WormBase Tree Display for Gene: WBGene00009221

WBGene00009221 SMap: S_parent: Sequence: F28F8
  Identity: Version: 2
    Name: CGC_name: acs-2 Person_evidence: WBPerson7030
            WBPerson2239
            WBPerson237
      Sequence_name: F28F8.2
      Molecular_name: F28F8.2
        F28F8.2.1
        CE09756
      Other_name: CELE_F28F8.2 Accession_evidence: NDB BX284605
      Public_name: acs-2
    DB_info: Database (10)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:50 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 23 Mar 2005 15:36:05 WBPerson2970 Name_change: CGC_name: acs-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acs
    Allele: WBVar01828574
      WBVar01828575
      WBVar01828576
      WBVar01828577
      WBVar01828578
      WBVar01828579
      WBVar00021620
      WBVar01463476
      WBVar01745450
      WBVar01463477
      WBVar01463478
      WBVar01463479
      WBVar01074595
      WBVar01463480
      WBVar01463481
      WBVar01074596
      WBVar01463482
      WBVar01074597
      WBVar01463483
      WBVar01074598
      WBVar01463484
      WBVar01074599
      WBVar01463485
      WBVar01074600
      WBVar01074601
      WBVar01074602
      WBVar01074603
      WBVar01074604
      WBVar01074605
      WBVar01074606
      WBVar01074607
      WBVar01074608
      WBVar01074609
      WBVar01074610
      WBVar01074611
      WBVar01074612
      WBVar01074613
      WBVar01074614
      WBVar01074615
      WBVar01074616
      WBVar00479323
      WBVar00479324
      WBVar00479325
      WBVar00256403
      WBVar00479326
      WBVar00479327
      WBVar01500160
      WBVar00591668
      WBVar01777182
      WBVar00591669
      WBVar02112622
      WBVar01500212
      WBVar01500213
      WBVar01499299
      WBVar00093603
      WBVar01828555
      WBVar02137735
      WBVar01828556
      WBVar01828557
      WBVar01499316
      WBVar01828558
      WBVar01828559
      WBVar01828560
      WBVar01828561
      WBVar01828562
      WBVar01828563
      WBVar01828564
      WBVar01828565
      WBVar01828566
      WBVar01828567
      WBVar01828568
      WBVar01828569
      WBVar01828570
      WBVar01828571
      WBVar01828572
      WBVar01828573
    Strain: WBStrain00032584
    Component_of_genotype: WBGenotype00000151
      WBGenotype00000152
      WBGenotype00000153
      WBGenotype00000154
    RNASeq_FPKM (74)
    GO_annotation (4)
    Ortholog (38)
    Paralog: WBGene00016849 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018269 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018579 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018488 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006351 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00007969 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00012356 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013440 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: acs-2 encodes an acyl-CoA synthetase; by homology, ACS-2 is predicted to catalyze conversion of a fatty acid to Acyl-CoA for subsequent beta oxidation; accordingly, loss of acs-2 activity via RNAi results in defects in fat metabolism; an ACS-2::GFP reporter fusion protein is widely expressed and appears to localize to mitochondria; acs-2 expression is positively regulated by the NHR-49 nuclear hormone receptor. Paper_evidence: WBPaper00005655
            WBPaper00025114
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Mar 2009 00:00:00
      Automated_description: Predicted to enable medium-chain fatty acid-CoA ligase activity. Involved in fatty acid metabolic process. Located in mitochondrion. Expressed in body wall musculature; hypodermis; intestine; neurons; and pharynx. Is an ortholog of human ACSF2 (acyl-CoA synthetase family member 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:3146 Homo sapiens Paper_evidence: WBPaper00039810
          Curator_confirmed: WBPerson324
          Date_last_updated: 31 Jul 2023 00:00:00
  Molecular_info: Corresponding_CDS: F28F8.2
    Corresponding_transcript: F28F8.2.1
    Other_sequence (21)
    Associated_feature: WBsf662130
      WBsf1002313
      WBsf1021034
      WBsf233036
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr3469
      Expr3780
      Expr1014898
      Expr1034024
      Expr1149753
      Expr2009213
      Expr2027450
    Drives_construct: WBCnstr00011406
      WBCnstr00011655
      WBCnstr00021644
    Construct_product: WBCnstr00011406
      WBCnstr00011655
    Microarray_results (25)
    Expression_cluster (473)
    Interaction (73)
  Map_info: Map: V Position: 8.35712 Error: 0.005311
    Positive: Positive_clone: F28F8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (52)
  Picture: WBPicture0000013098
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene