WormBase Tree Display for Gene: WBGene00001645

WBGene00001645 Evidence: Person_evidence: WBPerson2558
  SMap: S_parent: Sequence: C03E10
  Identity: Version: 1
    Name: CGC_name: gly-20 Person_evidence: WBPerson228
      Sequence_name: C03E10.4
      Molecular_name: C03E10.4
        C03E10.4.1
        CE26613
      Other_name: GnT II Paper_evidence: WBPaper00005572
        CELE_C03E10.4 Accession_evidence: NDB BX284605
      Public_name: gly-20
    DB_info: Database: AceView gene 5L765
        WormQTL gene WBGene00001645
        WormFlux gene WBGene00001645
        NDB locus_tag CELE_C03E10.4
        Panther gene CAEEL|WormBase=WBGene00001645|UniProtKB=O17560
          family PTHR12871
        NCBI gene 179562
        RefSeq protein NM_073463.9
        KEGG KEGG_id 2.4.1.143
        NemaPath KEGG_id 2.4.1.143
        TREEFAM TREEFAM_ID TF314772
        TrEMBL UniProtAcc O17560
        UniProt_GCRP UniProtAcc O17560
        OMIM gene 602616
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gly
    Allele (46)
    Strain: WBStrain00031654
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (38)
    Structured_description: Concise_description: gly-20 encodes an N-acetylglucosaminyltransferase II (GnTII); by homology, GLY-20 is predicted to function in the Golgi to effect protein N-glycosylation; expression of C. elegans GLY-20 and bovine beta1,4-galactosyltransferase I in a baculoviral insect cell system results in efficient glycosylation of mammalian proteins. Paper_evidence: WBPaper00040952
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 10 Apr 2012 00:00:00
      Automated_description: Predicted to enable alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. Involved in protein N-linked glycosylation. Predicted to be located in Golgi membrane. Used to study carbohydrate metabolic disorder. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIa. Is an ortholog of human MGAT2 (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:2978 Homo sapiens Paper_evidence: WBPaper00064167
          Curator_confirmed: WBPerson324
          Date_last_updated: 10 May 2023 00:00:00
    Potential_model: DOID:0070253 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7045)
  Models_disease_in_annotation: WBDOannot00000055
  Molecular_info: Corresponding_CDS: C03E10.4
    Corresponding_CDS_history: C03E10.4:wp31
    Corresponding_transcript: C03E10.4.1
    Other_sequence (34)
    Associated_feature: WBsf1001312
      WBsf232490
      WBsf232491
  Experimental_info: RNAi_result: WBRNAi00039526 Inferred_automatically: RNAi_primary
      WBRNAi00010055 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1028272
      Expr1030985
      Expr1143626
      Expr2012141
      Expr2030377
    Drives_construct: WBCnstr00036801
    Construct_product: WBCnstr00036801
    Microarray_results (22)
    Expression_cluster: WBPaper00030922:glycosylated_protein
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00054758:alg-2(ok304)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Metformin_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(et18)_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:AIY
      WBPaper00061340:GLR
      WBPaper00061340:Rectal_cell
      WBPaper00061340:RIH
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:lst-4_22151-F46F11.6_12556
      WBPaper00061800:miR-85(n4117)_upregulated_20C
      WBPaper00061800:miR-85(n4117)_upregulated_35C
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064505:tamoxifen_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00025032:cluster_4
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036286:Pattern_F
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00042548:miRISC_enriched
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_1
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(41_min)
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:Cluster_E
      [cgc6390]:intrinsic
    Interaction (31)
  Map_info: Map: V Position: 3.05492 Error: 0.002457
    Positive: Positive_clone: C03E10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4225
        4365
    Pseudo_map_position
  Reference (14)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene