| WBGene00000879 | SMap | S_parent | Sequence | Y75B12B |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | cyn-3 | Person_evidence | WBPerson466 |
| | | Sequence_name | Y75B12B.5 |
| | | Molecular_name | Y75B12B.5 |
| | | | Y75B12B.5.1 |
| | | | CE20374 |
| | | Other_name | cyp-3 | Person_evidence | WBPerson466 |
| | | | CELE_Y75B12B.5 | Accession_evidence | NDB | BX284605 |
| | | Public_name | cyn-3 |
| | DB_info | Database | AceView | gene | 5P671 |
| | | | WormQTL | gene | WBGene00000879 |
| | | | WormFlux | gene | WBGene00000879 |
| | | | NDB | locus_tag | CELE_Y75B12B.5 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00000879|UniProtKB=P52011 |
| | | | | family | PTHR11071 |
| | | | NCBI | gene | 180028 |
| | | | RefSeq | protein | NM_074350.9 |
| | | | KEGG | KEGG_id | 5.2.1.8 |
| | | | NemaPath | KEGG_id | 5.2.1.8 |
| | | | SwissProt | UniProtAcc | P52011 |
| | | | TREEFAM | TREEFAM_ID | TF312801 |
| | | | UniProt_GCRP | UniProtAcc | P52011 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 20 Sep 2004 16:20:03 | WBPerson1971 | Name_change | CGC_name | cyp-3 -> cyn-3 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cyn |
| | Allele (28) |
| | Legacy_information | [C.elegansII] NMK. Cyclophilin family, transspliced to SL1. YAC Y15F7. [TP] |
| | RNASeq_FPKM (74) |
| | GO_annotation (15) |
| | Contained_in_operon | CEOP5521 |
| | Ortholog (54) |
| | Paralog (18) |
| | Structured_description | Concise_description | cyn-3 encodes an abundantly expressed cyclophilin A isoform with peptidyl-prolyl isomerase activity in vitro, which closely resembles the prototypical CypA and is thus likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; cyn-3 is exclusively expressed in the single anterior excretory cell, and is dispensable for viability and gross morphology in mass RNAi screens. | Paper_evidence | WBPaper00002472 |
| | | | | | WBPaper00003820 |
| | | | | | WBPaper00005654 |
| | | | | | WBPaper00026884 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 20 Mar 2007 00:00:00 |
| | | Automated_description | Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in obsolete cell. Expressed in excretory system. Human ortholog(s) of this gene implicated in several diseases, including Bell's palsy; aggressive periodontitis; and gastrointestinal system cancer (multiple). Is an ortholog of human PPIA (peptidylprolyl isomerase A); PPIAL4C (peptidylprolyl isomerase A like 4C); and PPIF (peptidylprolyl isomerase F). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:4947 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) |
| | | DOID:9261 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) |
| | | DOID:1474 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) |
| | | DOID:526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) |
| | | DOID:12506 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) |
| Molecular_info | Corresponding_CDS | Y75B12B.5 |
| | Corresponding_transcript | Y75B12B.5.1 |
| | Other_sequence (202) |
| | Associated_feature | WBsf647585 |
| | | WBsf977375 |
| | | WBsf977376 |
| | | WBsf1002255 |
| | | WBsf1002256 |
| | | WBsf1020992 |
| | | WBsf233011 |
| Experimental_info | RNAi_result | WBRNAi00076847 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00021430 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00058423 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027819 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr984 |
| | | Expr985 |
| | | Expr1018223 |
| | | Expr1030544 |
| | | Expr1161844 |
| | | Expr2010671 |
| | | Expr2028911 |
| | Drives_construct | WBCnstr00013833 |
| | | WBCnstr00037227 |
| | Construct_product | WBCnstr00013833 |
| | | WBCnstr00037227 |
| | Microarray_results (23) |
| | Expression_cluster | WBPaper00028451:Oogenic_protein |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00037047:aging_accelerated_insoluble_protein |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00038061:aldicarb_upregulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq |
| | | WBPaper00043951:Nascent-polypeptide-associated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:lin-35(n745)_downregulated |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00049498:npr-1(ur89)_regulated_6 |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:body-wall-muscle_nucleus_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051265:F4_morc-1(tm6048)_downregulated |
| | | WBPaper00051555:atm-1(gk186)_regulated_protein |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053388:dauer_regulated_Cluster6 |
| | | WBPaper00055049:S.gordonii_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056900:PID-3_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(zr2012)_upregulated |
| | | WBPaper00060100:SiNP_downregulated_mRNA |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:dld-1-skn-1_16701 |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:IL2_LR_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00062056:dpl-1(n2994)_downregulated |
| | | WBPaper00062056:lin-35(n745)_downregulated |
| | | WBPaper00062056:lin-37(n758)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064107:lin-35(n745)_downregulated |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064257:UNG-1_interacting |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00066085:hda-3(ok1991)_downregulated |
| | | cgc4386_cluster_2_6 |
| | | cgc4489_group_3 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026629:L2_male_enriched |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00032948:FedUp |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00036375:depleted_in_PVD_OLL |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00048637:lin-35(n745)_starvation_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_14 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MDE |
| | | [cgc5767]:expression_class_MD_pd(23_min) |
| | | [cgc5767]:expression_class_ME |
| | Interaction (105) |
| Map_info | Map | V | Position | 7.54862 | Error | 0.006411 |
| | Positive | Positive_clone | Y15F7 | Author_evidence | Page AM |
| | | | Y75B12B | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | ZK526 |
| | Pseudo_map_position |
| Reference | WBPaper00002472 |
| | WBPaper00003820 |
| | WBPaper00018604 |
| | WBPaper00026884 |
| | WBPaper00032230 |
| | WBPaper00038491 |
| | WBPaper00041771 |
| | WBPaper00049828 |
| | WBPaper00055090 |
| Remark | [Page AM] Is transpliced by SL-1. Isolated from mixed stage cDNA by A. P. Page using SL1, and known 3' seq from CEESH95F. (not mapped); Genbank U31077. |
| | [JAH]Partial sequence identity 64% to human CYP gene, 66% to yeast CSBY. |
| | CEESH95F,CEMSB85F,CEMSB85FB,CEMSB85R removed from sequence list and replaced by genomic_canonical Y75B12B.5. sdm 11/00 |
| | PPIase or cyclophilin, EC 5.2.1.8 |
| | This gene has been renamed with approval of the CGC (cyp-3->cyn-3) | Person_evidence | WBPerson466 |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
