WormBase Tree Display for Gene: WBGene00005023

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WBGene00005023	Evidence	Paper_evidence	WBPaper00005867
	SMap	S_parent	Sequence	T24D1
	Identity	Version	2
		Name	CGC_name	sqv-5	Person_evidence	WBPerson268
			Sequence_name	T24D1.1
			Molecular_name	T24D1.1a
				T24D1.1a.1
				CE50401
				T24D1.1b
				CE39182
				T24D1.1c
				CE50402
				T24D1.1b.1
				T24D1.1c.1
			Other_name	ChSy-S	Accession_evidence	EMBL	AB088398
				CELE_T24D1.1	Accession_evidence	NDB	BX284601
			Public_name	sqv-5
		DB_info	Database	AceView	gene	1K529
				WormQTL	gene	WBGene00005023
				WormFlux	gene	WBGene00005023
				NDB	locus_tag	CELE_T24D1.1
				Panther	gene	CAEEL\|WormBase=WBGene00005023\|UniProtKB=Q7Z1Z1
					family	PTHR12369
				NCBI	gene	172851
				RefSeq	protein	NM_001026468.8
						NM_001313510.4
						NM_001026469.8
				KEGG	KEGG_id	2.4.1.226
						2.4.1.-
				NemaPath	KEGG_id	2.4.1.226
						2.4.1.-
				SwissProt	UniProtAcc	Q7Z1Z1
				TrEMBL	UniProtAcc	A0A0K3ATP9
				UniProt_GCRP	UniProtAcc	Q7Z1Z1
				OMIM	gene	608183
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:37	WBPerson1971	Event	Imported	Initial conversion from geneace
				2	02 Mar 2018 11:09:16	WBPerson4025	Event	Split_into	WBGene00303082
			Split_into	WBGene00303082
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	sqv
		Allele (53)
		Legacy_information	[Herman T] sqv for squashed vulva. morphology of L4 vulva abnormal (invagination considerably reduced). hermaphrodites self-sterile.
			[C.elegansII] n3039 : morphology of L4 vulva abnormal (invagination considerably reduced); hermaphrodites self-sterile. [MT]
		Strain	WBStrain00027364
			WBStrain00027385
			WBStrain00028700
			WBStrain00028702
			WBStrain00007564
		RNASeq_FPKM (74)
		GO_annotation (21)
		Ortholog (44)
		Paralog	WBGene00003253	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
		Structured_description	Concise_description	sqv-5 encodes a chondroitin synthase that both initiates and elongates chondroitin chains (unlike human chondroitin synthase, which only elongates them); SQV-5 is required for cytokinesis (e.g., at the one-cell embryo stage), gonad migration, and vulval morphogenesis (by expanding the extracellular space of the vulva in L4 larvae); the common requirement for SQV-5 in both processes may be to promote filling an extracellular space with fluid (either in the eggshell, or underneath the L4 cuticle); SQV-5 colocalizes with SQV-1 at punctate foci (probably the Golgi apparatus) in the cytoplasm of the vulva, the uterus and oocytes; SQV-5 is most similar to human chondroitin synthase (KIAA0990) and Drosophila CG9220.	Paper_evidence	WBPaper00003405
						WBPaper00003736
						WBPaper00003906
						WBPaper00005540
						WBPaper00005867
						WBPaper00005868
						WBPaper00012887
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
			Automated_description	Enables enzyme binding activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and vulval development. Located in cytoplasm. Expressed in oocyte; uterus; and vulva. Human ortholog(s) of this gene implicated in temtamy preaxial brachydactyly syndrome. Is an ortholog of human CHSY1 (chondroitin sulfate synthase 1) and CHSY3 (chondroitin sulfate synthase 3).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model	DOID:0050814	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:17198)
	Molecular_info	Corresponding_CDS	T24D1.1a
			T24D1.1b
			T24D1.1c
		Corresponding_CDS_history	T24D1.1a:wp149
			T24D1.1a:wp246
			T24D1.1b:wp149
			T24D1.1d:wp264
		Corresponding_transcript	T24D1.1a.1
			T24D1.1b.1
			T24D1.1c.1
		Other_sequence (32)
		Associated_feature (14)
	Experimental_info	RNAi_result (14)
		Expr_pattern	Expr2566
			Expr3104
			Expr1023591
			Expr1032506
			Expr1157585
			Expr2016123
			Expr2034358
		Drives_construct	WBCnstr00018534
			WBCnstr00035261
		Construct_product	WBCnstr00018534
			WBCnstr00035261
		Antibody	WBAntibody00000621
			WBAntibody00001858
		Microarray_results (29)
		Expression_cluster	WBPaper00031040:TGF-beta_adult_downregulated
			WBPaper00036375:enriched_in_PVD_OLL
			WBPaper00037055:DAF-16_binding_DNA
			WBPaper00037950:coelomocytes_embryo_enriched
			WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched
			WBPaper00038118:aak-2(gt33)_upregulated
			WBPaper00044578:reduced-humidity_downregulated_microarray
			WBPaper00044656:tatn-1(qd182)_downregulated
			WBPaper00044736:flat_dev_expression
			WBPaper00044786:emr-1(gk119)_downregulated
			WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
			WBPaper00045050:csr-1(hypomorph)_downregulated
			WBPaper00045420:fertilization_downregulated_transcript
			WBPaper00045521:Oogenic
			WBPaper00045571:germline-ablation_downregulated
			WBPaper00045729:gld-2(RNAi)_downregulated
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
			WBPaper00046509:htz-1(ok3099)_upregulated
			WBPaper00048762:FOG-3_associated
			WBPaper00048988:neuron_expressed
			WBPaper00049498:npr-1(ur89)_regulated_3
			WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
			WBPaper00049920:Glucose-Diet_downregulated_N2
			WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
			WBPaper00049942:hsf-1(RNAi)_upregulated
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
			WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
			WBPaper00050522:mafr-1(tm6082)_downregulated
			WBPaper00050726:OsmoticStress_regulated_Food
			WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050990:body-muscle_expressed
			WBPaper00050990:hypodermis_expressed
			WBPaper00050990:NMDA-neuron_expressed
			WBPaper00051039:germline_enriched
			WBPaper00051265:F1_morc-1(tm6048)_downregulated
			WBPaper00051265:F4_hrde-1(tm1200)_upregulated
			WBPaper00051265:F4_morc-1(tm6048)_upregulated
			WBPaper00052884:emb-4(hc60)_downregulated
			WBPaper00053184:sma-2(rax5)_downregulated
			WBPaper00053184:sma-4(rax3)_downregulated
			WBPaper00053302:alovudine_24h_regulated
			WBPaper00053302:stavudine_24h_regulated
			WBPaper00053302:zidovudine_24h_regulated
			WBPaper00053302:zidovudine_72h_regulated
			WBPaper00053599:female_vs_male_upregulated
			WBPaper00053599:oocyte_vs_mitosis_downregulated
			WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
			WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
			WBPaper00054792:FOG-3_interacting
			WBPaper00055334:DLC-1_interacting
			WBPaper00055354:Rapamycin-Allantoin_upregulated
			WBPaper00055354:Rapamycin_upregulated
			WBPaper00055648:germline_expressed
			WBPaper00055971:nhl-2(ok818)_20C_upregulated
			WBPaper00055971:nhl-2(ok818)_25C_upregulated
			WBPaper00056034:pals-22(jy3)_downregulated
			WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
			WBPaper00056275:P.aeruginosa_upregulated
			WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
			WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
			WBPaper00056443:sek-1(km4)_downregulated
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
			WBPaper00056826:hmc_biased
			WBPaper00057154:HeatShock_downregulated_mRNA
			WBPaper00057288:iff-1(RNAi)_upregulated_transcript
			WBPaper00058598:sin-3(tm1276)_upregulated
			WBPaper00058691:set-2(bn129)_downregulated
			WBPaper00058691:sin-3(tm1276)_upregulated
			WBPaper00058948:PA14_upregulated
			WBPaper00059027:neuron-synapses_enriched
			WBPaper00059174:MEG-3_interacting
			WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
			WBPaper00059471:EGL-43_interacting
			WBPaper00059664:srbc-48(ac23)_downregulated
			WBPaper00059763:neuron_expressed
			WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
			WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
			WBPaper00060445:nfki-1(cer1)_upregulated_L4
			WBPaper00060459:bcat-1(RNAi)_downregulated
			WBPaper00060661:sensory-neuron_depleted
			WBPaper00060683:hlh-11(ko1)_downregulated
			WBPaper00060811:L1_vs_adult_downregulated_neural
			WBPaper00060909:atfs-1(cmh15)_upregulated
			WBPaper00061007:S.aquatilis_downregulated
			WBPaper00061203:sin-3(tm1276)_downregulated
			WBPaper00061203:spr-1(ok2144)_downregulated
			WBPaper00061274:hypergravity_15xg_upregulated
			WBPaper00061340:B
			WBPaper00061340:Coelomocyte
			WBPaper00061340:F_U
			WBPaper00061340:GLR
			WBPaper00061340:hmc
			WBPaper00061340:hmc_homolog
			WBPaper00061340:K_Kprime
			WBPaper00061340:Neuroblast_BAG_SMDVx
			WBPaper00061340:Parents_of_U_F_B_DVA
			WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V
			WBPaper00061340:Parent_of_hyp3_ILsoDx
			WBPaper00061340:Parent_of_tail_spike_and_hyp10
			WBPaper00061340:Z1_Z4
			WBPaper00061527:hrdl-1_3731-lst-4_2238
			WBPaper00061527:trcs-2_5724-R11A8.7_17645
			WBPaper00061753:csr-1(tor159)_downregulated_25C
			WBPaper00062159:hda-2(ok1479)_downregulated
			WBPaper00062325:muscle_enriched_coding-RNA
			WBPaper00062669:extracellular-vesicle_protein
			WBPaper00064071:NHR-49_interacting
			WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
			WBPaper00064502:spe-44(fx110)_upregulated
			WBPaper00064505:tamoxifen_upregulated
			WBPaper00064716:paraquat_upregulated
			WBPaper00064871:hypoxia_upregulated_F1
			WBPaper00065096:25C_vs_20C_upregulated
			WBPaper00065096:Day10_vs_Day1_upregulated
			WBPaper00065373:Cisplatin_upregulated_WT
			WBPaper00065373:sek-1(km4)_downregulated_cisplatin
			WBPaper00065993:glp-1(e2141)_downregulated
			WBPaper00066110:tetraploid_vs_diploid_downregulated
			WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
			cgc4489_group_2
			WBPaper00025032:cluster_6
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00025141:unc-4::GFP_Expressed_Genes
			WBPaper00026929:sir-2.1_overexpression_regulated
			WBPaper00030985:Enterococcus_faecalis_downregulated
			WBPaper00031252:AIN-1_IP_enriched
			WBPaper00031252:AIN-2_IP_enriched
			WBPaper00034739:N2lessDR1350
			WBPaper00035084:L4_enriched_AIN-2_IP
			WBPaper00035873:dpy-9_regulated
			WBPaper00035873:dpy-10_regulated
			WBPaper00035905:FBF-1_Associated
			WBPaper00036286:Pattern_F
			WBPaper00037147:heatshock_upregulated
			WBPaper00037611:GLD-2-associated
			WBPaper00037611:RNP-8-associated
			WBPaper00037901:GLD-1_mRNA_targets
			WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
			WBPaper00041002:HF_3d_2.0mM_Down
			WBPaper00041002:HF_11d_2.0mM_Up
			WBPaper00041002:HQ_3d_2.0mM_Down
			WBPaper00041606:CE_B.thuringiensis-DB27_regulated
			WBPaper00041606:CE_S.marcescens_regulated
			WBPaper00041606:CE_X.nematophila_regulated
			WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
			WBPaper00045263:0.1mM-paraquat_upregulated
			WBPaper00045263:nuo-6(qm200)_upregulated
			[cgc5376]:let-60(G12V)-regulated_genes
			[cgc5767]:cluster_1
			[cgc5767]:expression_class_M
			[cgc5767]:expression_class_MD
			[cgc5767]:expression_class_MD_pd(53_min)
			[cgc5767]:expression_class_SM
			[cgc5767]:expression_class_SMD
			[cgc6390]:Cluster_F
			[cgc6390]:oogenesis-enriched
		Interaction (66)
	Map_info	Map	I	Position	4.09354	Error	0.007416
		Positive	Positive_clone	T24D1	Inferred_automatically	From CDS info
						From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	3143
				3144
				5407
				5544
	Reference (32)
	Method	Gene