WormBase Tree Display for Gene: WBGene00003003
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WBGene00003003 | SMap | S_parent | Sequence | T25C12 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | lin-14 | Person_evidence | WBPerson261 | |||||
Sequence_name | T25C12.1 | ||||||||
Molecular_name | T25C12.1a | ||||||||
T25C12.1a.1 | |||||||||
CE43285 | |||||||||
T25C12.1b | |||||||||
CE03734 | |||||||||
T25C12.1b.1 | |||||||||
Other_name | CELE_T25C12.1 | Accession_evidence | NDB | BX284606 | |||||
Public_name | lin-14 | ||||||||
DB_info | Database | AceView | gene | XM103 | |||||
WormQTL | gene | WBGene00003003 | |||||||
WormFlux | gene | WBGene00003003 | |||||||
NDB | locus_tag | CELE_T25C12.1 | |||||||
NCBI | gene | 181337 | |||||||
RefSeq | protein | NM_077515.5 | |||||||
NM_077516.7 | |||||||||
SwissProt | UniProtAcc | Q21446 | |||||||
TREEFAM | TREEFAM_ID | TF316913 | |||||||
UniProt_GCRP | UniProtAcc | Q21446 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lin | ||||||||
Reference_allele | WBVar00089301 | ||||||||
WBVar00089587 | |||||||||
Allele (337) | |||||||||
Legacy_information | Class 1 alleles (loss-of-function) n526n540ird : precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva endoderm and mesoderm; abnormal cuticle formation; ES2; male more severely affected only three molts gonadal development abnormal. Similar phenotype in n536n540/Df. NA > 10 (n179ts etc.; also Class 1a n355n679ird ts (only early events precocious); Class 1b n360ts (only late events precocious). Class 2 alleles (gain-of-function) n536sd : retarded heterochronic alterations in many lineages abnormal vulval development cuticle formation supernumerary molts extra divisions in sex mesoblasts intestine etc.; gonadal lineages normal. ES3. ME0? NA2 (n355sd). For both Class 1 and Class 2 mutations late lineages are less affected if animal develops via dauer stage. | ||||||||
See also n179, n355, n360, n407, n530, n531, n532, n534, n535, n536, n539, n540, n679, n726, n727, n837, n838, n839, n840, n841, n842 | |||||||||
[C.elegansII] n526n540ird : lf allele (Class II, a-b-), precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva,endoderm and mesoderm; abnormal cuticle formation; precocious dauer entry at L1 molt; ES2; male more severely affected, only three molts, gonadal development abnormal. Similar phenotype in n536n540/Df. OA>10: n179ts, etc.; also n355n679ird,ts (Class V, a-b+, only early events precocious); n360ts(Class III, a+b-, only late events precocious). Also gain-of-function alleles: n536sd (Class I, retarded heterochronic alterations in many lineages; abnormal vulval development, cuticle formation, supernumerary molts, extra divisions in sex mesoblasts, intestine etc.; gonadal lineages normal. ES3), n355sd(similar). Numerous intragenic revertants. For both lf and gf mutations, late lineages are less affected if animal develops via dauer stage. Cloned: two 3.5 kb transcripts, differing 5',encoding 70 kD novel proteins; antibodies stain nuclei; protein levels high in L1, reduced or absent later. Gain-of-function mutations affect3' UTR. [Ruvkun and Giusto 1989; Wightman et al. 1993; GR; VT] | |||||||||
Strain (20) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (16) | |||||||||
Ortholog (28) | |||||||||
Structured_description | Concise_description | lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. | Paper_evidence | WBPaper00000620 | |||||
WBPaper00001137 | |||||||||
WBPaper00001468 | |||||||||
WBPaper00001829 | |||||||||
WBPaper00001848 | |||||||||
WBPaper00003931 | |||||||||
WBPaper00005159 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 02 Sep 2005 00:00:00 | ||||||||
Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | T25C12.1a | |||||||
T25C12.1b | |||||||||
Corresponding_CDS_history | T25C12.1a:wp196 | ||||||||
Corresponding_transcript | T25C12.1a.1 | ||||||||
T25C12.1b.1 | |||||||||
Other_sequence (11) | |||||||||
Associated_feature (55) | |||||||||
Transcription_factor | WBTranscriptionFactor000395 | ||||||||
Experimental_info | RNAi_result (17) | ||||||||
Expr_pattern | Expr660 | ||||||||
Expr661 | |||||||||
Expr2427 | |||||||||
Expr3844 | |||||||||
Expr10058 | |||||||||
Expr10078 | |||||||||
Expr13436 | |||||||||
Expr16159 | |||||||||
Expr1021607 | |||||||||
Expr1031400 | |||||||||
Expr1157659 | |||||||||
Expr2013160 | |||||||||
Expr2031392 | |||||||||
Drives_construct | WBCnstr00000926 | ||||||||
WBCnstr00007336 | |||||||||
WBCnstr00007627 | |||||||||
WBCnstr00015030 | |||||||||
WBCnstr00015050 | |||||||||
WBCnstr00015780 | |||||||||
WBCnstr00015781 | |||||||||
WBCnstr00036292 | |||||||||
Construct_product | WBCnstr00000967 | ||||||||
WBCnstr00007627 | |||||||||
WBCnstr00019563 | |||||||||
WBCnstr00019564 | |||||||||
WBCnstr00021119 | |||||||||
WBCnstr00021910 | |||||||||
WBCnstr00036292 | |||||||||
Regulate_expr_cluster | WBPaper00026952:class_A | ||||||||
WBPaper00026952:class_B | |||||||||
WBPaper00026952:class_C | |||||||||
WBPaper00026952:class_D | |||||||||
WBPaper00026952:class_E | |||||||||
WBPaper00026952:class_F | |||||||||
WBPaper00026952:class_G | |||||||||
WBPaper00026952:class_H | |||||||||
Antibody (6) | |||||||||
Microarray_results (33) | |||||||||
Expression_cluster (173) | |||||||||
Interaction (256) | |||||||||
WBProcess | WBbiopr:00000031 | ||||||||
WBbiopr:00000057 | |||||||||
WBbiopr:00000083 | |||||||||
Map_info | Map | X | Position | 3.78431 | Error | 0.060767 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | nDf19 | |||||||
yDp8 | |||||||||
yDp10 | |||||||||
Positive_clone | PPE4 | ||||||||
T25C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Mapping_data | 2_point | 251 | |||||||
492 | |||||||||
636 | |||||||||
637 | |||||||||
688 | |||||||||
3648 | |||||||||
3652 | |||||||||
Multi_point (22) | |||||||||
Pos_neg_data | 3918 | ||||||||
3920 | |||||||||
654 | |||||||||
668 | |||||||||
3155 | |||||||||
294 | |||||||||
1831 | |||||||||
8427 | |||||||||
Reference (365) | |||||||||
Method | Gene |