WormBase Tree Display for Gene: WBGene00003417

WBGene00003417 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: Y41C4A
  Identity: Version: 1
    Name: CGC_name: mrt-2 Person_evidence: WBPerson261
      Sequence_name: Y41C4A.14
      Molecular_name (4)
      Other_name: hpr-1
        CELE_Y41C4A.14 Accession_evidence: NDB BX284603
      Public_name: mrt-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mrt
    Allele: WBVar00092506 Inferred_automatically: From strain object: RB1208
      WBVar00144906
      WBVar00180402
      WBVar00180403
      WBVar01499701
      WBVar02036307
      WBVar00180404
      WBVar02118945
      WBVar00180405
      WBVar00180406
      WBVar00180407
      WBVar00180408
      WBVar00180409
      WBVar01335767
      WBVar00180410
      WBVar00180411
      WBVar00180412
      WBVar00180413
      WBVar00180414
      WBVar02067642
      WBVar02067643
      WBVar01846804
      WBVar00237279
      WBVar00410102
      WBVar00410103
      WBVar00410104
      WBVar02045789
      WBVar02095976
      WBVar02019355
      WBVar01401979
      WBVar01952905
      WBVar02114380
      WBVar02019356
      WBVar01952906
      WBVar02019357
      WBVar01952907
      WBVar02019358
      WBVar01629597
      WBVar01646736
      WBVar00101619
      WBVar01646737
      WBVar01270631
      WBVar01270633
      WBVar01646738
      WBVar01646739
      WBVar01646740
      WBVar01270642
      WBVar02057349
      WBVar02057350
      WBVar01270644
      WBVar01270645
      WBVar02057351
      WBVar01270647
      WBVar01270649
      WBVar01500138
      WBVar01500139
      WBVar02114782
      WBVar01919457
      WBVar01919459
      WBVar01499774
      WBVar01919460
      WBVar01607300
      WBVar01607301
      WBVar02030717
      WBVar01409798
      WBVar01409799
      WBVar01409801
      WBVar01409802
      WBVar02079458
      WBVar02088118
      WBVar01996032
      WBVar00864577
      WBVar01702320
      WBVar00864578
      WBVar00864579
      WBVar00864580
      WBVar00864581
      WBVar00864582
      WBVar00864583
      WBVar00864584
      WBVar01939892
      WBVar01939893
      WBVar00864585
      WBVar01939894
      WBVar00864586
      WBVar00864587
      WBVar01939895
      WBVar00144905
      WBVar01913356
      WBVar01723996
      WBVar01771301
      WBVar01723997
      WBVar01723998
      WBVar01771302
      WBVar01723999
      WBVar01771303
      WBVar01724000
      WBVar01827965
      WBVar01793458
      WBVar01793459
      WBVar01397740
      WBVar01397741
      WBVar01397742
      WBVar01990428
      WBVar01990429
      WBVar01397743
      WBVar01963503
      WBVar01963504
      WBVar01963505
      WBVar01548872
      WBVar02081748
      WBVar02071690
      WBVar01507998
      WBVar01507999
      WBVar01508000
      WBVar01567889
      WBVar01567890
      WBVar01567891
      WBVar01567892
      WBVar01567893
      WBVar01567894
      WBVar01567895
      WBVar01567896
      WBVar01579143
      WBVar01984171
      WBVar01579144
      WBVar01542379
      WBVar00180398
      WBVar00180399
      WBVar01542380
      WBVar00180400
      WBVar00180401
    Strain: WBStrain00031909
      WBStrain00004639
    RNASeq_FPKM (74)
    GO_annotation (26)
    Ortholog (34)
    Structured_description: Concise_description: mrt-2 encodes a highly conserved DNA-damage checkpoint protein homologous to the RAD1 protein found in S. pombe, Drosophila, and mammals; mrt-2 functions in the germline to maintain chromosomal integrity, and promote cell cycle arrest in mitotic germ cells and apoptosis in meiotic germ cells in response to genotoxic agents (DNA damage); mrt-2 mutations result in progressive telomere loss, chromosome fusion, and aneuploidy, eventually leading to germline mortality; MRT-2 interacts with HUS-1 and HPR-9, also conserved DNA-damage checkpoint proteins. Paper_evidence: WBPaper00003353
            WBPaper00003886
            WBPaper00003984
            WBPaper00005237
            WBPaper00005597
          Curator_confirmed: WBPerson1843
          Date_last_updated: 14 Jun 2011 00:00:00
      Automated_description: Predicted to enable 3'-5' exonuclease activity and damaged DNA binding activity. Involved in DNA damage response and telomere maintenance via telomerase. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Is an ortholog of human RAD1 (RAD1 checkpoint DNA exonuclease). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y41C4A.14
    Corresponding_transcript: Y41C4A.14.1
      Y41C4A.14.2
    Other_sequence: JI459899.1
      CBC00612_1
      CR07641
      HG06632
      EY472449.1
      GP01754
      OF00726
      GE638976.1
      HCC04778_1
      MA03330
    Associated_feature: WBsf994482
      WBsf225855
  Experimental_info: RNAi_result: WBRNAi00064153 Inferred_automatically: RNAi_primary
      WBRNAi00022481 Inferred_automatically: RNAi_primary
      WBRNAi00006768 Inferred_automatically: RNAi_primary
      WBRNAi00064152 Inferred_automatically: RNAi_primary
      WBRNAi00067556 Inferred_automatically: RNAi_primary
      WBRNAi00064105 Inferred_automatically: RNAi_primary
      WBRNAi00056356 Inferred_automatically: RNAi_primary
      WBRNAi00027845 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1016257
      Expr1031584
      Expr1159841
      Expr2013762
      Expr2031997
    Drives_construct: WBCnstr00005145
    Construct_product: WBCnstr00005145
    Microarray_results (20)
    Expression_cluster (108)
    Interaction (197)
    WBProcess: WBbiopr:00000014
      WBbiopr:00000091
  Map_info: Map: III Position: 12.0743 Error: 0.051368
    Positive: Positive_clone: Y41C4A Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4239
        4497
    Pseudo_map_position
  Reference (76)
  Picture: WBPicture0000013091
  Remark: Sequence connection from [Ahmed S, Hodgkin J]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene