WormBase Tree Display for Gene: WBGene00015735

WBGene00015735 SMap: S_parent: Sequence: C13B9
  Identity: Version: 3
    Name: CGC_name: pdfr-1 Paper_evidence: WBPaper00031656
          Person_evidence: WBPerson3516
            WBPerson3480
      Sequence_name: C13B9.4
      Molecular_name (23)
      Other_name: seb-1 Person_evidence: WBPerson3006
            WBPerson1263
        CELE_C13B9.4 Accession_evidence: NDB BX284603
      Public_name: pdfr-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:56 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 18 Apr 2008 13:26:44 WBPerson2970 Name_change: CGC_name: pdfr-1
        3 29 Aug 2012 16:49:31 WBPerson2970 Name_change: Other_name: seb-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pdfr
    Allele: WBVar01429503
      WBVar01903829
      WBVar01903830
      WBVar01499890
      WBVar00243219
      WBVar01499891
      WBVar01903831
      WBVar01500260
      WBVar02151816
      WBVar02088054
      WBVar01990123
      WBVar01990124
      WBVar01990125
      WBVar01990126
      WBVar01990127
      WBVar00834686
      WBVar00834687
      WBVar01628623
      WBVar00834688
      WBVar01628624
      WBVar00834689
      WBVar00834690
      WBVar01628625
      WBVar00834691
      WBVar01628626
      WBVar01952290
      WBVar01628627
      WBVar00834692
      WBVar01264545
      WBVar01628628
      WBVar01952291
      WBVar00834693
      WBVar00278427
      WBVar01264546
      WBVar01628629
      WBVar01264547
      WBVar01952292
      WBVar00834694
      WBVar01264548
      WBVar01628630
      WBVar00834695
      WBVar00834696
      WBVar01264549
      WBVar01628631
      WBVar00834697
      WBVar01628632
      WBVar01264551
      WBVar00834698
      WBVar01628634
      WBVar00834699
      WBVar01264552
      WBVar01473946
      WBVar00834700
      WBVar00400194
      WBVar01264553
      WBVar00400195
      WBVar01264554
      WBVar00834701
      WBVar00834702
      WBVar00400196
      WBVar01264555
      WBVar00400197
      WBVar01396908
      WBVar00834703
      WBVar01264556
      WBVar01264557
      WBVar01396909
      WBVar00400198
      WBVar00834704
      WBVar01479885
      WBVar01264558
      WBVar00834705
      WBVar01396910
      WBVar00400199
      WBVar00834706
      WBVar00400200
      WBVar01264559
      WBVar01686776
      WBVar00834707
      WBVar01264560
      WBVar00400201
      WBVar01396912
      WBVar01330495
      WBVar00400202
      WBVar00834708
      WBVar01962833
      WBVar01264563
      WBVar00834709
      WBVar00400203
      WBVar00834710
      WBVar01264564
      WBVar00400204
      WBVar00834711
      WBVar01264565
      WBVar00400205
      WBVar00834712
      WBVar00400206
      WBVar01264566
      WBVar00400207
      WBVar01995420
      WBVar00834713
      WBVar01264567
      WBVar01264568
      WBVar00400208
      WBVar00834714
      WBVar01264569
      WBVar00400209
      WBVar00834715
      WBVar00400210
      WBVar00834716
      WBVar00834717
      WBVar00400211
      WBVar00834718
      WBVar00400212
      WBVar00400213
      WBVar00834719
      WBVar00400214
      WBVar01893528
      WBVar00834720
      WBVar00834721
      WBVar00400215
      WBVar00834722
      WBVar00400216
      WBVar00834723
      WBVar00400217
      WBVar00834724
      WBVar00400218
      WBVar01645195
      WBVar00400219
      WBVar00834725
      WBVar01645196
      WBVar00834726
      WBVar00400220
      WBVar00834727
      WBVar00400221
      WBVar00834728
      WBVar00400222
      WBVar00834729
      WBVar00400223
      WBVar01408753
      WBVar00834730
      WBVar01408754
      WBVar00834731
      WBVar00275833
      WBVar01490769
      WBVar00275834
      WBVar00834732
      WBVar01656915
      WBVar00834733
      WBVar00834734
      WBVar01656916
      WBVar00834735
      WBVar01656917
      WBVar00834736
      WBVar01656918
      WBVar00834737
      WBVar01656919
      WBVar00834738
      WBVar01656920
      WBVar01656921
      WBVar00834739
      WBVar01656922
      WBVar00834740
      WBVar00834741
      WBVar01656923
      WBVar00834742
      WBVar02150392
      WBVar00094437
      WBVar00834743
      WBVar00834744
      WBVar00834745
      WBVar00252930
      WBVar00834746
      WBVar00834747
      WBVar00834748
      WBVar00834749
      WBVar00834750
      WBVar00834751
      WBVar02053305
      WBVar00834752
      WBVar00834753
      WBVar00834754
      WBVar00834755
      WBVar00834756
      WBVar00834757
      WBVar00834758
      WBVar00834759
      WBVar00834760
      WBVar00834761
      WBVar00834762
      WBVar00834763
      WBVar00834764
      WBVar00834765
      WBVar00834766
      WBVar00834767
      WBVar00834768
      WBVar00834769
      WBVar00834770
      WBVar00834771
      WBVar00834772
      WBVar00834773
      WBVar01578903
      WBVar00834774
      WBVar00834775
      WBVar00834776
      WBVar02018891
      WBVar00834777
      WBVar01999681
      WBVar02069622
      WBVar00834778
      WBVar01999682
      WBVar00834779
      WBVar00834780
      WBVar01999683
      WBVar00834781
      WBVar00834782
      WBVar00062417
      WBVar00834783
      WBVar02103251
      WBVar00240281
      WBVar00834784
      WBVar00062422
      WBVar00834785
      WBVar00834786
      WBVar00834787
      WBVar00834788
      WBVar00834789
      WBVar00834790
      WBVar00834791
      WBVar00834792
      WBVar00834793
      WBVar00834794
      WBVar00834795
      WBVar00834796
      WBVar00099505
      WBVar02132194
      WBVar02132195
      WBVar02132196
      WBVar02132197
      WBVar01446220
      WBVar01446222
      WBVar01446224
      WBVar01446225
      WBVar02095922
      WBVar01837688
      WBVar01983914
    Strain (11)
    RNASeq_FPKM (74)
    GO_annotation (31)
    Ortholog (47)
    Paralog: WBGene00007664 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00014035 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002251 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00002252 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00009304 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00017947 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00017948 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: pdfr-1 encodes, by alternative splicing, three isoforms of a G-protein-coupled receptor (GPCR) required for normal locomotion; PDFR-1 is orthologous to Drosophila pigment dispersing factor (PDF) receptors, and to human CALCR (OMIM:114131, associated with susceptibility to osteoporesis); pdfr-1 is expressed in all body wall muscles and many head and tail neurons; the C. elegans neuropeptides PDF-1a, PDF-1b, or PDF-2 (orthologous to Drosophila PDF) activated PDFR-1 receptors with dose-dependent nanomolar potency; in vivo, excess PDF-2 induces a movement phenotype like that seen in a pdf-1 null mutant, indicating that PDF-1a/b and PDF-2 exert opposite effects on PDFR-1. Paper_evidence: WBPaper00012979
            WBPaper00028902
            WBPaper00031656
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 14 Jul 2008 00:00:00
      Automated_description: Enables calcitonin family receptor activity. Involved in several processes, including locomotory behavior; signal transduction; and sleep. Located in plasma membrane. Expressed in several structures, including I1 neuron; RMEV; ganglia; mechanosensory neurons; and vulD. Human ortholog(s) of this gene implicated in bone disease (multiple); hereditary lymphedema; and primary failure of tooth eruption. Is an ortholog of human CALCR (calcitonin receptor); CALCRL (calcitonin receptor like receptor); and PTH1R (parathyroid hormone 1 receptor). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080020 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9608)
      DOID:0050580 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:16709)
      DOID:0060387 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9608)
      DOID:2256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9608)
      DOID:0111341 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9608)
      DOID:11476 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1440)
      DOID:0111732 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9608)
  Molecular_info: Corresponding_CDS: C13B9.4a
      C13B9.4b
      C13B9.4c
      C13B9.4d
      C13B9.4e
    Corresponding_CDS_history: C13B9.4:wp127
    Corresponding_transcript (13)
    Other_sequence (25)
    Associated_feature (24)
  Experimental_info: RNAi_result: WBRNAi00010677 Inferred_automatically: RNAi_primary
      WBRNAi00005367 Inferred_automatically: RNAi_primary
      WBRNAi00027171 Inferred_automatically: RNAi_primary
      WBRNAi00040427 Inferred_automatically: RNAi_primary
      WBRNAi00024543 Inferred_automatically: RNAi_primary
      WBRNAi00024544 Inferred_automatically: RNAi_primary
      WBRNAi00028838 Inferred_automatically: RNAi_primary
    Expr_pattern (15)
    Drives_construct: WBCnstr00002179
      WBCnstr00002180
      WBCnstr00004248
      WBCnstr00004988
      WBCnstr00015834
      WBCnstr00015836
      WBCnstr00019100
      WBCnstr00021690
      WBCnstr00021702
      WBCnstr00028610
    Construct_product (12)
    Antibody: WBAntibody00001399
    Microarray_results (36)
    Expression_cluster (224)
    Interaction (12)
  Map_info: Map: III Position: -1.02511 Error: 0.00506
    Positive: Positive_clone: C13B9 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00010230
    WBPaper00012979
    WBPaper00018302
    WBPaper00019605
    WBPaper00028902
    WBPaper00031656
    WBPaper00034125
    WBPaper00035341
    WBPaper00038491
    WBPaper00039422
    WBPaper00041096
    WBPaper00041718
    WBPaper00042479
    WBPaper00043197
    WBPaper00043343
    WBPaper00043454
    WBPaper00044094
    WBPaper00047014
    WBPaper00047452
    WBPaper00047602
    WBPaper00047901
    WBPaper00051653
    WBPaper00054889
    WBPaper00055090
    WBPaper00055514
    WBPaper00057426
    WBPaper00061844
    WBPaper00062055
    WBPaper00062132
    WBPaper00062771
    WBPaper00063630
    WBPaper00063685
    WBPaper00063827
    WBPaper00063837
    WBPaper00063859
    WBPaper00065946
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene