035269:cde-1_regulated
WBPaper00037047:aging_accelerated_insoluble_protein
WBPaper00037047:insoluble_protein
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038168:lin-15B(n744)_upregulated
WBPaper00038289:oocyte_protein
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00044037:eat-2_upregulated
WBPaper00044260:1-methylnicotinamide_upregulated
WBPaper00044260:nicotinc-acid_upregulated
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_upregulated
WBPaper00044736:oscillating_dev_expression
WBPaper00045417:128Q-huntingtin_downreglated
WBPaper00045521:Gender_Neutral
WBPaper00046121:ecdoderm_unique
WBPaper00046446:rapid-synthesized_AgingAdult
WBPaper00046497:B.thuringiensis_upregulated_protein
WBPaper00046509:htz-1(ok3099)_downregulated
WBPaper00046509:lin-35(n745)_downregulated
WBPaper00046858:elt-2(RNAi)_downregulated
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048785:heat-shock_upregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049159:Microwave_upregulated_adult
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049942:HeatShock_upregulated_hsf-1(+)
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
WBPaper00050344:AFD-neuron_enriched
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050636:aging_regulated_insoluble_protein
WBPaper00050686:glp-1(e2141)_upregulated
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:pharynx_expressed
WBPaper00051245:cytoplasm_specific
WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
WBPaper00051245:pharyngeal-muscle_specific
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:stavudine_72h_regulated
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053318:Aging_downregulated_mRNA_N2
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00053599:female_vs_male_downregulated
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
WBPaper00053615:SMO-1_target
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00053814:15C_downregulated_PY79
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Psora_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin-Psora_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055386:eat-2(ad465)_upregulated
WBPaper00055482:Tunicamycin_downregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055648:anterior-head_expressed
WBPaper00055648:pharynx_expressed
WBPaper00055648:vulva-uterus_expressed
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055897:heat-shock_upregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
WBPaper00056275:P.aeruginosa_upregulated
WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056900:ERH-2_interacting
WBPaper00056900:PID-3_interacting
WBPaper00056900:TOFU-6_interacting
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058691:set-2(bn129)_upregulated
WBPaper00058711:paraquat_upregulated
WBPaper00058725:sftb-1(cer6)_downregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059728:20ug_cholesterol_upregulated
WBPaper00059754:C.neoformans_H99_upregulated
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059987:Wounding_upregulated
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:AMsh
WBPaper00061340:AMso
WBPaper00061340:Arcade_cell_anterior_and_posterior
WBPaper00061340:CEPsh
WBPaper00061340:Excretory_gland
WBPaper00061340:ILsh_OLLsh_OLQsh
WBPaper00061340:mc2
WBPaper00061340:Posterior_arcade_cell
WBPaper00061341:28C_48h_downregulated
WBPaper00061377:MYRF-2_interacting
WBPaper00061377:PAN-1_interacting
WBPaper00061527:saeg-1_18803-mpz-2_15880
WBPaper00061651:AMso_enriched
WBPaper00061651:CEPsh_enriched
WBPaper00061651:PHsh_enriched
WBPaper00061818:AFD_enriched_protein
WBPaper00061818:ELKS-1_interacting
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:daf-16(RNAi)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062554:MAGU-2_interacting
WBPaper00062590:Aging_downregulated_neuron
WBPaper00064005:starvation_downregulated_N2_mRNA
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064532:pals-25(icb98)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064721:fasn-1(g14)_downregulated_starved
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064789:Day9_vs_Day1_upregulated_neuron
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
WBPaper00065841:26_1
WBPaper00065841:30_1
WBPaper00065841:37_0
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066038:mip-1(how5)_upregulated
WBPaper00066110:Cisplatin_upregulated_diploid
WBPaper00066110:Doxorubicin_upregulated_diploid
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
WBPaper00025141:N2_Expressed_Genes
WBPaper00027342:alpha-Synuclein(WT)_upregulated
WBPaper00029437:dcr-1_upregulated
WBPaper00030985:Serratia_marcesens_upregulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00032062:age_regulated_genes
WBPaper00032948:FedUp
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00036123:Cadmium_regulated
WBPaper00037695:LD_3-day
WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_old
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041906:I-3690_vs_OP50_3d
WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
WBPaper00042258:DA1877_upregulated_GravidAdult
WBPaper00045960:L1-L4-lethargus_upregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00047070:N2_UV_upregulated
WBPaper00048624:hlh-25(ok1710)_upregulated
WBPaper00048989:N2_allantoin_downregulated
[cgc6390]:Cluster_C
Interaction (72)
Map_infoMapXPosition2.86537Error0.001386
PositivePositive_cloneF38B2Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4945
4421
4442
Pseudo_map_position
Reference (14)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene