WormBase Tree Display for Gene: WBGene00000528

WBGene00000528 SMap: S_parent: Sequence: T27D12
  Identity: Version: 1
    Name: CGC_name: clh-1
      Sequence_name: T27D12.2
      Molecular_name (21)
      Other_name: CELE_T27D12.2 Accession_evidence: NDB BX284602
      Public_name: clh-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: clh
    Allele: WBVar00241204 Inferred_automatically: From strain object: XA900
      WBVar00241205 Inferred_automatically: From strain object: XA901
      WBVar02157738
      WBVar02157739
      WBVar00250251
      WBVar01499702
      WBVar01547221
      WBVar01312537
      WBVar01547223
      WBVar01312540
      WBVar01312545
      WBVar01312549
      WBVar01312552
      WBVar00553391
      WBVar01312553
      WBVar01498613
      WBVar01891772
      WBVar01605168
      WBVar01935786
      WBVar01935787
      WBVar01605169
      WBVar00255070
      WBVar01498435
      WBVar01935788
      WBVar01935789
      WBVar01245621
      WBVar01784673
      WBVar01245623
      WBVar01784674
      WBVar01245625
      WBVar01245626
      WBVar01784675
      WBVar01784676
      WBVar01245630
      WBVar01784677
      WBVar01784678
      WBVar01245632
      WBVar01784679
      WBVar01245635
      WBVar01784680
      WBVar01245636
      WBVar01245637
      WBVar01784681
      WBVar01245639
      WBVar01784682
      WBVar00771728
      WBVar01784683
      WBVar01245641
      WBVar00771729
      WBVar01784684
      WBVar00771730
      WBVar01245643
      WBVar02033679
      WBVar00771731
      WBVar01245644
      WBVar00771732
      WBVar01245645
      WBVar00771733
      WBVar00771734
      WBVar00771735
      WBVar01982852
      WBVar00771736
      WBVar00771737
      WBVar00771738
      WBVar00771739
      WBVar02130797
      WBVar00771740
      WBVar00771741
      WBVar00771742
      WBVar00771743
      WBVar00771744
      WBVar00771745
      WBVar01499031
      WBVar00771746
      WBVar00771747
      WBVar00771748
      WBVar00771749
      WBVar00771750
      WBVar00771751
      WBVar00771752
      WBVar00771753
      WBVar00771754
      WBVar00771755
      WBVar02093992
      WBVar00771756
      WBVar00771757
      WBVar00771758
      WBVar00246501
      WBVar00771759
      WBVar00771760
      WBVar01792299
      WBVar00771761
      WBVar01478071
      WBVar00771762
      WBVar00771763
      WBVar00771764
      WBVar00771765
      WBVar01405781
      WBVar01405782
      WBVar00771766
      WBVar00771767
      WBVar00771768
      WBVar00771769
      WBVar00311013
      WBVar00771770
      WBVar00771771
      WBVar00311014
      WBVar00379257
      WBVar00771772
      WBVar00379258
      WBVar00771773
      WBVar02109835
      WBVar00379259
      WBVar00771774
      WBVar00379260
      WBVar00771775
      WBVar00379261
      WBVar00771776
      WBVar00379262
      WBVar01499431
      WBVar00379263
      WBVar00771777
      WBVar00771778
      WBVar01499432
      WBVar00379264
      WBVar00771779
      WBVar00379265
      WBVar00771780
      WBVar00379266
      WBVar00379267
      WBVar00771781
      WBVar00379268
      WBVar00771782
      WBVar00379269
      WBVar00771783
      WBVar00379270
      WBVar00771784
      WBVar00379271
      WBVar00771785
      WBVar00771786
      WBVar00379272
      WBVar00771787
      WBVar00379273
      WBVar00771788
      WBVar00379274
      WBVar00771789
      WBVar00379275
      WBVar00771790
      WBVar01377306
      WBVar00379276
      WBVar00771791
      WBVar00379277
      WBVar00379278
      WBVar00771792
      WBVar01377317
      WBVar00771793
      WBVar00379279
      WBVar00379280
      WBVar00771794
      WBVar00771795
      WBVar00379281
      WBVar00771796
      WBVar00379282
      WBVar00771797
      WBVar00379283
      WBVar00771798
      WBVar00379284
      WBVar00379285
      WBVar00771799
      WBVar00379286
      WBVar00277364
      WBVar00771800
      WBVar01538767
      WBVar00379287
      WBVar00771801
      WBVar01801952
      WBVar00771802
      WBVar00379288
      WBVar00229887
      WBVar00229889
      WBVar00379289
      WBVar00771803
      WBVar00379290
      WBVar00771804
      WBVar00229890
      WBVar00771805
      WBVar00771806
      WBVar00771807
      WBVar00771808
      WBVar01766481
      WBVar01943655
      WBVar01943656
      WBVar02018151
      WBVar01943657
      WBVar02029281
      WBVar00091942
      WBVar01989426
      WBVar00176246
      WBVar01498941
      WBVar00176247
      WBVar00255208
      WBVar00176248
      WBVar01256017
      WBVar00176249
      WBVar00255211
      WBVar00176250
      WBVar00255212
      WBVar00176251
      WBVar00176252
      WBVar00238709
      WBVar00176253
      WBVar00176254
      WBVar01256029
      WBVar00176255
      WBVar01440269
      WBVar00105999
      WBVar01256040
      WBVar00106000
      WBVar00106001
    Strain: WBStrain00031546
      WBStrain00040608
      WBStrain00040609
      WBStrain00051725
      WBStrain00051724
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (47)
    Paralog: WBGene00000530 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000531 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000529 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000532 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000533 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: clh-1 encodes two CLC-type chloride channels via alternative splicing, homologous to human CLC1 (OMIM:118425) and CLC2 (OMIM:600570); CLH-1a and CLH-1b are required for maintenance of normal body shape; null mutations of clh-1 cause abnormal alae and a wider body than normal, with the body phenotype being reversible by culture medium of high osmolarity. Paper_evidence: WBPaper00003816
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable voltage-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in plasma membrane. Expressed in several structures, including amphid sensillum; anterior hypodermis; cephalic sheath cell; spermatheca; and vulval cell. Human ortholog(s) of this gene implicated in Thomsen disease; idiopathic generalized epilepsy 11; and primary hyperaldosteronism. Is an ortholog of human CLCN1 (chloride voltage-gated channel 1) and CLCN2 (chloride voltage-gated channel 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:446 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2020)
      DOID:0081336 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2019)
      DOID:2106 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2019)
      DOID:0111312 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2020)
  Molecular_info: Corresponding_CDS (7)
    Corresponding_CDS_history: T27D12.2:wp49
    Corresponding_transcript: T27D12.2a.1
      T27D12.2b.1
      T27D12.2c.1
      T27D12.2d.1
      T27D12.2e.1
      T27D12.2f.1
      T27D12.2g.1
    Other_sequence (32)
    Associated_feature (12)
  Experimental_info: RNAi_result: WBRNAi00019329 Inferred_automatically: RNAi_primary
      WBRNAi00054307 Inferred_automatically: RNAi_primary
      WBRNAi00077546 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr978
      Expr1121
      Expr12665
      Expr15673
      Expr1013381
      Expr1030315
      Expr1157851
      Expr2010228
      Expr2028470
    Drives_construct: WBCnstr00010089
      WBCnstr00013831
      WBCnstr00037471
      WBCnstr00042471
    Construct_product: WBCnstr00037471
    Microarray_results (28)
    Expression_cluster (149)
    Interaction (15)
  Map_info: Map: II Position: 4.08004 Error: 0.003234
    Positive: Positive_clone: T27D12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4224
    Pseudo_map_position
  Reference (24)
  Remark: sequence connection from [George AL]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene